6W5R,7N4U


Conserved Protein Domain Family
Sterol-sensing
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pfam12349: Sterol-sensing (This model is not part of the current CDD release)
Sterol-sensing domain of SREBP cleavage-activation
Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Links
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Statistics
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PSSM-Id: 520220
Aligned: 21 rows
Threshold Bit Score: 159.29
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6W5R_A        649 LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIeVIPFLVLAVGVDNIFILVQAYQRDERLQGEt--lDQQLGR 726  human
P91346        298 WVVTKPILSVLGVSNAGMGIASAMGMLTYLEIQYNDIIA-VMPFLVVAVGTDNMFLMVASLKRTDRNLKY----DQRIAE 372  Caenorhabditi...
Q03602        288 IVKSQPFIGFFAMFNATMATIASTSLLLYLQYPFLPLVF-IMPFLVVSIGTDNMFLMLKSWRMTKKSSNE----EQRYIH 362  Caenorhabditi...
NP_788277     390 VFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTISLQSKdIFPYLVILVGLENSLVITKSVVSMDETFDV----KIRVAQ 465 
Q18968        295 MVASRWGLAFASSFTVASTLLMTTGICAHLDLSTTTWGSeVYPYIALIMGLENTLCITRSVVYTSPSLDV----SSRIAH 370  Caenorhabditi...
XP_011388979  410 KVHSRFGLAFTGTTQLIISMIMSVSICALLGIRLTLVPWeLLPFVIVVVGSENMYSLTKAIVDTPLSLTV----SSRIAH 485 
O43043        257 DIRAKFGLTATIFIQSGTAYFSTCSLLYFFERTGPICPWpMAYYIIIFMDIENSFRLLRAVIASPQTKRV----PSRIME 332  Schizosacchar...
Q2HB50        263 AVKSRVGLMVTMLAQITASIVSSFTVCAIFKVDLSHVPLqTYPFVILAISMENSFRLINAVIMTSSAISI----SDRIGE 338  Chaetomium gl...
Q23E28        595 KTHSGFLIGLAGIFIVIFSIVCSMGFMAFIGVGMTMISGeVIPFLILAIGVDNMFIISTAVKGCHGENL-----LEKIKG 669  Tetrahymena t...
EDO46942      879 RLRLKAWLGVAGVICVGLSIGVSFGMSSAFGVFYGPVHS-VLPFLLLGIGVDDMFVIVQAWNNLTPEEHKtkevHERIAL 957 

6W5R_A        727 VLGEVAPSMFLSSFSETVAFF-LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQ-EKNRLDIFCCVR 802  human
P91346        373 CMADAAVSILITALTDALSFG-VGTITTIPAVQIFCIYTMCALLLTFAYQLTFFCAILVYYTRIE-EQGLHSIWLRPA 448  Caenorhabditis ...
Q03602        363 ALTESAASLFLTSLTDGLSFA-IGSISDFHAVRVFCTYCAMAILFMFLFQVTFFNAVMSLCCRRE-VSGKHPVFCCYE 438  Caenorhabditis ...
NP_788277     466 ALSKEGWHISKTLLTEITILT-IGLATFVPVIQEFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTeYTAEAKHLPKML 542 
Q18968        371 GLSQEGYKLTKYYILELLALL-IGFLTRISDIQEFCQFSVICVTVDFYMQLFFYAPCLTFDLQRLgLEEKRKFAEILL 447  Caenorhabditis ...
XP_011388979  486 GLGKVGVPITLTTLADILLLLvIALFIEVRAVREFCIFAIFSLIMDWFLQMTFFVTVLSIDMQRLeLADLLTQGTRLS 563 
O43043        333 GFSSTIIASFSSLLKKLLTLFvLS-FFVYPLVQEFCLFLACSFVVSFLLHGSFFLAVLSVDIRRLeLQDFLDSNSSNR 409  Schizosaccharom...
Q2HB50        339 AFGTTAHIAIASPIQNSLILYgLS-KTGSLGVSSFCAFATIATFFDFFYLATFFLAVLSVDVRQReLCE-LEKASLKR 414  Chaetomium glob...
Q23E28        670 GMTEVGPSITAAAVSEILAFM-VGTFTNIPALTTFCIQAAIAVFFDYIFQITAFVAILAWDEERK-LKGICDVFVCIR 745  Tetrahymena the...
EDO46942      958 TLQHAGCSITITSLTDFLAFL-IGASTVLPGLQSFCIYAGLGILIDFILQITLFSAFLTLDGRREdRKRDGCCCCCIV 1034
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