5OGS,8B9D


Conserved Protein Domain Family
Mcl1_mid

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pfam12341: Mcl1_mid (This model is not part of the current CDD release)
Minichromosome loss protein, Mcl1, middle region
Mcl1_mid, or the middle domain of minichromosome loss protein 1, is the domain that lies between a 7-bladed beta-propeller at the N-terminus, family WD40 pfam00400 etc, and a Homeobox (HMG) domain, pfam00505, at the C-terminus. The full length proteins with all three domains are referred to as DNA polymerase alpha accessory factor Mcl1, but the exact function of this domain is not known.
Statistics
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PSSM-Id: 520217
Aligned: 102 rows
Threshold Bit Score: 197.794
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OGS_A        107 KPFQSGSTpLH--LT-HRFMVWNSIGIIrcy-ndEQD-----NA-IDVEFHDTS----IHHATHLS-NTLNYTIADLSHE 171  human
XP_003100456  452 APVDPEAT--------QRFLKYNRFGIVrsyvndANk-----VStLDIEFHDKS----IHGDIHIDnFEIGYELADISLK 514 
Q19520        447 SPMDLDAT--------QRFLKYNRFGIIrsyvneANk-----VStIDIEFHNKS----IHGDIHIDnFEINYELADISLK 509  Caenorhabditi...
XP_002184268  592 PAFGPSSTsLE--LT-RRFLCWNHIGSVtf---lRGQaginrST-IDIHFTDSA----FRRPVSFT-DNMGFILGSLGED 659 
XP_002292239  158 KTFAPSSTpIT--EP-RRILCWNHVGVVts---yPDPespqyST-IDIAFHDAAglvgGRRPVTFM-DNLGFIVGTLGDE 229 
XP_003392327  588 YSFQVGATpAG--EEgNCYLAYNSVGYIhcs-----------rdaTTVHFHDIS-----HPAVRLQ-LRGTVLMGTLSPV 648 
Q4E5R7        564 YSFQIGATpVG--EEgSCYLAYNSVGYIhst-----------adgTNIHFHDMS-----IQAVRIL-ERGTILMAALSPV 624  Trypanosoma c...
XP_001307710  545 gPFMPGSSqdy--dgsRRFLCWNETGVIflreidEDr-----EA-IDVEFADVF----SNRNVSFS-NDRHFLLATLNKE 611 
XP_012654825  475 diiyPSSVsKQ--LN-RSCILWNLVGQIilreedRNLf-------LEFDFPDKE----FHSRITIK-NLHNYSMAAMNRQ 539 
Q8IER6        773 iVLAPGLCeepenindQWCMFWNDIGHItkkkegSK-------TyIYIFLFRGE----EIGKKKIT-DIYNVTSASLSAY 840  Plasmodium fa...
5OGS_A        172 AILL-ACESTDE--L--------------------------------ASKLHCLHFSSWDS--SKEWIIDLPQNEDIEAI 214  human
XP_003100456  515 VVAL-ASLENRKkeKeldkaedeledl---------dtndtpkekkgTSILHVIPIQAFDG---HRWTMTLPRGDGCLDV 581 
Q19520        510 VVAL-ASVESRKkeKeldkanddiedl--------etdepaktekkgTSLLHVIPIQAFDS---QRWSMVLPRGDGCIDV 577  Caenorhabditi...
XP_002184268  660 GGIF-ATDLAEDedIdeedddmdglnvsaatkaavkrsrkgpsnkptGSSIYFHRFETFGSlrDKDWYLTLPDGERALGC 738 
XP_002292239  230 GAFF-ATD------Kggs--------------------------gnkGSQVYFNRFETFGRnaDKDWSVSLPSGERVLGC 276 
XP_003392327  649 GAAFiVLPADPTeaQgsvd-------------------------eapRLSVLYHAFTPLGA--QSEWRVALLPGETVRCM 701 
Q4E5R7        625 GAAF-VLTQDAe-mDsvd--------------------------dtpRLTLYYRTFVALGA--QSDWRVRLYPGETVRCL 674  Trypanosoma c...
XP_001307710  612 GFCA-A------------------------------------------SRTYFQYRSNNPKsiPSEFSHKFTDSETIDLI 648 
XP_012654825  540 GFIL-ASKAINSsqEyeseedfer--------------fdfhqdaysYSCIYFQSLSKSDK---TLWSLKLGQDENVETV 601 
Q8IER6        841 GFALaSNPYEKSgnKn-------------------------------NSILCFHNLKDN-----IIWNKYLPSDEYIKGV 884  Plasmodium fa...
5OGS_A        215 CLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQ------------LFIVYHRGTG-----FDGDQCL-- 275  human
XP_003100456  582 LCSSTQIVVLTKKRNIRVFTIGGIQRQIFTHPSPILTATCFENR------------IAIASVAGSEfyeqkKTPQWRFev 649 
Q19520        578 LCSNTQVVVLTKKRNIRVFTIGGIQRQIFTHFAPILTAACFEDR------------LAIASVCGSEfyeqkKTPQWRFev 645  Caenorhabditi...
XP_002184268  739 ASGEGWAAVVTSRRFLRLFSSGGNQGEVLWLNGHPVTMAGRGRF------------VAVVYHESTPl----PDGTQKL-- 800 
XP_002292239  277 ATGRGWGAVMTSRRYLRLFTTAGIQGPVLWLSGEPVTVVGRDRF------------VAVFYHRSDPt----QDGTQQL-- 338 
XP_003392327  702 AAGIRYVAVAT-SHYLRIFSLSGLELAVLSKSQRIVTMVGTSSRklmssfkadfdpLVIIS----------LTGTGEL-- 768 
Q4E5R7        675 TAGIRFTAVAT-SRYLRLFSLSGLELAVLSLFPRIVAMVGTNSSkimhsfkadfdpLAVCY----------LESGGEM-- 741  Trypanosoma c...
