Conserved Protein Domain Family
Condensin2nSMC
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pfam12422: Condensin2nSMC (This model is not part of the current CDD release)
Condensin II non structural maintenance of chromosomes subunit
This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolyzis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.
Links
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Statistics
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PSSM-Id: 520259
Aligned: 37 rows
Threshold Bit Score: 151.561
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002431793   74 KVVESTAFVESEHGQKFIAWSLL-LSsklMLDIHKTIMLEL--SLCNKKKAGWYGKIYVIAWHNAVDD----VKSAL--- 143 
EFP05554       66 MMFFSPALTICPEGVKLVAEVFVkIG---ISNGLTLLEKNItkFDITDAECQRYGEVFKTAWLDAYQDasfdLTEEI--- 139 
EGT38869       58 MMYCSPALMACKEGIKLLALILDkIG---VRNGLTLLEKQIlkSDLTDTDCQRYGDVFATTWLNAHSDanfdLTEEL--- 131 
Q20818         58 CIFFAPALLICPEGIKLSAEILPkIG---VGNGLILLEKLIlkFNLTDTECQRYGEVFVTAWRNAYQEanfdLTEEL--- 131  Caenorhabditi...
XP_045097749   58 MMFFSTALTACPEGVKLVAAILFkIG---VANGMTLVEKNMtkYDMTDAECQRYGQVFTTAWLDAFQEgefdLAEEM--- 131 
Q5CVQ5         42 SCLYSSTIVKNVEGQNFISRVISkLSidiHNELVNIIKSFV--PKLSSSLLICYGNILFILWLDYSNQs---NEERMqnl 116  Cryptosporidi...
XP_002139716   56 NCLNSITIIKNSDGQDLISYMIVqLGskmIDKLFACIDEIL--PKSNNSVISGLSNILYSIWKNSNMNs---TKEYT--- 127 
XP_001327152   58 DTIHCPNYYKTEKAKKFVASIVH-VVffkLPEICERFKSIL--RNEKTEQAEQFGELCVTVWSKCDVT----ERSTF--- 127 
7_pfamImport    1 ECVTSLTYLNTREGRLHIASVLS-KDvtlVKPIQEIIRQYL--PELTKNQAAYYGEVYFNAWNMAKPN----VQKEI--- 70  
XP_002178944  328 RMAASPQSLRSPEGRRFLAYLFY-VDeslQKDLHRAFRAQI--PDARASVIEAYSEIYWRAWKEAPDVv---IQESI--- 398 

XP_002431793  144 EKSCLQHLMEAFFKEHrtslelSKCGKNILTVLDVLHSErkKKNPEFVTMITEAYQPILWKYLQSGFNMHRCNAADIFYK 223 
EFP05554      140 ETDVIRIICQYALYGQ------KPFAAKFRKVLSAFVSGk-KKDVNFAEMITRILNGCLYRAMDATNYIVSSSAVELFFM 212 
EGT38869      132 ETDVYHVFFQHALFGQ------KPLCAKFQKVLSAFAAQr-KENPDFAIMISGMLNGCIYRALDSKNSAVQTSGMEVFFM 204 
Q20818        132 ETDVISVMCQHALYAH------RPTCTKFQNVIAAFAHAk-KLDKSVDEMVTRLLNGCLYRALDAPNYIVQSSAAEVFFN 204  Caenorhabditi...
XP_045097749  132 ENDIIRVICQNALYAQ------KPLGSKFRKMLVPFATSk-KQEVSVDEMISRILEGCLWRALESSNYIVQSAASEVFFM 204 
Q5CVQ5        117 EEAIQRTFCIGSIKLN------PLIALRMRLILHGFHSN--RDDFRVNKLLLRLYDPLIWRYISVANWKVRLNTTALLAI 188  Cryptosporidi...
XP_002139716  128 EELIQKKLCNGCIRLN------PFMASKIRLLLSSFHEN--RYESDVNDLLVRLYDPILWRYLSVANWKVRLNSTALFAI 199 
XP_001327152  128 QVQLLKPIAECAILAEt-----PQFSKNCRAFLEKFGVKr-SRRKELWTALTHIYEPIVFRYLHAANPLVRDNSLSLFTS 201 
7_pfamImport   71 EECCIQDLMERVFTLNrhglemGKIGVRVLMILSSLHSS--RRLHKFSDKITELYAPLIWRYLRSDHPLVRCNAAQVFLD 148 
XP_002178944  399 ESNVLSDLIYAVLHIAn-----PNMATSLMTLLEPFHDA--KKNADVETLLHRMYGPILWRSLSSANALVRVHATTILAE 471 

XP_002431793  224 -AFPLQR 229 
EFP05554      213 -FFPLIS 218 
EGT38869      205 -FFPFVE 210 
Q20818        205 -FYPLIG 210  Caenorhabditis elegans
XP_045097749  205 -FFPLTG 210 
Q5CVQ5        189 -LFPLID 194  Cryptosporidium parvum
XP_002139716  200 -LFPLID 205 
XP_001327152  202 cAFPIES 208 
7_pfamImport  149 -VFPLEK 154 
XP_002178944  472 -VFPLQE 477
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