Conserved Protein Domain Family
CLASP_N

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pfam12348: CLASP_N 
CLASP N terminal
This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.
Statistics
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PSSM-Id: 492563
Aligned: 46 rows
Threshold Bit Score: 182.022
Created: 16-Feb-2025
Updated: 25-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001642417  330 LSNDMINLLQPFqetKETEQNWKLRQANILKFREIVNGN-LPKKTPIEFISICKelqfiECISKAILSLRTTLSLGAFHL 408 
Q5BEN5          1 MDYKARDILSVL---KNVNLSVDAKVTHLLGLKSDIKQKnVPEKAVPVIFECLR-----HAIASPFHALYSAGFSTLGHF 72   Aspergillus n...
Q2UCC9          1 MEGKATELLAVL---KNNNLAIDVKVSHLLSIKSDIKQKnVPDNAVHLIFESLR-----LAITSHHAALYAAGFSTFGHF 72   Aspergillus o...
Q1DS65          1 MDARATELLATL---RNGNVSVDVKTTSLAKLKSEIKQKhVPDAAISPLFESFR-----LAIASQHYSLSSAGFSALGHL 72   Coccidioides ...
4_pfamImport    1 MDERATELLAAL---RNTSLSVDAKIASLTKLKSEIKQRnVPTSAVGDIFDAIR-----LAIASQHASLSAGGFSALGHL 72  
Q4WSI0          2 MEVKAAELVAAL---KNSNMSVDTKVAHLQCVKSDIKQKnVPEGAVPSIFESIR-----LAIASQHSSLSGAGFSTLGHF 73   Aspergillus f...
EEA25727        1 MEARATELLGTL---KNPNVSVDAKIAALTNVKSDIKQKnVPEPAVLPLFESLR-----VAISAQHSSLSSAGFSTLAHL 72  
2_pfamImport    1 MEPKATELVATL---KNLNLAIDAKVSFLNSVKSDIKQKnVSEGAIPPIFESLR-----LSIASSHSTLLSAGFSTLGHF 72  
3_pfamImport    1 MEAKAAELLAAF---KNPNLSVDSKIAYLSSVKSDIKQKnVPEGAIRPIFETLR-----LAVGSQHYSVLGAGFSTLGHL 72  
Q0D0S3         77 MDMKVDDLQAAL---TNPNLSIENKYDRLISVKSDIKQKnVPASLIPSLFDCLR-----LAIAHNNIHIYTAGFATLSHL 148  Aspergillus t...
XP_001642417  409 IREFCENLNQN-LDSQiIDQIFTTLKTSLSSTKKITSQNSLHSLVILLLNSNfsNKL-FNICFTLVNEKNVSPRICSSIL 486 
Q5BEN5         73 LKRLYIQEHHQlVAAM-SDRILPTLVDRMGDNKDRIRQQTTHALADLWEGAG--PQIeNLVLSVGFQGKNPFQKQTCLNL 149  Aspergillus n...
Q2UCC9         73 LKRLFIQDQAHiVSAY-ARHFCPVLLERLGDHKERVRAQAAQIFTDLWPAAS--ADVeHYVLEVALTGKNPKAKETSLIW 149  Aspergillus o...
Q1DS65         73 LKRLTLQEQHEaIALQ-GRATYQLLLERLGDHKERIRSQAAQAFTDFWPAAS--ADVeHHVLGAALIGKNARAKETSMVW 149  Coccidioides ...
4_pfamImport   73 LKRLYLQEQTAlIASQ-GRHTYSLLLEKLGDHKERVRAQASQAFADFWQASP--TETeHHVLEVALVGKSPRAKETSMMW 149 
Q4WSI0         74 LKRLLIQELHHlVALQ-CRALYPLLVERLGDHKERIRAQAAQSFTDMWLAAP--EEVeQCVLGQALVGKNPRAKEMSMIW 150  Aspergillus f...
EEA25727       73 LKRLYIQENHH-LVLFhARQLYPICLERLGDHKERLRAQASQAFTDLWIAAP--QDVeAHVLGTALVGKNARAREMSMIW 149 
2_pfamImport   73 LKRLFIQEQHSiVASQ-ARHLYPLLLERLGDHKERVRAQAAQAFTDFWPAAS--HEVeQHVLGTALVGKNNRAREMSMIW 149 
3_pfamImport   73 LKRLAIQEQQQwIVHQ-AHSLYPILLERLNDPKERIRAQAASIFTELWPFAG--NEVeYHVLEVALVGKNHRAKEMSMLW 149 
Q0D0S3        149 LKRLFIEELHTeVAAH-ARSLYPTLLERLGDHKERVRALAAQAFADLWKAAP--MDAeKHVLGTALVGRNPKAKEASLTW 225  Aspergillus t...
XP_001642417  487 LRLILIRFNns-------vDNERRLDNLNLF--IEEWLIKGIADAQTSVRESMRLTFWYY------------------FK 539 
Q5BEN5        150 LSIAFTRSE----------ITAAYAEATAk--eYLPQIISFVEDADPTVRQGARALLVQMfigerdsskhelkraleqYK 217  Aspergillus n...
Q2UCC9        150 LSNMSRNHG-------------------LLFrsYVPSVVSCLEDADSFVRHTAKSTVVEL------------------FQ 192  Aspergillus o...
Q1DS65        150 LAKMTREYG-------------------LLFriYVPALVTCLEDADGVVRDTAKSTVIEL------------------FQ 192  Coccidioides ...
4_pfamImport  150 LVKMTKERG-------------------VLFraHVPSLVVGLEDADSAVRETAKAAVIEL------------------FQ 192 
Q4WSI0        151 LSNVSSSFNiggfssfltiALQMTKNYGLLFrsYVSSLVACLEDADSNVRNTAKNTVIEL------------------FE 212  Aspergillus f...
EEA25727      150 LATMTREHN-------------------ILFrsHVPSLVAALEDADSGVRDTAKTTIIEI------------------FQ 192 
2_pfamImport  150 LANMAKQYG-------------------LLFrpYVPSLVACLEDADSAVRDTAKATIVEL------------------FQ 192 
3_pfamImport  150 LANMTKNHG-------------------LLFrqYVPSLVSCLEDADSAVRDTAKLVVIDL------------------FR 192 
Q0D0S3        226 ILSMHTSHD-------------------LLFrpYVASLVACLEDADSAVRDTAKSTVVGL------------------FN 268  Aspergillus t...
XP_001642417  540 CYPSNARKLLt-DSFSSQLKKAIE 562 
Q5BEN5        218 VRPSHAREILagIGLDPELYDESH 241  Aspergillus nidulans FGSC A4
Q2UCC9        193 GAPARAKADLtkEMTAQNVRQSIV 216  Aspergillus oryzae RIB40
Q1DS65        193 SAPPRAISDLkkQLIQNNVRKSIA 216  Coccidioides immitis RS
4_pfamImport  193 NAPSRAISDLkkQIQSHNVRRSIT 216 
Q4WSI0        213 NASERAKSDLkrQMATHNVRKSFV 236  Aspergillus fumigatus Af293
EEA25727      193 NAPSRAKSDLkrQLSEHGVRKSIV 216 
2_pfamImport  193 NAPAHAKADLkkQLSELNVRKSIV 216 
3_pfamImport  193 NGPARAKSDLqkQMAARSVRKSIA 216 
Q0D0S3        269 SAPAHAKADLqrEMAEQHVRKSIV 292  Aspergillus terreus NIH2624
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