Conserved Protein Domain Family
Casc1

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pfam12366: Casc1 
Cancer susceptibility candidate 1
This domain family is found in eukaryotes, and is typically between 216 and 263 amino acids in length. Casc1 has many SNPs associated with cancer susceptibility.
Statistics
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PSSM-Id: 372076
View PSSM: pfam12366
Aligned: 19 rows
Threshold Bit Score: 161.842
Threshold Setting Gi: 74871436
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002012193  271 QVQIPLSVLCDNLTLRCVHTLFDHLSEEAKSYEQVIDGVvninggi-mdiddclVNEWLMQLNLVD--KIISALEQRLTE 347  Drosophila mo...
XP_002068326  913 WTTKYIQRTELDRDNLIVTVRTDRVGLFGFAFKRYAHFP---------------FRHWCMEPSEENanEIVFTLDTFHVR 977  Drosophila wi...
Q9VWZ4        854 WSTRDVHDTKFNEDKLSIQFRTGRLGIFGFALNKYSNMP---------------YQTWDLRPDMKNpgTIIFSFTASLIS 918  fruit fly
XP_001983474  257 RVQIPLSVLCDNLTLRCVHSFFDHVSESAKSFGQQMDMCpnalnggmmdiedclINEWLMQVDIMD--KMINKLELKIME 334  Drosophila gr...
XP_001983475  244 EVQMPLSVLHDCLTLRCIHTKFDNHSQYAKSFDPIIPDSpvqanggivdiedclINEWLMQLDIQQ--ELLASMMAKREN 321  Drosophila gr...
XP_001870057  188 ELAKPVSFDLRDALMRGLWTGYDHLSDLEPTFRCGCLEPvpdl-------lasqEIEWADRQNLRV--KRLTEMREARAG 258  southern hous...
XP_001956983  249 EVQVPISVLDDCLTIRCVHTSFDHYSQNAHSAPDYVVDNdympsagikdmeeslISEWLLQQDIQS--EVLDAMNQRYQD 326  Drosophila an...
EDW44295      253 TIQLPLSVLCDNLTLRCVRTFFDPLSHLAKSFELVIDSSvipncgl-vdiadsvMSEWMAQMDIQE--DLMVKMESEMRA 329  Drosophila se...
XP_017864476  541 WTTRYIKHTEFLPESCTVKIQTDRLGVFGFAFKSYEHFP---------------FKGWSLQYNKDNinEIIFTLDTYHVR 605  Drosophila ar...
XP_001983474  891 WTTKYIKRTEYDPQSFTFKIQTDRLGIFGFACKRYEHFP---------------FRHWQLQYNEENsdEIIFTLDTHHVR 955  Drosophila gr...
XP_002012193  348 YEQYTAevaqkeaaarLVEKRANKSRSPKDAKSKRSEQRLSKRILREPEMIPEGMFPDPLQRFIEQEQQEFDDFLNQFln 427  Drosophila mo...
XP_002068326  978 VVLYIS----------NKGIRGYVTDLTKEYTAKPVKYMTIEEPIFDFGDFRKRFQEKNVNIFAEHDAKFYIENGYYS-- 1045 Drosophila wi...
Q9VWZ4        919 LDMTITksg-----ytVNNFQGGSTQ---GITDMIGKTLSLSE-------LKATLILSAVDIFPDEDAFCYTEG--SC-- 979  fruit fly
XP_001983474  335 YKKFMSqm------svKVAPPKWGEIDQKKRKSDKSSKSKNVKKPKEPQNLPDGMFPDPYDAFLEQEQQEFDEFLDKFmn 408  Drosophila gr...
XP_001983475  322 YEDIMRtiaek-tekmNKE--------KKANEGKSTK-TVIPKAPKEPPLVPPGMFPDAYATFLEREQQQYLDTLDEIyn 391  Drosophila gr...
XP_001870057  259 FEAAQRqke----leeAEMAKS-----------------------------SDETTVDIDGDFVQQEMQLYLQKMEQIg- 304  southern hous...
XP_001956983  327 YQDTLNlia----ertEQAAKA----DKSDADGRKSK-IIIPKIPKLVNPVPPGMLPDIYQEFIHREEKQYKSFLDVAyd 397  Drosophila an...
