Conserved Protein Domain Family
TIP_N

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pfam12457: TIP_N 
Tuftelin interacting protein N terminal
This domain family is found in eukaryotes, and is typically between 99 and 114 amino acids in length. The family is found in association with pfam08697, pfam01585. There are two completely conserved residues (G and F) that may be functionally important. TIP is involved in enamel assembly by interacting with one of the major proteins responsible for biomineralisation of enamel - tuftelin.
Statistics
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PSSM-Id: 403602
View PSSM: pfam12457
Aligned: 33 rows
Threshold Bit Score: 48.1388
Threshold Setting Gi: 748493938
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELK18625              18 ED-ERENFEI-TDWD-----LQNEFNPNRQR-HW----QTKEEATYGVWAErDSDE-------ERP-----SFGgkrism 73   black ...
CDP30322             132 DA-EDDEYLIpSTNP-----HDDEFADHNPRkRRrtgrEAKESAALGIFGS-ESEDegpsrkwKHK-----PLRn----- 194  Podosp...
Q2HBL6                28 DA-EEDEYLMpSRNP-----HESEFADFNPRkRRrtgrDSKESAALGIFGS-ESEDegsgrqwKHK-----SLRn----- 90   Chaeto...
jgi:MYCTH_2305956     30 D--EEDEYLMpSRNP-----HDSEFADLNPRkRRrtggDAKERAALGIFGS-ESEDegpggrwKHK-----RLRd----- 91   Thermo...
XP_007842841          24 DD-----FGLdEDPDareerALFENPYKRKRrKK----GGKEEALYGIFAE-SDDDdrslrrgGKT-----GKSk----- 83   Monili...
WGS:AACS:CC1G_00917   45 EDyDFDDFDT-NDPDmreerALFENPYKHKRrKK----NAKEDAIYGVFG--DDSEdegprnkRGG-----AKGk----- 107  Coprin...
XP_007400941          22 NDiGDSNYDT-NDPDaraerELFENPYGHKRrRG----DGKEDAIYGVFA--EDDEdkdyrmkRGG-----RTTk----- 84   Phaner...
EPT02977              22 DDyNDTNIHP-NDPDareerELFEDPYKRKRrRK----NGKEDAIYGVFA--DDDEdegfggrSGG-----KPEk----- 84   Fomito...
EMD39286              22 DDyNDPTIDE-NDPDaraerELFENPYKRKRrRK----DGKEDAIYGVFAD-DDDEdegfggkKGG-----RGQk----- 85   Gelato...
GAC99218              19 DDtTSDELNG-DDVDdavdaGVGQPSRKRMR-------RTKESAIYGIFG----EDeneeeggVGRsvrarDARgr---- 82   Pseudo...
ELK18625              74 elcgeakapvlaevveawaraRDYSAPVNFISAGLKKGAAEEael---edsDDEEKP 127  black flying fox
CDP30322             195 -------------------------kGVSFVSSSNVKPGPVDde-----ddDEDKED 221  Podospora anserina S mat+
Q2HBL6                91 -------------------------kGVSFVSSAKAKADSDDelde-eeaeYDDANP 121  Chaetomium globosum CBS 148.51
jgi:MYCTH_2305956     92 -------------------------kAVSFVSSAKADEDYDVel-----ddDDDDND 118  Thermothelomyces thermophilus...
XP_007842841          84 --------------------rSDWAKAPAFVSGN-KTAAAPDegm-----dvdSPAV 114  Moniliophthora roreri MCA 2997
WGS:AACS:CC1G_00917  108 --------------------rSDWTKAPAFVSSDKKVDL--DkamdvddvgDSSQDE 142  Coprinopsis cinerea okayama7#130
XP_007400941          85 -----------------------rKEAPAFTAGA-KVDL--DkdidvdvtmKEAEDS 115  Phanerochaete carnosa HHB-101...
EPT02977              85 --------------------rRDWAKAPAFVSGE-KVEL--DkvtdvdvemKDAVAE 118  Fomitopsis pinicola FP-58527 SS1
EMD39286              86 --------------------rSDWTKAPAFVSGE-KVNL--Dnni----eidEDEEM 115  Gelatoporia subvermispora B
GAC99218              83 --------------------kIDYRKGQAFVPASTSLPAATEeapselhirSDDSSG 119  Pseudozyma hubeiensis SY62
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