Conserved Protein Domain Family
Milton

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pfam12448: Milton 
Kinesin associated protein
This domain family is found in eukaryotes, and is typically between 143 and 173 amino acids in length. The family is found in association with pfam04849. This family is a region of the protein milton. Milton recruits the heavy chain of kinesin to mitochondria to allow the motor movement function of kinesin.
Statistics
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PSSM-Id: 403594
View PSSM: pfam12448
Aligned: 12 rows
Threshold Bit Score: 126.613
Threshold Setting Gi: 167870877
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002018771         496 GN--------YMDSGNVSmTTLGAMSMSSSSGPRmasm------------------aypaG-SYYRG---GGNQSLGVKT 545  Drosop...
WGS:AANI:GJ18018-PA  471 GN--------YLDSGNVSmTQLGAMSMSSASGPRmasm------------------aypaG-SYYRGasgGSSNSLGLKT 523  Drosop...
EDS34260             421 RA--------NTTGFSDGySQLGSMTMSSSSQPRmapyvfpgatggtttthsyksgssiyS-TMY-------ESSLGGRS 484  southe...
XP_017213872         468 LRsqn--pspQLPG-----SSPTSLRSSRISTPR--------------------------T-SYNEPd--NISIIMEDKN 511  zebrafish
XP_025767584         411 QRsslapsplNIPGSNQT-SCFTSGRSSRVGTPR--------------------------SnSIYGSe-tGSGIILDNRT 462  Nile t...
CAF99478             461 RRsvtp-tssNIPGSNQSlSSRTSPQSSGLSSPH--------------------------S-SNYGGdvsGDGVALDNRV 512  spotte...
XP_014195076         521 QRsltp-tnsNIPGSNQSlSARTSPQSSGLSTPH--------------------------S-SIFGGdlsGESVALDNRT 572  Burton...
XP_021322520         387 QRsmgp-spmNIPGSNQT-SSMNSRRSSCMSTPR--------------------------S-SMYGGd----GVEIDNRT 433  zebrafish
CAF93056             254 aaeiegtfrkgldnpapsdyNPLSAHSSSSSTPR--------------------------T-SCYGSg--NTSITLEDKP 304  spotte...
XP_314926            320 RA--------NPNGFSDSfSQLGSMTMSSSSQPRmapg------------------ssvyS-TMYGG---GGGSSLGGRT 369  Anophe...
XP_015212332         386 QRsllp-spmNIPGSNQS-SA----LSSCRSTPR--------------------------S-SFYGSd--VSNIVIDNRT 430  spotte...
PNI81228             133 QRsltp-spmNIPGSNQS-SAMNSLLSSCVSTPR--------------------------S-SFYGSd--IGNVVLDNKT 181  chimpa...
XP_002018771         546 LSNESLNSQSDD--GY--PAQpSGVPGAPGARELEAALKRLTPG-----------EVLARRAMLSYApigtYNYDEPTmH 610  Drosop...
WGS:AANI:GJ18018-PA  524 LSSESLNSQSDD--GY--PAQpSGVPGAPGAKELEAALKRLTPA-----------EVLARRAMLSYApagtYNYDEPA-H 587  Drosop...
EDS34260             485 FSRESLVSESED--GYpgPAQ-AGIPGAPGAKDLEAALKRLTPA-----------EVLARRAMLQHApagtYSYDDQPs- 549  southe...
XP_017213872         512 SP----PTHSQDh-GLleSKR-LGQPGTPGGQDLEEALRSLSERqeshtserpffEVERERKLRALLsg-sSGSDGG--S 582  zebrafish
XP_025767584         463 SSIL---ETPDDg-SEdsNKRpPGTPGTPGSRDLEAALRRLSLRrdnylsekrffEEERERKLAYLA--------KEEeK 530  Nile t...
CAF99478             513 QSILME--SNQDsgTDgrEKK------ASGAEDLRLALRRLSLRrqnnlserrffEEERDRR-----------------Q 567  spotte...
XP_014195076         573 QSILMETASNQDs-TEgqEKK------ASGAEDLRLALRRLSLRrqnnlserrffEEERERR-----------------R 628  Burton...
XP_021322520         434 NSLLLETQSPQDg-SNdsNRK-PGTPGTPGSHDLQAALRRLSLRrdnylserrffEEERERKLNALAedksQFYEDSEdG 511  zebrafish
CAF93056             305 GC---SHAQKEDss---gPKR-LGQPGTPGGQDLEAALRSLSRRqqnhsserpffDVERERKLHALA----SKCDEAEcS 373  spotte...
XP_314926            370 YSRESLTADSED--GYpgPAQ-TGIPGAPGAKDLEAALKRLTPA-----------EVLARRAMLQHAplgtYSYDEQPa- 434  Anophe...
XP_015212332         431 NSIILETESPEGssDGdaNKK-PGTPGTPGSRDLEVALRRLSLRrenylserrffEEERERKLRDLA-------DGGElH 502  spotte...
PNI81228             182 NSIILETEAADLg-NDerSKK-PGTPGTPGSHDLETALRRLSLRrenylserrffEEEQERKLQELA-------EKGElR 252  chimpa...
XP_002018771         611 GGAgas------nsnLplgvrTP-DSI-----MSTGSSRmsassnnmSA--SMTHQwRLPEKLQIIKPMEGS 668  Drosophila per...
WGS:AANI:GJ18018-PA  588 GRSgvaaggqaagltLpmgvrTP-DSI-----MSTGSGS--------SG--LTTHQwRLPEKLQIVKPMEGS 643  Drosophila vir...
EDS34260             550 --------------gIplgcrTP-DSI-----MSTGSSGlsgm---------sstQwRLPEKLQIVKPIEGS 592  southern house...
XP_017213872         583 SGF------------L-----TPnSST-----ASTGTNYsgts-thsSGt-GSSRS-HLPERLQIVKPLEGS 629  zebrafish
XP_025767584         531 GGP------------G-----TPtESL-----FSLSSHTsvg--siwSGysFTPRS-YLPEKLQIVKPLEGS 577  Nile tilapia
CAF99478             568 GGHgalgvalehqsaM-----TPsESI-----MSLGNIHv-----------WASRGpYLPDKLQIVKPLEAp 618  spotted green ...
XP_014195076         629 GGHpglhdalsqeslL-----TPsESI-----MSLGNLHl-----------WASRGpYLPDKLQIVKPLEGS 679  Burton's mouth...
XP_021322520         512 GGP------------L-----TPaDSI-----MSLGLNSv------fSI--YSSRS-YLPEKLQIVKPLEGS 552  zebrafish
CAF93056             374 SGF------------L-----TPnDSLvsspaASTGTNYsngssrhsCGssGGSRS-YLPDRLQIVKPLEGS 427  spotted green ...
XP_314926            435 --------------gIplgcrTP-DSI-----MSTGSSGlsglssssA---AGNGQwRLPEKLQIVKPIEGS 483  Anopheles gamb...
XP_015212332         503 SGS------------L-----TPaESI-----MSLGTHHsg-----lSVfsFGSRS-YLPEKLQIVKPLEGS 546  spotted gar
PNI81228             253 SGS------------L-----TPtESI-----MSLGTHSrfseftgfSGmsFSSRS-YLPEKLQIVKPLEG- 300  chimpanzee
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