5C6D


Conserved Protein Domain Family
USP7_ICP0_bdg

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pfam12436: USP7_ICP0_bdg 
ICP0-binding domain of Ubiquitin-specific protease 7
This domain is one of two C-terminal domains on the much longer ubiquitin-specific proteases. This particular one is found to interact with the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110.
Statistics
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PSSM-Id: 403586
View PSSM: pfam12436
Aligned: 106 rows
Threshold Bit Score: 179.647
Threshold Setting Gi: 301105899
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5C6D_A         61 IRLWPMQARSNGTKRPAMLDNEA-DGnkTMIELSDnEN---PWTIFLETVdpelaasgatlpkfdkDHDVMLFLKMYDPK 136 
EDV28289      560 MRPWPLFHRPNGTTRVIGLD-EA-DYdrTLFDLAD--Nd-eNWFIFLETLlpdsglk--slppydkNSQVIVFLKYYDVM 632  Trichoplax ad...
XP_001948017  625 IRIWPLIASKHESLRPMYLDGEA-NAlkTIQDLHD--SsstTWNIWLELVepgvss----lmpfdrSNQSLIFFKLFIPE 697  pea aphid
ETN64231      639 FRLWEVKKPSNL--KPHRFEYIEpVAteTCAKYAS-PEtkhSCTIFLELPapggpgv--lepaklsFDDTLLFFKFYDPV 713  Anopheles dar...
XP_001861802  617 MRMWTVSK---NGLRIHKFQLIDaNTneTCSKYGY-QDpknSWTIFLEMAspetnq-----lkpieQNDLLIFFKSYDPA 687  southern hous...
1_pfamImport    1 IRIWPSYPHRTQGQKFVYFDVNE-DIhkQLINVES------PWFVFVELLrpdcpgi---iqpfdrKRDLFLFFKFYDPI 70  
EDV95916      568 MRLWGMCSIAAKDQKFMYIDVEA-YAmrTLNEIPN--DvqkPWCIFLELAqadcpgr---lppfnpQLDVLLFLKFYDAR 641  Drosophila gr...
EFX71348      627 FRIWPMAGRTNNTMRPKALDWES-DLgkCVTDVAD--Nc-nPWTCFLELLppdsgls--alppfqqDRMVLLFFKYYDPT 700  common water ...
XP_004225844  625 FRLWLFSQRPNNSWRPTLLETGE-TVgkHLIEVAE--Ne-nPWHLWLETIqpdsted--tlpafdkQGDILVFLKMYTPS 698  vase tunicate
EDO34745      602 IRPWPLQQRSNGTTRPAVFDMES-DIdkPIGQLVDa----sSWVIFLETVdpengta--plpsydkKGDVLLFFKYYDPA 674  starlet sea a...
5C6D_A        137 TRSLNYCGHIYTPi-sCKIRD--LLPVMCDRAGFIQDTSLILYEEV---KPNlTERIQDYDVSLDK-------AldELMD 203 
EDV28289      633 NRKTSYVGHLYIEl-sMSLDD--IAKKCREFVSIPSSVPLLFFEEV---KPNrVDILTDTSIPLLKv-----mG--DFTD 699  Trichoplax ad...
XP_001948017  698 ERLLVYCGYHFASf-eTPLDS--LINIMNKRAGFEEDTKLAIYKET---NKNeIEKITKLDDPICEi-----iQ--TSTY 764  pea aphid
ETN64231      714 DKRLNYCGHGLYKp-sMTVAE--LVRDLNRRAHFEPDTELQVYEVV---DINkAQKISDQQQTLQQa-----lS--LLGH 780  Anopheles dar...
XP_001861802  688 EKRLNYCGHGFFKt-fRFLSDeyFQEECRKRAHYEPDTEIRLYEVTdinKAVkMQEFFVIDSAL---------S--LPIN 755  southern hous...
1_pfamImport   71 KKCLTYLDHGQYQl-sTRVRD--IIPHINKTLGFDENTELSVYEEC---PSNtVQKITNLNDTLEKvlsqlsrD--NSVQ 142 
EDV95916      642 RQHLNYIGCTQQPl-nRRLCE--LVPEINRKLGFASNTKLTVFDEY---A---GWKIHDLEEPIGNlln--maP--KQLQ 708  Drosophila gr...
