Conserved Protein Domain Family
MAGE_N

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pfam12440: MAGE_N 
Melanoma associated antigen family N terminal
This domain family is found in eukaryotes, and is typically between 82 and 96 amino acids in length. The family is found in association with pfam01454. This family is the N terminal of various melanoma associated antigens. These are tumor rejection antigens which are expressed on HLA-A1 of tumor cells and they are recognized by cytotoxic T lymphocytes (CTLs).
Statistics
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PSSM-Id: 403589
View PSSM: pfam12440
Aligned: 140 rows
Threshold Bit Score: 40.7217
Threshold Setting Gi: 586524563
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013841927   29 HMSEHCKPEEDPH-APTEAQGLEGVQDPMVEKGEatatTTPsltspsapspiTPLILGTPEEVPATGALGPLPsskIVCF 107 pig
XP_012920346    6 ksklRASEKRGRA-RAEAQGE-GAQATVAVEEES----TSSs---------pPQSEDITQSLPPAVSSSTFQGrrrAQAI 70  domestic ferret
26_pfamImport   1 -RNHRRRRERHRA-EREV-QGPAGAQGPSAQEEea--aASS-----------SAVVPGTPEEVPAGAIASPPQsppRASS 64 
XP_027810319    6 QKRQHHKDKGEPK-AQREAPSLNGVQVLRPEEEGa---SSAc---------iSSRSTPTLSKVPCPEPLICAQvpeRSSA 72  yellow-bellied...
XP_006161990    6 QESPQCTDDQHLQ-KHGEAQGSQVAQGSKAVEETsh-ySS------------HTLMPVNLSEAASAEAPSAPEgpqGFFT 71  Chinese tree s...
XP_023364680    7 EKSSQCTQDQHLH-TQSETQRLENAQVPKSMEEIfp-sFS------------SLLMPVRLNKAPAAKTLSTPEgpeSSFS 72  small-eared ga...
25_pfamImport   1 KMSPKCTPDEHLH-TQSETQGLESAQVPKPVEETlp-sSS------------LLPISGNLKEVPAAKVLSAPEgpqSFCS 66 
13_pfamImport   1 KKSPRCPPDQHLQ-TQSETQGLESAQVTKPVEEAlp-sSS------------LLPMSGNLKEAPAAKLLSAPEgpqSFCS 66 
XP_020935895   27 REIPHCTQEQH------CAQGLEAAQASKDPEEA----SLSs----------HSLMPGNQEGALAAGAPSTSQgpqSACV 86  pig
XP_002922854    5 QEIPSCTQEQ--HdAPSEIQGLEAAQVSKAVEETsp-sP-------------CPVMPGNMEEAVAAGTSSTAQspqSAYP 68  giant panda
XP_013841927  108 SPTAAPAMPRSQsAESSRREEEEG 131 pig
XP_012920346   71 TITSTANMCTRSdEDSNSQDEDRA 94  domestic ferret
26_pfamImport  65 SHTGLASPPGGDsNEGSSSQGAEG 88 
XP_027810319   73 LSVATAPTPGIPfIHLSSSQEAEG 96  yellow-bellied marmot
XP_006161990   72 SSIAIIATLWRRcDVGFSSEEEES 95  Chinese tree shrew
XP_023364680   73 TSIAITATSSSQpDESSRTEEEEK 96  small-eared galago
25_pfamImport  67 SPGDITATSSNKpDEGTRSKEEKK 90 
13_pfamImport  67 SSGDNTAMSSSKsDEDARSEEEKK 90 
XP_020935895   87 AYAVTTALLSGKlGEHSSSQEKEG 110 pig
XP_002922854   69 SYAVLTAVSPSKsDEGSSSQEKED 92  giant panda
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