EDW44295      330 YNEAISfi---------------aeAEAKEKRKPQKKKVAIPKPPKMPQELPAGMFPDPRKIFLEHEKRDCTDFFNRYfh 394  Drosophila se...
XP_017864476  606 VVLFIT----------NAGIRGYATKIIEEYVANPIKYLEIKEPTSDFTELRRRFCENNINIFAAHDACYYIEKGYFS-- 673  Drosophila ar...
XP_001983474  956 IVLFIT----------NAGIRGYVTKLTDEYVAKPVKYVEIEQPISDYRELRRRFCEKNVNIFAENDALFYIENGYFS-- 1023 Drosophila gr...
XP_002012193  428 PQNLKLa-pDEINLRQYNILGGLYSMHFVRKPMHKe---fEKFNITLhedgri-lytqqDVRadv-----gsRRSTRLKS 497  Drosophila mo...
XP_002068326 1046 LKMLAL---ELHVYDAMAIHCKMIKFFRSEWNRLA-----TRRNIVL------------CLR----------NPKDPNEG 1095 Drosophila wi...
Q9VWZ4        980 EKNYVM---EMHCYACLSTLAQSHNFSWSRWN--Ll---aGSRTAVL------------LVReli-----egK----KVP 1030 fruit fly
XP_001983474  409 PLNLKLg-pHEVNLRYFNMIGGLYSLFFVPKPKHTh---fQKFNITLhkdgri-lhrseEVLadm----gdvGEKTDHRS 479  Drosophila gr...
XP_001983475  392 PRHLKLt-sDEVNMRQHIMLGGLYSIMFVRQTPGTh---yEKFNIMLhedgri-lhimdDIVadlra-ptwaDDVSARRS 465  Drosophila gr...
XP_001870057  305 PDSLSLageEHVNLRRFRITGGTFSVSRFQKLPQPtelssDFIYTTLpadlql--------------------------- 357  southern hous...
XP_001956983  398 PKHISLm-pKDLNMRAHIIAGGIYSLMVVRRPEQTa---yQNLSVLLhedqrk-iknlaDVVcrtdfkgqsmSLRVSEFV 472  Drosophila an...
EDW44295      395 PGNMNLl-pSEVNLRRFIIIGGIISLVFVRKAKHSs---yEKFNITLhkdgrvlskslnILDessteessmqPTKLDIGT 470  Drosophila se...
XP_017864476  674 QKHLAT---ELHVYDAFAIHCKLIKFYRCDWNRLA-----PRRNILL------------CLR----------NPKDVNDG 723  Drosophila ar...
XP_001983474 1024 VKHLAA---ELHVYDAFAVHCKLVKFFRSDWNRLS-----TRRNIVL------------CMR----------NPKDLNEG 1073 Drosophila gr...
XP_002012193  498 RFNYtqamespenrhLKLAPDEVSYFCVTFRLPKMLCLFGEPVVC 542  Drosophila mojavensis
XP_002068326 1096 AEVT-----------CRVTPDNSTFVEVSELCSDDLDVFKLHYQP 1129 Drosophila willistoni
Q9VWZ4       1031 YYST-----------LLVTPLKTSIIDCTEVSASFNAVGIPGMEY 1064 fruit fly
XP_001983474  480 PLTRrsayedaknlnLKLQDDELPFFWITFQLPEYLCRFGEPLAC 524  Drosophila grimshawi
XP_001983475  466 RLQMdeqk----rktLNIDETELPYFFVTIHMPRELCMWGDPIAC 506  Drosophila grimshawi
XP_001870057  358 ------------temqfVAETSEDFIKITVKLPTFCFWWHEPVVC 390  southern house mosquito
XP_001956983  473 RADQrn-------slFKLNESDLPYFHVTMKLPPDLCRWGTPKVC 510  Drosophila ananassae
EDW44295      471 DIMRdtevgeaskipLHLEPDELPYYFLTFKVPNHLCLWGEPVVC 515  Drosophila sechellia
XP_017864476  724 ADVT-----------IRVTPDNSTFVEVSEACTDDVDVIKLSYHL 757  Drosophila arizonae
XP_001983474 1074 A-VT-----------IRVTPNNSTFVEVSEPCSDNLETIKLAYQL 1106 Drosophila grimshawi
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