EFX71348      701 TRQIHYAGHHYALi-kRPLAD--LVPILLQRAGLPPHTQLELYEEV---KPGmIDTIEHIDKPLETi-----lE--ELMD 767  common water ...
XP_004225844  699 TRTISYCGHVSVPiegTSVVA--MEKTLRKRGGLPPNTPLLLFEEI---SASeLRPIHDRNLQFGEv-----mD--KLMD 766  vase tunicate
EDO34745      675 QRVLALVGHLYVPl-vTKFSE--LMPYLCEKAGLPQGTPLFMFEEV---KINyAEQIRDTSLTIEHg-----vE--ELMD 741  starlet sea a...
5C6D_A        204 GDIIVFQKDDPEn----------------------DnselpTAKEYFRDLYHRVDVIFCdkTIPN-DpGFVVTLSNRMNY 260 
EDV28289      700 GDILCFQIDSKDek-------------------------ipTVEDYFRELFNRIDVKFFdkNVSNd-pGFTLTLSQRMHY 753  Trichoplax ad...
XP_001948017  765 GEILIYQKEELVkt-------------------------ypSVTDHFKNICSQVYITFCdkLIPNd-pGFTLGLPMWMLY 818  pea aphid
ETN64231      781 GTIVVFEKRHPPg----------------------DnlefpTCEAYFKDLFCRMEVVFLdtLIPNd-tGFTLDLSSESTY 837  Anopheles dar...
XP_001861802  756 GSIIIIEKVSAGe---------------------vEsyefpTCEEYLKDLYCRIEVLFVdtLNPNd-sGFTLDLSSESNY 813  southern hous...
1_pfamImport  143 GFILIFEKRIATnldsvdgfignqqntvvhpqynsLklelpTVDHYFRDLMHRIEILFIdkTIPNd-pGFTLELSNRAPC 221 
EDV95916      709 GTILIFERENVD-----------------------AkldlpTVADYLMDVVSRIEISFSdkANPYe-pDFTLELSPRCNY 764  Drosophila gr...
EFX71348      768 GDIICYQKYDPEv----------------------MgsqlgTVKKYFYDLLHRIEVTFCdkTNPLdVtGFTLSMSEDLGY 825  common water ...
XP_004225844  767 GNIIVFQPVEPSc---------------------------pDAARYFLDVFFRVDVILCdkNDPLd-pGFTVSLNRNWTY 818  vase tunicate
EDO34745      742 GDIICYQRSDNEl---------------------lEtselpTVIEYFRDLHHRVEVLFCnkNQPDd-pGFTVVLSQRMNY 799  starlet sea a...
5C6D_A        261 FQvAKTVAQRLNTDPMLLQFFKSqG-YRDGPG-NPLRHnyegtlrdlL 306 
EDV28289      754 IEiANAVASHLSIDPMMLQFFKSyQpYRDAAShHPIRCsfegtlmdlf 801  Trichoplax adhaerens
XP_001948017  819 HDmLQAVAERVSVDQRKLQIYFSvNgQKECPG-EPIKNsyngpirdli 865  pea aphid
ETN64231      838 DQiAKAVGRRINVNPYEIQFFKS-KnYSDLPG-QPLSHsfggslrdvL 883  Anopheles darlingi
XP_001861802  814 EQiAKACGRRINVDPYEIQFFKC-KnFSEIPG-QPLPHnysgtlkdiL 859  southern house mosquito
1_pfamImport  222 TAmAQAVAEKINTDINRILFFKC-LgYKDTPG-SSVRPlhensikdlL 267 
EDV95916      765 DQlAQTVAVHLNTDPTKLQFFKCiSyDWKMPG-VDVPYtytgtindlw 811  Drosophila grimshawi
EFX71348      826 DQvARLVGDRIGYPPNMLQFFKS-QgYREGPG-PSIRYhwetslkemV 871  common water flea
XP_004225844  819 GQfAEKVAERLDTDPMMLQFFRV-QnVRDQPG-NVIRSsfdgqlkdlL 864  vase tunicate
EDO34745      800 TQvAKAVATHLEVDPMKLQFFKG-QiYRDAPG-NALRCtfegtlrdlL 845  starlet sea anemone
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