Conserved Protein Domain Family
Condensin2nSMC

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pfam12422: Condensin2nSMC 
Condensin II non structural maintenance of chromosomes subunit
This domain family is found in eukaryotes, and is approximately 150 amino acids in length. This family is part of a non-SMC subunit of condensin II which is involved in maintenance of the structural integrity of chromosomes. Condensin II is made up of SMC (structural maintenance of chromosomes) and non-SMC subunits. The non-SMC subunits bind to the catalytic ends of the SMC subunit dimer. The condensin holocomplex is able to introduce superhelical tension into DNA in an ATP hydrolysis- dependent manner, resulting in the formation of positive supercoils in the presence of topoisomerase I and of positive knots in the presence of topoisomerase II.
Statistics
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PSSM-Id: 403578
View PSSM: pfam12422
Aligned: 41 rows
Threshold Bit Score: 148.092
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002431793   74 KVVESTAFVESEHGQKFIAWSLL-LSSKLMLDIHKTIMLEL--SLCNKKKAGWYGKIYVIAWHNAVDD----VKSAL--- 143  human body louse
EGT38869       58 MMYCSPALMACKEGIKLLALILDkIG---VRNGLTLLEKQIlkSDLTDTDCQRYGDVFATTWLNAHSDanfdLTEEL--- 131  Caenorhabditi...
EFP05554       66 MMFFSPALTICPEGVKLVAEVFVkIG---ISNGLTLLEKNItkFDITDAECQRYGEVFKTAWLDAYQDasfdLTEEI--- 139  Caenorhabditi...
CAP39597       58 MMFFSTALTACPEGVKLVAAILFkIG---VANGMTLVEKNMtkYDMTDAECQRYGQVFTTAWLDAFQEgefdLAEEM--- 131  Caenorhabditi...
Q20818         58 CIFFAPALLICPEGIKLSAEILPkIG---VGNGLILLEKLIlkFNLTDTECQRYGEVFVTAWRNAYQEanfdLTEEL--- 131  Caenorhabditi...
Q5CVQ5         42 SCLYSSTIVKNVEGQNFISRVISkLSIDIHNELVNIIKSFV--PKLSSSLLICYGNILFILWLDYSNQs---NEERMqnl 116  Cryptosporidi...
XP_002139716   56 NCLNSITIIKNSDGQDLISYMIVqLGSKMIDKLFACIDEIL--PKSNNSVISGLSNILYSIWKNSNMNs---TKEYT--- 127  Cryptosporidi...
XP_016659232   88 KC---PLFLETETGKLAIADIFT-CSQQLFLKFHQTVRQNI--PKANRSEAEAYGEIYFMAWINSNST----IREVI--- 154  pea aphid
3_pfamImport    1 ECVTSLTYLNTREGRLHIASVLS-KDVTLVKPIQEIIRQYL--PELTKNQAAYYGEVYFNAWNMAKPN----VQKEI--- 70  
KOB63799       97 YTLNLPKFYETSDGKIFLSHVWS-QNESIAYHLFNKFVHNT--AVLAHNHICHYSEIIYSTWRNCEED-----MKEI--- 165  Plasmodium fa...
XP_002431793  144 EKScLQHLMEAFFKEHRtslelSKCGKNILTVLDVLHSErkKKNPEFVTMITEAYQPILWKYLQ---------------S 208  human body louse
EGT38869      132 ETDvYHVFFQHALFGQ------KPLCAKFQKVLSAFAAQr-KENPDFAIMISGMLNGCIYRALD---------------S 189  Caenorhabditi...
EFP05554      140 ETDvIRIICQYALYGQ------KPFAAKFRKVLSAFVSGk-KKDVNFAEMITRILNGCLYRAMD---------------A 197  Caenorhabditi...
CAP39597      132 ENDiIRVICQNALYAQ------KPLGSKFRKMLVPFATSk-KQEVSVDEMISRILEGCLWRALE---------------S 189  Caenorhabditi...
Q20818        132 ETDvISVMCQHALYAH------RPTCTKFQNVIAAFAHAk-KLDKSVDEMVTRLLNGCLYRALD---------------A 189  Caenorhabditi...
Q5CVQ5        117 EEAiQRTFCIGSIKLN------PLIALRMRLILHGFHSN--RDDFRVNKLLLRLYDPLIWRYIS---------------V 173  Cryptosporidi...
XP_002139716  128 EELiQKKLCNGCIRLN------PFMASKIRLLLSSFHEN--RYESDVNDLLVRLYDPILWRYLS---------------V 184  Cryptosporidi...
XP_016659232  155 EEQmF-DFISKTLTLRRtgl-afYAYRNALILLQSMQNH--RKHLMFSKVITKLYAPVIWRQLT---------------S 215  pea aphid
3_pfamImport   71 EECcIQDLMERVFTLNRhglemGKIGVRVLMILSSLHSS--RRLHKFSDKITELYAPLIWRYLR---------------S 133 
KOB63799      166 LYTqIEYLVNFSLKCP------IKIAARFRDVLSIFHTN--KGDKDINRLIFKIYDPVIWRSLMrghnnlckrgypsiiC 237  Plasmodium fa...
XP_002431793  209 GFNMHRCNAADIFYKAFPLQ 228  human body louse
EGT38869      190 KNSAVQTSGMEVFFMFFPFv 209  Caenorhabditis brenneri
EFP05554      198 TNYIVSSSAVELFFMFFPLI 217  Caenorhabditis remanei
CAP39597      190 SNYIVQSAASEVFFMFFPLT 209  Caenorhabditis briggsae
Q20818        190 PNYIVQSSAAEVFFNFYPLI 209  Caenorhabditis elegans
Q5CVQ5        174 ANWKVRLNTTALLAILFPLI 193  Cryptosporidium parvum
XP_002139716  185 ANWKVRLNSTALFAILFPLI 204  Cryptosporidium muris RN66
XP_016659232  216 EFSVVRCNATDILARAYPLE 235  pea aphid
3_pfamImport  134 DHPLVRCNAAQVFLDVFPLE 153 
KOB63799      238 PNWKIRFNATCIFQLIYPVV 257  Plasmodium falciparum HB3
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