Conserved Protein Domain Family
Dynactin

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pfam12455: Dynactin 
Dynein associated protein
This domain family is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with pfam01302. There is a single completely conserved residue E that may be functionally important. Dynactin has been associated with Dynein, a kinesin protein which is involved in organelle transport, mitotic spindle assembly and chromosome segregation. Dynactin anchors Dynein to specific subcellular structures.
Statistics
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PSSM-Id: 403600
View PSSM: pfam12455
Aligned: 82 rows
Threshold Bit Score: 143.131
Threshold Setting Gi: 74635869
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESK85145      570 LQSELETLRTQTATAQSE-------SATASSQTAavlSMNLKLQSTAVKNQARMIEMECIKIESRERGELLGIIWPYLPQ 642  Moniliophthor...
NP_001255522  367 LNSQIQDQKDQVLSLEEQlhghisvDNDRASMVN-------QLQISANRNFAEDVERQVNAIEVEFARRQAGYLKAFLPD 439  Caenorhabditi...
EFX87445      530 MQESNYQLREALQRETNK---------PVGAPPE---VIDYQKMFTETKTFTKTIDLELRKLDVQQALQHVSYLCTYMPD 597  common water ...
EDX10387      226 LNDQLTDLRDRNSSNEKEsl----qDPSLKMVTE---TIDYKQMFAESKAYTRAIDVQLRQIELSQANEHVQMLTAFMPE 298  Drosophila si...
XP_001845217  566 LNDQCQELREKLNQESSK--------LVKDTISE---TIDFKQMFAESKAFTRAIDLQLRQIELTQANEHVKYLTAFMPE 634  southern hous...
EFA10255      518 LQEQSLQLQSRLETESSK---------PVSALPE---IVDFTKMFNETKAHTKAIDLELRRVEIQQLQSHIKFLTSYMPD 585  red flour beetle
EGI58700      716 LQEQCLQLQQRVQSTESTkt---nvRGADQQLAE---ILDFQKTFAETRAQTKAVDLELRRLDAEEARNHVCYLLSFMPP 789  Panamanian le...
XP_016659951  588 LREQNQDLQTQLMRESASk------DEVRSSIPE---MLDFKKMFAETKAHSRAIDLELRRMETQEAQQHIQYLLAYMPD 658  pea aphid
4_pfamImport    1 IQEENQELRSQLEISSKTs------SLSTSVIPE---MLDFKKMFAETKAHARAIELELRHMEVQQAQLHVQYLISFMPD 71  
XP_313086     540 lneQCQELRERLNQESSKqqq-qqqAKDTALITE---TIDFKQMFAESKAFTRAIDLQLRQIELTQANEHVRYLTAFMPD 615  Anopheles gam...
ESK85145      643 PYldT--DTDATNTYLYFSRMAAKAELINLVTAQAHSLPdsllaseeegGGKVSEVMVGICDMRTRLSSLSVLCRRFAAI 720  Moniliophthor...
NP_001255522  440 NFsrVggENDSILLVVMLPRLAAKTKLFASLAAQCFPQVpggmrrehvtKSHKGEQWAHVARVNYLANSINAALGKLESA 519  Caenorhabditi...
EFX87445      598 SFmaRggDYHSVQQLLLMSRLLFKCDMLAAQVKEKFPGsagdl--sntlKSPAADQCIFGARMLHWLFSLQGVVRQFSYA 675  common water ...
EDX10387      299 SFmtRggDHDSILVILLISRIVFKCDIVVSQTRERFPPVdaitr-eavtQGHAVQQYAFKCRLLHYVHSLQCALHQILYG 377  Drosophila si...
XP_001845217  635 IFmaRggDHDAVLVILLVSRIVFKAGIIVSQARERFSVVptidr-saivGGHEVYQFRFRSRLLHHVHNLQSIMHQFLYG 713  southern hous...
EFA10255      586 SFmnRggDYDAVLVLLLVLRMIQKTEILIGQIKDKFPGVdkidr-aailKGHAVEQFSFRCRASFYIYALQSILHQYYYA 664  red flour beetle
EGI58700      790 AFltRggDHDAILMLLLIPRMTQKTEILISQVREKYRSIekidr-tsvvRGHSVAQYSFRSRLCSHMYALQTTLGCFESA 868  Panamanian le...
