2LC0


Conserved Protein Domain Family
FhaA_N
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pfam12401: FhaA_N (This model is not part of the current CDD release)
FhaA, N-terminal domain
This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide- specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates of Ser/Thr protein kinases (STPK) and plays a role in the regulation of cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis.
Links
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Statistics
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PSSM-Id: 520246
Aligned: 87 rows
Threshold Bit Score: 84.8825
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2LC0_A          8 VQRVERKLEQTVGDAFARIFGGSIVPQEVEALLRREAADGIQSLQGNRLL-APNEYIITLGVHDFEKLGAD-PELKSTGF 85  Mycobacterium ...
WP_012257858    4 LRRFEQFMEQMVEGSVARIFRSTIQPVEIARRLEKAMESN-QTISVKRVI-VPSSYRAFLNPQDFAIFQPV-RQQIEQEL 80  Chloroflexus
jgi:Sthe_1695   4 LQRFENFFERLMEGSVGRIFRTPVQPAEIGRRLERAMEGN-QLATVDGIV-VPNDYVVFLNPEDMVQFADI-VPSLCRQM 80 
WP_015263116    4 iARFEEVAENLFTGMFKKNNNAKLQPVELAKELVRTMHKN-KQVSISQVY-VPNVYRVFLHSSDWSPFASF-GDAFLVEL 80  Desulfitobacte...
10_pfamImport   1 LNKVESIAEQMATFLFSKSV-GTIQPVQVARELNKIMLKN-KQVSISHVY-VPNVYTVSLNPEDYAVLESF-GETLLVEL 76 
WP_013625492    4 LNKFETAAEYLFTNMFKKTS-SSIQPVEVAGKLLKAMLRN-KQVSISHVY-VPNIYRVQLNKEDYKIMENF-GETFLLEL 79  Syntrophobotul...
WP_012797621   10 LINL---LTRPFAWLFRLLHKRGAQPVDIVRAMVRAGKSQARGWGGDCKRqAPNLYRVAISQADWEAFYGLnPKGIQQRA 86  Slackia heliot...
WP_012799799    4 FSKFEGKMEDTFEGTANKISNAPISPVQIVKKAEKQMRRERVVSAGKEY--APTLYTVLVNADDDQRLFGF-YPTLAGET 80  Slackia heliot...
4_pfamImport    1 LSRFEGRMEDTFEGAADKMFDAPISPVQIAKKAEKQMRREKMVGAGKQY--APTLYTVLVNPDDDRRLMGY-YPTLAGET 77 
WP_013252593    4 LRTFESRVSDAF-GGAPQGYTAPFSFRKLAKKAARELEAETYEIDGIDT--APALYTILVSSADDVAMRPL-YAQLTQEI 79  Olsenella uli

2LC0_A         86 ARDLADYIQEQGWQTYGDVVVRFEQSSNLHTGQFRAR 122 Mycobacterium tuberculosis H37Rv
WP_012257858   81 ATYLSELAAERNFTMLDHPRVVITEDPAVPRRSIQVE 117 Chloroflexus
jgi:Sthe_1695  81 EDWLIDLAEERNYGFIDQVRVQMIGDENVPRRRISVE 117
WP_015263116   81 SKYLHAEGKKSSFTFLSKPSIELHCDDTVKPHEMFIe 117 Desulfitobacterium dichloroeliminans
10_pfamImport  77 AKHLYDEGTRQGYTFLALPVVRMQPSEKIDAGLMKT- 112
WP_013625492   80 AQHLYTEAGKQGYTFLTLPLVELYANQKIGRGEIEIE 116 Syntrophobotulus glycolicus
WP_012797621   87 GDMLNRRLAEADLVLDGFATVVLYQDLSLDLGEFRVY 123 Slackia heliotrinireducens
WP_012799799   81 ETRLAATASDEGLFMDGQPLVRFIVDENLKHGKFDVi 117 Slackia heliotrinireducens
4_pfamImport   78 ETYLTAKASEQGLVMDGQPLVRFIVDEDLKHGKFDI- 113
WP_013252593   80 TAFVEAQAQSRSYVFVGKPLARFMVDPSLRSGKFAVF 116 Olsenella uli
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