Conserved Protein Domain Family
P1_N

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pfam12378: P1_N 
Mycoplasma adhesin P1, N-terminal
This entry represents the N-terminal domain cytadhesin P1 from Mycoplasma. Cytadhesins are virulence factor proteins which mediate attachment of bacterial cells to host cells for invasion. P1 forms a transmembrane complex with P40/P90 called the 'Nap', which mediates motility and infectivity. Structure of P1, revealed that it consists of a large N-terminal domain consisting of seven consecutive beta-sheets each with four antiparallel beta-strands, except for the seventh which has two strands, and adopts a beta-propeller topology. Those two strands correspond to the cytoadherence epitope which has important immune properties. The N-terminal domain is highly variable and described as a structured core surrounded by a fuzzy surface.
Statistics
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PSSM-Id: 463556
Aligned: 8 rows
Threshold Bit Score: 283.618
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P11311     73 NTSFSSLPLTgeNPGAWALVrdnsakgitagsgs---qqttydptrteaalTASTTFALRRYDLAGRALYDLDFSKLnpq 149  Mycoplasmoides pn...
P20796     72 NNNFSSLKITgeNPGSFGLVrsqndnlnissvtknssddnlkylnavekylDGQQNFAIRRYDNNGRALYDINLAKMenp 151  Mycoplasmoides ge...
CDN40531   66 PSRFSHLLVA--DGGYIVLD-------------------------------NHKNTAGISRLDSFGNVLWQHAEAPI--- 109 
Q7NBJ6     79 NNNFNGLKLA--NGGYIFIS--------------------------------KDNDNMIYRTDLFYNTLWTYRFANN--- 121  Mycoplasma gallis...
Q9REM8     61 NSNFTSLSIDgtNPGALVLT----------------------------------GSKSISRIDLYGNVIWTFDPGNT--- 103  Mycoplasmoides ga...
Q7NBT1     71 NANFSSSPTK--DGGLLVIT----------------------------------TDGRLERIDSFGYLKWELNLRNIna- 113  Mycoplasma gallis...
CDN40266   68 NNNFQGIQLN--DGGLAVLTg------------------------------NVNDGYAVTRTNAFGGVEWSFNPEGV--- 112 
CDN40264   68 NTSFSGITVNglNPGAAVLT----------------------------------EPNAVSRTDFFGNVLWTFAPNSLtnt 113 
P11311    150 -tptRDQTGQITFNPFGGFGLSGAAPQQWN--EVKNKVPVEVAQDPSNPYRFAVLLVPRSVVYYEQLqrglglpqqrtes 226  Mycoplasmoides pn...
P20796    152 stvqRGLNGEPIFDPFKGFGLTGNAPTDWN--EIKGKVPVEVVQSPHSPNLYFVLLVPKVALEYHNLnnqvvkeslevka 229  Mycoplasmoides ge...
CDN40531  110 --------------------------------ERHDRAIVEVLQNPIDPSIYYLLSIPKEISKQ---------------- 141 
Q7NBJ6    122 --------------------------------NQISRHVVEVAYDTYDPTTFYVLTVPRNNDDNAIR------------- 156  Mycoplasma gallis...
Q9REM8    104 ----NDLTGKVGFYDANNRLTAFSGDVPFNvsDLSSKTVVEATQDQEDPNVFYLLLIPDAAVQQEQKtkdqvfenyfmsd 179  Mycoplasmoides ga...
Q7NBT1    114 ---lATVDEEQNLVYSDNRIVTKPLDAVFIn-NVSKKVVAEAIQSQEDPTIYYLLAVSDQILTNDLKdq----------- 178  Mycoplasma gallis...
CDN40266  113 ----------------TGSFASKNIENKFKnqAIKEKAVIEIRQDAILPNTFYALLVPKDAIPDpatgl----------- 165 
CDN40264  114 -katKISSDATLIRMPNGDLVTDAIDFDQ---DIRNKTVVEVRQDASLSNIFYLLLIPTNFAEITP-------------- 175 
P11311    227 gqntsttgamfglkvknaeadtaksneklqgaeatgssttsgsgqstqrggssgdtkvkalkievkkksdsedngqlqle 306  Mycoplasmoides pn...
P20796    230 tqssfnptqrlqkdspvkdsskqgeklsettassmssgmats-----------------------------------tra 274  Mycoplasmoides ge...
CDN40531      --------------------------------------------------------------------------------     
Q7NBJ6        --------------------------------------------------------------------------------      Mycoplasma gallis...
Q9REM8    180 apatgdtsaegsatpagggssssaagggavapaaasstar--------------------------------------lv 221  Mycoplasmoides ga...
Q7NBT1        --------------------------------------------------------------------------------      Mycoplasma gallis...
CDN40266      --------------------------------------------------------------------------------     
CDN40264      --------------------------------------------------------------------------------     
P11311    307 kndlanapikrseesgqsvqlkaddfgtalsssgsggnsnpgsptpwrpwlATEQIHKDlPKWSASILILYDAPYARN-- 384  Mycoplasmoides pn...
P20796    275 kalkvevergsqsdsllkndfakkplkhknssgevkleaekefteawkpllTTDQIARE-KGMGATVVSFYDAPYSEN-- 351  Mycoplasmoides ge...
CDN40531  142 ---------------------------------------------------NIHKFDENlWLLATITIIKENLKSSPSt- 169 
Q7NBJ6    157 ---------------------------------------------------AYANGSKD--GFGVITKIKENLDRELDk- 182  Mycoplasma gallis...