XP_016659951  659 SFlsLggDYDAILSLLLLPRMIWKSEILMTHVRDKYPDVqeitk-etliKDHSAEQFATRSRLSFYLYSLQTALRQFVHG 737  pea aphid
4_pfamImport   72 TSntRrsDGDAIMLILLMPRMLAKCQVLISQLRDKFPPVatidk-tnttP---ALQFSTMSRFSAHIHTLQGILHQYVHS 147 
XP_313086     616 VFmaRggDHDAILVILLVSRIVFKSGIIVSQARERFSSVpqmdr-aailSGHEVAQFGFRSRLLHHVHNLQSIMHQFLFS 694  Anopheles gam...
ESK85145      721 LRYCDAERFLDVGKVYQEIAPLEKRVDMHIDLLRRDEFRAGECVADVAKIHAQFTHLSELYFAgfSY------DLGERQL 794  Moniliophthor...
NP_001255522  520 IGETTVEVLIKLTETYGEMSTHEKTVDQYLELLKKSRFDENTSLDSFVRPLVYFQNMFSLHIG--GDg----fNAAHWVS 593  Caenorhabditi...
EFX87445      676 LNSCSPQQFLEMGTLHQEMLQQEKAIDFYVELLRKDQLDENVQLDALEKVVNYFNSIYAVQFSsv-------vNGAALLT 748  common water ...
EDX10387      378 LNSCQPDTLLRAGSSLPEMVAQEKIVDGIIELLKSNQLDENSTTDNIEKCVAFFNAMNSVLLA--GEql---lNEIQMIR 452  Drosophila si...
XP_001845217  714 LTACTADTLLKIGASLPEMQAQEKMVDEIVDLLKANQLDENSSTDNLEKCVTFFNAMYLVLLA--GEdl---lNETQIVR 788  southern hous...
EFA10255      665 LNTCKTEALLKVGATYPEMASYEKIIDGFIELVKRDQLDENVPTEALEKCVGYFNTLFPVLLGp-ENr----lNHTQLLV 739  red flour beetle
EGI58700      869 LNSCNSEMLLKAGAAYPEMAAQEKSLDSLIELAKRDQLDENLPMDAIEKCCGYFATMFSVLFG--ESia---vNQARLIV 943  Panamanian le...
XP_016659951  738 MNTTTPETLIKIGESYPDMTIQEKVLNGYIEMLKIDQLDENVNTENLERCVAYFKHVYAPLIQdf------npHYEHLLL 811  pea aphid
4_pfamImport  148 LNTCKPETLLKVGASYVDMAQQEKALDQYIELLKREQVDENLNTESLEKIVGYFNTLHPQLLL---SsgdcsiHQGQLLA 224 
XP_313086     695 MTGCKADTLLKIGAALPEMLAQEKMVDEIVDLLKANQLDENSSTDNLEKCVTFFNAMYVVLLT--GEdl---vNETQIVR 769  Anopheles gam...
ESK85145      795 GYVASFDLDLDVFAASIGLARSSVKGIVneedtdvvldmggfdINTELLEPLQMLLNKGKSAKNVSRKLTKRL 867  Moniliophthora rorer...
NP_001255522  594 EICASLSAGLAYCRVNTQRISYFLQESI---------------TAGEVYNMLQTLNDEFAACESVILKAYRLL 651  Caenorhabditis elegans
EFX87445      749 DHGKVLLASCCGLTALGTRVQAMMQSGH---------------EGSDVAKSIKEVLSQANQWQQYARTIKRRL 806  common water flea
EDX10387      453 DCVASLGAACESILSDTAIAKVIIQEAG---------------ATSDSVLLLQFLNENMESVRQQVKLIKRRL 510  Drosophila simulans
XP_001845217  789 DCTASISAACDSITTDAAVIRTMIKGGD---------------ETSDSGLLLQYIVQNVEAVKQQLKLIKRRL 846  southern house mosquito
EFA10255      740 DNVKSLTSACDGFNNDSIVIRNLIETA----------------NVGDIGLLAQHVITTSEQLQQQLKLIKRRL 796  red flour beetle
EGI58700      944 NGTRTLGNTCDAIATDAAAIKVLIQG-----------------ESADIGKLCQHVETTCEVIQQHLKSARRRV 999  Panamanian leafcutte...
XP_016659951  812 DNVLVLSAACNTIQTDANIIKCVIQCD----------------GSSNVLKLCDDILVACEVIHQHLKQIKKRa 868  pea aphid
4_pfamImport  225 DLGKAVLCAIDSIQADANIILAHV-------------------QQGDGVSLLKKVQPWFEQLRTHLRQVRRRA 278 
XP_313086     770 DCTASIGAACDSIANDSNIIKILIKPGD---------------ETSDSGLLLQYILQNVENIRQQLKLVKRRL 827  Anopheles gambiae st...
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