Conserved Protein Domain Family
HJURP_mid

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pfam12346: HJURP_mid (This model is not part of the current CDD release)
Holliday junction recognition protein-associated repeat
Vertebral Holliday junction recognition proteins carry an SCM3 domain at their N-terminus as do the eukaryotic fungi, but they also carry this central, conserved region. The function of this family is not known. Further downstream there is also a repeated domain, also of unknown function. Investigation of Scm3 and associated proteins is likely to be directly relevant to understanding the mechanism of HJURP-mediated CENP-A chromatin assembly at human centromeres.
Statistics
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PSSM-Id: 520219
Aligned: 12 rows
Threshold Bit Score: 144.933
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001178742 254 MSRLLRSKPSCIISTKT-SINRNWKLKRRLsrKHGVHKNTTYCHRSKPFQRSSRKGPLHCSEPRKEARVLRDSKNLPHVD 332
EHB11957     249 MSRLLSAKPSCIISTKT-FIVQNWSSRRRQprRSGVQMNETYCKGARPSRRSTKERSTPYPEPRRERGTVGDSRNLPHVP 327
XP_007651789 259 MSRLLSLKPSCIISTKT-YINQNWNPRRRLsqKSRVHMNRTYSHRSKPFQRSSKKGPS--SKPGKE--VLRDCKNLLHTA 333
XP_006529784 178 MSRLLRSKPSCIISTKT-YINQSWKLRRRPsrKQGLHKNRTHCPRSKPSQRSARKGPASCSEPGKEAGILRDYGNLLHVA 256
XP_051690128 252 MSRLLSAKPACVISTRA-SVLQAWSCRRRH--RWRSRLNRTYCEAGRRSRGSSLHPPLPGPEPEPGAGPLRDCENLLDVS 328
2_pfamImport   1 MSRLLSAKPSCIISTKT-FI-QNWHCRRRS--GWKSRMNRTYCKGGRHTQRGPEEQRSPYSKPAKEVGTLNDPKNSLDVS 76 
3_pfamImport   1 MSRLLSTRSSGIISTKT-FIMQNWNSQRRH--KCK-RMNRTFCRGARRPQRGSRERPSPHSEPGKERGALRDCKNLLDVS 76 
XP_028687088 264 MSRLLSTKPSSIISTKT-FIMQNWNSRSRH--RGKSRMNKTYCKGARRSQRSSKENFVPCCEPVKDTGAIRDCKNVLDVP 340
XP_034511332 138 MSRLLSAKPSCIISTKTsFIAHSWSSRRRH--RCKNRMNKTHCRGSGPSRRGSQDRLPPWSEPLKDGEVLRDCENLLDAS 215
1_pfamImport   1 MSRLLSTKPSCIISTKTsFIAHSWNSRRRH--KCKSRMNRTRCRGAGPSRRGPQDRLPPCSEPGKNREVLRDCENVLDAS 78 
4_pfamImport   1 MSRLLGARPSCIISTKT-LIGQNWSSRRRH--RYKGRMNRTSCQGGGRSQRSPRERRPPCSKPLEDAGTLRDRGNLPDVS 77 
XP_001925760 262 MSRLLGARPCCIISTKT-FIGQNWSSRRRH--RCKSRMNRTSCRGGGRSRRSPRESRPPASEPRKHTAVLRDCENLLDVS 338
NP_001178742 333 PHktdKTGLELESVPLEGSKLQVHKLSPAWKE---LQGLPQKYL 373
EHB11957     328 CP---KTGFELEKAFLDENKPQLHKFDPSWKE---LQVTPRKRS 365
XP_007651789 334 P----KTDLKLERGSLEGSKLQVYKFNPAWKE---LQVMPQKYL 370
XP_006529784 257 PH---KTGLELKSVSLEGSKRQVHKSSPAWKE---LQMMPQKDL 294
XP_051690128 329 RR---KAGFKLERACLEGNKSQVQTSDPGWKE---LQLTPRRNS 366
2_pfamImport  77 CR---ERGFRLKKALLEVNNRQVHELVPTWKD---PKVTPQKYS 114
3_pfamImport  77 CH---NTSLKLRKAYLEV-KPQVHKLDPSWKElqvLQVTPKKCS 116
XP_028687088 341 CH---TTGLKLEKAFLEVNKPQIHKLDPSWKE---LKVTPSKYS 378
XP_034511332 216 GR---KVGLKLEKAFPEVNKPEIRKLNPSWKE---LRGLRSLMP 253
1_pfamImport  79 GQ---KADLKMEKAFPKVNKLKVCKLDPSWRE---FKGLRSLMS 116
4_pfamImport  78 AP---KTGLKSERALLKVNKPQIHTFSPPWKE---LQGMPRKHS 115
XP_001925760 339 GH---KTGLEEGPSFLGVSKPHPPAFAPSWKG---LQRTPPKLS 376
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