Conserved Protein Domain Family
Fox-1_C
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pfam12414: Fox-1_C (This model is not part of the current CDD release)
Calcitonin gene-related peptide regulator C terminal
This domain family is found in eukaryotes, and is typically between 69 and 99 amino acids in length. The family is found in association with pfam00076. This family is the C terminal of Fox-1, a protein involved in the regulation of calcitonin gene-related peptide to mediate the neuron-specific splicing pattern. Fox-1, with Fox-2, functions to repress exon 4 inclusion.
Links
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Statistics
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PSSM-Id: 520254
Aligned: 7 rows
Threshold Bit Score: 73.4191
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008111765 239 VASIPYPMMAp-----AALA-YRGA-LRGRGRAtIYNPIRAAPAPSPVPAYGS--------------------------- 284
5_pfamImport   1 LTGFPYPTAG------AAVA-YRGAhLRGRGRA-VYNTFRAAPPPPPIPTYGA--------------------------- 45 
2_pfamImport   1 LPGFPYPSAAaaa-atTAAA-FRGAhLRGRGRP-VYSAVRAAVPQPAIPTYPG--------------------------- 50 
Q642J5       228 VPGFPYPAATa-----AAAA-YRGAhLRGRGRT-VYNTFRAAAPPPHIPAYGG--------------------------- 273 zebrafish
NP_001402839 258 MPGFPYPAAT------AAAA-YRGAhLRGRGRT-VYNTFRAAAPPPPIPAYGG--------------------------- 302 human
XP_007482984 169 VTGFPYPTTG------TAVA-YRGAhLRGRGRA-VYNTFRAAPPPPPIPTYGAaleqtlvkmpvpwaglapcplppqqtp 240 gray short-tail...
XP_021332503 252 VPGFPYPTTAaaaaaaSTAAsFRGAhLRGRGRP-VYGAVRAAVPQPAIPAYPG--------------------------- 303 zebrafish

XP_008111765 285 --------------------VLYPDGL-YG-SD-IY-GYpAAYRVAQTPAAAaa-----taAAAYSDGYGRVYtTAEPY 334
5_pfamImport  46 --------------------ILYLDNIaYK-NN-IAgGY-AAYRYAQPAAAA---------ATAYSDSYGRVYtAADPY 92 
2_pfamImport  51 --------------------VVYQDGF-YG-AAdLYwGW-ALYRYAQPTAVTgat----aaAAAYSDSYGRVY-TTDPY 101
Q642J5       274 --------------------VVYQDGF-YG-AD-IYgGY-TAYRYTQPATAT---------AAAYSDSYGRVY-AADPY 318 zebrafish
NP_001402839 303 --------------------VVYQDGF-YG-AD-IYgGY-AAYRYAQPTPAT---------AAAYSDRNQFVFvAADEI 348 human
XP_007482984 241 epayptspafpplscpfasrVVYQDGF-YG-AE-IYgGY-AAYRYAQP---Aa-------aAAAYSDSYGRVYaAADPY 305 gray short-taile...
XP_021332503 304 --------------------VVYQDGF-YGaTE-LYsGY-TAYRYTQPTAVAsptaaaaaaAAAYSDSYGRVYaadpya 359 zebrafish
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