Conserved Protein Domain Family
Peptidase_C70
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pfam12385: Peptidase_C70 
Papain-like cysteine protease AvrRpt2
This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defence responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.
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Statistics
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PSSM-Id: 403550
Aligned: 10 rows
Threshold Bit Score: 116.405
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
UANL:O3I_014820   57 VFGAQTLPYLQQt------------qTAAQWCWAADGSSIATYLH--KPISQSRYCAL-------VRGadtagscpdqQA 115 
CBW74344         182 QYAFFDVKYHHQ--------------QHVNMCGDASAAMLLSFFGk-KPVDLNRNPRR-------IWE----------GL 229 
EIC31518           2 PSIQLNVPLEAQ--------------EKANCCWHTSAYMIWLYWQq-NGKGAGPMNTVask--yeVADt--------tGL 56  
CDB19889         227 ARENSEIPYFLQwderwgyetygsdfLAVTGCGPTCLSMITCGLTgsETWNPLTVAQFsekegyyVPGegtswslmteG- 305 
jgi:Aave_0201     88 GGSKLVVPYIPQ--------------NGTRGCWEATMNMLRAYFGq-PPLDKGQLAYLyda--egVPK----------EL 140 
CCE23625          21 KHHGRDDP---------------------TGCWYASLCMVGFYFEagPRLGNPELFKRp------LDKlkhgtdvghfPI 73  
CBL45771         283 LSNTLDVCYNVElv----------pqQTGMSCWAAGFAMIVGWRDr-VSINPEEIARA-------SGHwaq----yqsGL 340 
Q2SFG4           294 MNQSFDVRYNVQlv----------pqQTGFSCWAAGFAMIVGWREq-MSIDPSEIARA-------VGYwsq----yqnGL 351  Hahella ch...
WP_013534541     993 SVHWTDVPMNYQ--------------SSPMSCWAAAASMVAGWRDq-ASIPDSEIAAK-------VPVfda----fnrGL 1046 Pseudoxant...
WP_013262253      65 TSIRYDIPGEFQvl----------aqPSSMACWATVFTMLKSWRSq-RGMTIEQATAS-------VGQrwldlyradtGL 126  gamma prot...

UANL:O3I_014820  116 SLEEIAAAFRKIGFga-aVGAPLS---------------MTKVVDEISANRPILTGIAWTAG---GGHAQVIYGFDADAg 176 
CBW74344         230 NSTQLINLLESHGFrvssIPLPPRferhpkdrtvtggweSSQLCSLLNGFGPIICGGRWPRHv--FGHCILLIGATENT- 306 
EIC31518          57 YPTEFITLAEKVGL----YKLPVKnq-----------hsENDLFKYLRDGGPVWCAGYWFG----VGHIIVLTGVGKGK- 116 
CDB19889         306 --------ASNLGLtaenIPVTQ-----------------ENILAALRSGIPLICSM-YPGDftyTGHFIVLTGIDENGa 359 
jgi:Aave_0201    141 NGPLDYATRNRKAKlk-nIPVPAGks-----------wdADKIRALLDQHGPLEARIESPNDe-lVAHAIVLTGIDEDGd 207 
CCE23625          74 GGDAELKMMQNEGLe--eVPEPADkk-----------wkNWQLAKMLKEYGPLMMSWWAPG-----AHVSVVIGIDSEAn 135 
CBL45771         341 N-PEDVSVMQVWGF----VPEPPQsy------------mISAFANLLRRYGPLWVASAEPG-----PHIRVITGIRGDGt 398 
Q2SFG4           352 H-PEDLRVMNVWGF----TAEAPQsy------------tIEAFVNLLRNYGPLWIATAEPG-----PHIRVVTGIHGDGt 409  Hahella ch...
WP_013534541    1047 YGHERGYLADAWNL----YAEPPAsy------------tVDAWRQMLEAKGPLYIAQISAAGa-sSGHVRVLVGMDSDGa 1109 Pseudoxant...
WP_013262253     127 SGDDKVNFISTAGL----VAEPPQsy------------sIQGWETLLRNYGPIWVTTDEAPGkawAIHARIITGIYGDGt 190  gamma prot...

UANL:O3I_014820  177 ------tITYGDPWPSSRRSVtqALDSYTQNAD 203 
CBW74344         307 -------VVYHDPWSGAKRTK--TLQQFNGFLD 330 
EIC31518         117 -------AYFNDPDQGVKKEG--TVKWFNEKLA 140 
CDB19889         360 -------ITVNDPNSPANTKKhwSMTEILPQIR 385 
jgi:Aave_0201    208 -------VICHDPELGPGQKV--SIAMLNAAFD 231 
CCE23625         136 ------eVIYHDPENAPNSRM--SLNNFNSKLM 160 
CBL45771         399 pd--gttLYINDPWEQ-------GMTSFQPSNR 422 
Q2SFG4           410 pd--gtiLHINDPWEQ-------GMSSFRPSNR 433  Hahella chejuensis KCTC 2396
WP_013534541    1110 pdgsgttMYLHDPALGPIRQ---SFAEFVALYE 1139 Pseudoxanthomonas suwonensis
WP_013262253     191 pe--gtcFKIVDPAGGRRYEE--SIAVFIPKYE 219  gamma proteobacterium HdN1
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