XP_001307710  649 AIGKRWVAVATELGRIHIFKSSGFEYASLSLPDRLLTMVGGKDR------------LFVVF-------------GDTL-- 701 
XP_012654825  602 AIGDGWCAVQTDLQYIRIYSFSSMEQHCFCIDKPAVCISGYKNI------------LAIVYLEGEP-----IYGCQSI-- 662 
Q8IER6        885 ANGNNFVAVVTSNNFLRIYSTYGYIINTILLKGLPVAICAYDYL------------LFIITCPYIYenvttTNINNTYtc 952  Plasmodium fa...
5OGS_A        276 -GVQLLE--LGKKK------K---QilHGDPLP-LT----RK-------SYLAWIGFSAEgTPCYV-DSEGIVR--MLNR 328  human
XP_003100456  650 tEYSLDQ--KSWYResrsrgAtgaI--TRIDVP-VE----TG-------EQMDWLAYSSQgKLAVM-DSAYNVH--VLSa 710 
Q19520        646 vEYTLNP--KSWYRenrhhgStgaV--SRIDVP-IE----TG-------EQLDWIAYSNQgKLAVM-DSAYTVH--VLSa 706  Caenorhabditi...
XP_002184268  801 -GYLVLD--AMANR------V---V--AKGPVScIS----GA-------STLSWLGFSNDgSLLAM-DSDGMLS--MLVC 852 
XP_002292239  339 -GYSIID--GINGT------T---I--TKGDVSgIS----PG-------GSLTWAGFTEVcALSVM-DSDGMLS--ML-A 389 
XP_003392327  769 -QMEVIDv---------------gA--RTSALP--PrtvpLTelpdgstHQLQWLGWSEDg-LLHIvDTAGVVR--QFTE 825 
Q4E5R7        742 -RLQVLDv---------------gS--RSVVLP--PvvvpLTthsdgslHQLQWMGWSEDg-PLHFaDTAGVLR--MFTF 798  Trypanosoma c...
XP_001307710  702 -DYWLLDipNri-----------kL--ASGVIP-V------A-------KPLRWVTFDEN-DNVYAlGNDKILVelVFDf 752 
XP_012654825  663 -KLKFFD--VNSGE------M---I--KEIGVP-LT----PF-------TTLTWFGFSEEg-LVLTkDSKGVIR--ALIg 713 
Q8IER6        953 tLYKIYEnfTNLKPskyntyHitiL--YEDVLS-LP----SC-------HYLNWVNMSNFgVPYVK-DTSNYIY-----G 1012 Plasmodium fa...
5OGS_A        329 ----Glg------ntWTPI------------------------------CNTREhCK---G-K-S--------DHYWVVG 355  human
XP_003100456  711 p------------glWVPV------------------------------FQGSSiLRak-------------sDGIFPLA 735 
Q19520        707 p------------glWIPI------------------------------FQGSSaLRap-------------sDAIFPIG 731  Caenorhabditi...
XP_002184268  853 asslDaegptekhweWMPM------------------------------LDTVG-LRk--S-R-D--------DSFWPVT 889 
XP_002292239  390 rp-aPteqpsinignWVPM------------------------------LDTMG-LKk--L-M-S--------DIYWPVE 425 
XP_003392327  826 dw-gGs---------WVPV------------------------------YDPRTlVDqsyA--------------LWVYG 851 
Q4E5R7        799 nw-gGs---------WIPV------------------------------LDPRCmADqtyN--------------LWIWG 824  Trypanosoma c...
XP_001307710  753 g------------fhWQAMsnlrnvisegkveenenksdesdesdlgldIDKKKsTNddgSyQlDhaekeiytD-FWCVS 819 
XP_012654825  714 y------------snWTPI------------------------------YEQPH----------N--------KNFWLKG 733 
Q8IER6       1013 ly-pIfkknnqlvydWVPV------------------------------FDMQIlNDlenKeN------------MLQLN 1049 Plasmodium fa...
5OGS_A        356 IHE-----------------------------NpqQLRCIPCK-Gs---rFPPTlPRPAVAIL------SFKLP 390  human
XP_003100456  736 LTA-----------------------------K--EFRYIYCR-Gs---rSPIVsGINAPTTI------EWKVP 768 
Q19520        732 LTV-----------------------------K--EFRYIYCR-Gs---rSPLVnGINAPTTV------EFKVP 764  Caenorhabditis elegans
XP_002184268  890 VYD-----------------------------G--KLVCVPLK-Ggm--kHPDAvRRPVTAAL------GFRLP 923 
XP_002292239  426 VHG-----------------------------G--KLVCVLLR-Ggr--eYPDAaRRPVTTTL------SLRIP 459 
XP_003392327  852 VSE-----------------------------S----ALLAYRySrddpsYPAAaASGLSTEL---------VP 883 
Q4E5R7        825 VSD-----------------------------E----AVFAYRsCksdppYPAAvASGLPTehvrlflpltrcg 865  Trypanosoma cruzi
XP_001307710  820 ISD-----------------------------N--KLFGCFLK-En---kVPHAyPLQGLSEV------Klmpl 852 
XP_012654825  734 MVD-----------------------------Y--KLAGFLLP-Kd--------eLEPRLTQIyhekcfDMQLP 767 
Q8IER6       1050 ENNqhilnetinknditsndihsqkddnedyiN-----------SnmknaTPSK-----------------LNP 1095 Plasmodium falcipar...
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