Q9REM8    222 eegnsagmgtmtptastsetvidynsdqnkipkpktlldssessesinggrTYANINTQnNLQGVIVKVNENLFNSEN-- 299  Mycoplasmoides ga...
Q7NBT1    179 -------------------------------------------------llSFQQLATDlTSQGVVLKVKENPTQISD-- 207  Mycoplasma gallis...
CDN40266  166 ----------------------------------------------vssthTYDEINEQvKLQASVVQLTQTVDKSQTaf 199 
CDN40264  176 ---------------------------------------------------SVSEIEADsSKQATVVVLSEDLSTNSNv- 203 
P11311    385 RTAIDRVDHLDPKAMTANYPPSWRTPKWNHHglwdwkar-------------------------dvllqttGFFNPRRHP 439  Mycoplasmoides pn...
P20796    352 HTAFGLVDHIDPKKMVENYPPSWKTPKWNHHgiwdynar-------------------------nlllqttGFFNPRRHP 406  Mycoplasmoides ge...
CDN40531  170 AVNLVGTFFVNPIAMIQNLPQSWKK---------------------------------------------------TGDT 198 
Q7NBJ6    183 RADLQSEIAIDPQALLNNIPSTWNS-----------------------------------------------------NP 209  Mycoplasma gallis...
Q9REM8    300 PFAVENMAFIKPKDMVDNYPSTWTQGSANGKmtnvlqfykhdnpnavnnrfyrakyypkrletqtttplidSSFSPYEHP 379  Mycoplasmoides ga...
Q7NBT1    208 PVGIIDYAMISPTDLTQNYPASWKTNTLSLYgd-------------------------------------nGSFRKADHP 250  Mycoplasma gallis...
CDN40266  200 TYIINNVVSIPPRAMVNNYPLQWKVDSNGGP----------------------------------------DFFSPNYHK 239 
CDN40264  204 KYGIVAVSNIKPSDMTKNYPSQWKSMM--------------------------------------------TSFTKTNHP 239 
P11311    440 EWFDGGQTVADNektgfdvdnsentkqgfqkeadsdksAPIALPFEAYFANIGNLTWFGQALLVFGGNGHVTKSAHT--A 517  Mycoplasmoides pn...
P20796    407 EWFDEGQAKADNtspgfkvgdtd----hkkdgfkknssSPIALPFEAYFANIGNMVAIGNSVFIFGGNGHATKMFTT--N 480  Mycoplasmoides ge...
CDN40531  199 SFLKGASDLLHN--------------------------GSFSYSYFTYLANIGNMVFKNNTIYLFGNAGv--------nE 244 
Q7NBJ6    210 SFLSNTIGFTNN--------------------------GKFIFSYNNYLANLANLIVYKQNIYLIGGNGNINPTISD--R 261  Mycoplasma gallis...
Q9REM8    380 EWYED---------------------------------NQFVMPWMQYITNLGGLYAKDGMVYLFGGNGTWVNNESA--- 423  Mycoplasmoides ga...
Q7NBT1    251 SWFNNd-------------------------------sNFISLPWLQYITNLANLYEYKDNVFLFGGNGNWVNDDQSvrQ 299  Mycoplasma gallis...
CDN40266  240 GWYEN---------------------------------NKFVLPWAMYITNMGNLYGINGTVLMFGGNGTVFENKQA--- 283 
CDN40264  240 SYFDNeg------------------------------gEAISLPWKIYLTTVGNLYADNGQIAMAGGNGTMFSGQVDdeE 289 
P11311    518 ----PLSIGVFRVRY----NATGTSATVT-----GWPYALLFSGMVN---------KQTDGLKD------LPFNNNRWFE 569  Mycoplasmoides pn...
P20796    481 ----PLSIGVFRIKY----TDNFSKSSVT-----GWPYAVLFGGLIN---------PQTNGLKD------LPLGTNRWFE 532  Mycoplasmoides ge...
CDN40531  245 ----GLSLGVYSLNL--------TNFVIK-----AWPYAKLIAGWSA---------NPKENYl------nFPIHQDPNFQ 292 
Q7NBJ6    262 ----FQSLGIFRIDK--------NLNQVT-----GWPYAVLIGGWSQ---------TRDSNFGv-----nLPIFQDAQFT 310  Mycoplasma gallis...
Q9REM8    424 -----LSIGVFRTKFenrtAEAPGNTKTV-----GYPYGILLSAISF---------DATRNgla---lapASLGQDVGYH 481  Mycoplasmoides ga...
Q7NBT1    300 qatkYLSIGVFRIRFy---KDLSTRPTVT-----GYPYAYLLSSLTS---------NDPDTq-------kLLLGQNTNYT 355  Mycoplasma gallis...
CDN40266  284 -----LSIGMFRLNFglpsANNSGQVEIT-----GIPYAYILAGIQA----------NSFNPITdfeftnAPIGQNKNFK 343 
CDN40264  290 ----ILSMGMFRINFdfdqISQSNSPQLRrvsadGFPYATLLSGLAApivgsllpdNSKKSYIIgselfnLPIGQDDTFA 365 
P11311    570 YVPRMAVAG 578  Mycoplasmoides pneumoniae M129
P20796    533 YVPRMAVSG 541  Mycoplasmoides genitalium G37
CDN40531  293 YIFRGSIAG 301 
Q7NBJ6    311 YVIRGAIAG 319  Mycoplasma gallisepticum
Q9REM8    482 FVPRLAVGG 490  Mycoplasmoides gallisepticum str. R(low)
Q7NBT1    356 LVPRIAVGG 364  Mycoplasma gallisepticum
CDN40266  344 YVPRMAVGG 352 
CDN40264  366 YVPRIAVSG 374 
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