Conserved Protein Domain Family
Peptidase_C70

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pfam12385: Peptidase_C70 
Papain-like cysteine protease AvrRpt2
This is a family of cysteine proteases, found in actinobacteria, protobacteria and firmicutes. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis. AvrRpt2 from Pseudomonas syringae pv. tomato DC3000 triggers resistance to P. syringae-2-dependent defense responses, including hypersensitive cell death, by cleaving the Arabidopsis RIN4 protein which is monitored by the cognate resistance protein RPS2.
Statistics
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PSSM-Id: 403550
View PSSM: pfam12385
Aligned: 10 rows
Threshold Bit Score: 116.405
Threshold Setting Gi: 524368651
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
UANL:O3I_014820   57 VFGAQTLPYLQQt------------qTAAQWCWAADGSSIATYLH--KPISQSRYCAL-------VRGadtagscpdqQA 115  Nocardia b...
CBW74344         182 QYAFFDVKYHHQ--------------QHVNMCGDASAAMLLSFFGk-KPVDLNRNPRR-------IWE----------GL 229  Paraburkho...
EIC31518           2 PSIQLNVPLEAQ--------------EKANCCWHTSAYMIWLYWQq-NGKGAGPMNTVask--yeVADt--------tGL 56   Methylomic...
CDB19889         227 ARENSEIPYFLQwderwgyetygsdfLAVTGCGPTCLSMITCGLTgsETWNPLTVAQFsekegyyVPGegtswslmteG- 305  Blautia sp...
WP_011793391      88 GGSKLVVPYIPQ--------------NGTRGCWEATMNMLRAYFGq-PPLDKGQLAYLyda--egVPK----------EL 140  Acidovorax...
CCE23625          21 KHHGRDDP---------------------TGCWYASLCMVGFYFEagPRLGNPELFKRp------LDKlkhgtdvghfPI 73   Methylomic...
CBL45771         283 LSNTLDVCYNVElv----------pqQTGMSCWAAGFAMIVGWRDr-VSINPEEIARA-------SGHwaq----yqsGL 340  gamma prot...
Q2SFG4           294 MNQSFDVRYNVQlv----------pqQTGFSCWAAGFAMIVGWREq-MSIDPSEIARA-------VGYwsq----yqnGL 351  Hahella ch...
WP_013534541     993 SVHWTDVPMNYQ--------------SSPMSCWAAAASMVAGWRDq-ASIPDSEIAAK-------VPVfda----fnrGL 1046 Pseudoxant...
WP_013262253      65 TSIRYDIPGEFQvl----------aqPSSMACWATVFTMLKSWRSq-RGMTIEQATAS-------VGQrwldlyradtGL 126  gamma prot...
UANL:O3I_014820  116 SLEEIAAAFRKIGFga-aVGAPLS---------------MTKVVDEISANRPILTGIAWTAG---GGHAQVIYGFDADAg 176  Nocardia b...
CBW74344         230 NSTQLINLLESHGFrvssIPLPPRferhpkdrtvtggweSSQLCSLLNGFGPIICGGRWPRHv--FGHCILLIGATENT- 306  Paraburkho...
EIC31518          57 YPTEFITLAEKVGL----YKLPVKnq-----------hsENDLFKYLRDGGPVWCAGYWFG----VGHIIVLTGVGKGK- 116  Methylomic...
CDB19889         306 --------ASNLGLtaenIPVTQ-----------------ENILAALRSGIPLICSM-YPGDftyTGHFIVLTGIDENGa 359  Blautia sp...
WP_011793391     141 NGPLDYATRNRKAKlk-nIPVPAGks-----------wdADKIRALLDQHGPLEARIESPNDe-lVAHAIVLTGIDEDGd 207  Acidovorax...
CCE23625          74 GGDAELKMMQNEGLe--eVPEPADkk-----------wkNWQLAKMLKEYGPLMMSWWAPG-----AHVSVVIGIDSEAn 135  Methylomic...
CBL45771         341 N-PEDVSVMQVWGF----VPEPPQsy------------mISAFANLLRRYGPLWVASAEPG-----PHIRVITGIRGDGt 398  gamma prot...
Q2SFG4           352 H-PEDLRVMNVWGF----TAEAPQsy------------tIEAFVNLLRNYGPLWIATAEPG-----PHIRVVTGIHGDGt 409  Hahella ch...
WP_013534541    1047 YGHERGYLADAWNL----YAEPPAsy------------tVDAWRQMLEAKGPLYIAQISAAGa-sSGHVRVLVGMDSDGa 1109 Pseudoxant...
WP_013262253     127 SGDDKVNFISTAGL----VAEPPQsy------------sIQGWETLLRNYGPIWVTTDEAPGkawAIHARIITGIYGDGt 190  gamma prot...
UANL:O3I_014820  177 ------tITYGDPWPSSRRSVtqALDSYTQNAD 203  Nocardia brasiliensis ATCC 700358
CBW74344         307 -------VVYHDPWSGAKRTK--TLQQFNGFLD 330  Paraburkholderia rhizoxinica HKI 454
EIC31518         117 -------AYFNDPDQGVKKEG--TVKWFNEKLA 140  Methylomicrobium album BG8
CDB19889         360 -------ITVNDPNSPANTKKhwSMTEILPQIR 385  Blautia sp. CAG:52
WP_011793391     208 -------VICHDPELGPGQKV--SIAMLNAAFD 231  Acidovorax citrulli
CCE23625         136 ------eVIYHDPENAPNSRM--SLNNFNSKLM 160  Methylomicrobium alcaliphilum 20Z
CBL45771         399 pd--gttLYINDPWEQ-------GMTSFQPSNR 422  gamma proteobacterium HdN1
Q2SFG4           410 pd--gtiLHINDPWEQ-------GMSSFRPSNR 433  Hahella chejuensis KCTC 2396
WP_013534541    1110 pdgsgttMYLHDPALGPIRQ---SFAEFVALYE 1139 Pseudoxanthomonas suwonensis
WP_013262253     191 pe--gtcFKIVDPAGGRRYEE--SIAVFIPKYE 219  gamma proteobacterium HdN1
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