Conserved Protein Domain Family
SOXp

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pfam12336: SOXp (This model is not part of the current CDD release)
SOX transcription factor
This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00505. There are two conserved sequence motifs: KKDK and LPG. This family is made up of SOX transcription factors. These are involved in upregulation of nestin, a neural promoter.
Statistics
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PSSM-Id: 520214
Aligned: 12 rows
Threshold Bit Score: 62.955
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005798102 106 YRPRRKTKTLLKKDKYSLAGGLLSG-----------PSGGGGVGLsvgmsssGVG--------QRLEspgghggsagsGY 166
Q9PT76       104 YRPRRKTKTLLKKDKYSLPGGLLAP-----------GANAVNNSV-------SVG--------QRMD-----------GY 146 Japanese medaka
2_pfamImport   1 YRPRRKTKTLLKKDKYSLPGGLLPHgp------------------------vGVG--------QRLD-----------TY 37 
Q68FA4       109 YRPRRKTKTLLKKDKYSLPGNLLAP-----------GVSPVASSV-------GVG--------QRID-----------TY 151 tropical clawed...
Q6NVN0       106 YRPRRKTKTLMKKDKYTLPGGLLAP-----------GANPMTS---------GVGaslgagvnQRMD-----------TY 154 tropical clawed...
1_pfamImport   1 YRPRRKTKTLMKKEKYPLPGGGGPLslg------gaGGQPCDNSVggrnavaQVSgvtqqqlnNSRD-----------LY 63 
5_pfamImport   1 YRPRRKTKTLMKKDKYPLTTGSLIPnnsvdparssaNNTGVQQVVsr------------------------------dmY 50 
Q9Y0D7       130 YRPRRKTKTLLKKDKFTLPGIINPQ-----------TGAPVQRGVgdg----------------------------mhGY 170 purple sea urchin
6_pfamImport   1 YRPRRKTKTLMKKDKYALPGGLLAP-----------GGGGVGVGVgv---gvGVGsgvgagmnQRMD-----------GY 55 
Q6DGL6       106 YRPRRKTKTLLKKDKYSLAGGLLGG-----------AGGGvgm------spaGVG--------QRLEspgghggsasaGY 160 zebrafish
XP_029699279 106 YRPRRKTKSLLKKDKYSLAGGLLSG-----------PSGGGGVGLgvgmsssGVG--------QRLEspgghggsagtGY 166 torafugu
P48430       108 YRPRRKTKTLMKKDKYTLPGGLLAP-----------GTNTMTTGV-------GVGatlgagvnQRMD-----------SY 158 chicken
XP_005798102 167 AHMNGWA-NGAYsgqvaaaaaaaAMM-----------QEaQLAYSQHPGSGAhhhhhshhhhsHNPQPM-HRY 226
Q9PT76       147 AHMNGWT-NSAY-----------SLM-----------QD-QLAYPQHPSMNS-----------PQIQQM-HRY 183 Japanese medaka
2_pfamImport  38 AHVNGWA-NGAY-----------SLV-----------QE-QLGYAQPPGMSSqp-------ppPALPQM-HRY 78 
Q68FA4       152 AHMNGWT-NGAY-----------SLM-----------QD-QLGYSQHPGMNS-----------PQMQQIqHRY 189 tropical clawed frog
Q6NVN0       155 AHMNGWT-NGGY-----------GMM-----------QE-QLGYPQHPGLSAhn--------aPQMQPM-HRY 194 tropical clawed frog
1_pfamImport  64 HQMNGYMpNGGF-----------GMH-----------HDpN-PYAQQPSPYAsh--------mAAASQAa--- 102
5_pfamImport  51 QMPNGYM-PNGY------------MM-----------PDp-SAYQQHTAYSSh------------mASGyPRY 86 
Q9Y0D7       171 QHLNGYM--NGYp----------SMM-----------QD-QLSHLPSHSYGAhqa------aqMANSGLhHRY 213 purple sea urchin
6_pfamImport  56 AHMNGWS-NGGY-----------GMM-----------QD-QLGYAQHAGLNApm-------qtSATAPV-HRY 96 
Q6DGL6       161 AHMNGWA-NGTYsgqvaaaaaaaAMM-----------QEaQLAYSQHPGSGShhhha-hhhhpHNPQPM-HRY 219 zebrafish
XP_029699279 167 AHMNGWA-NGAYs----------GQVaaaaaaaammqEA-QLAYSQHPGSGAhhhhs-hhhhtHNPQPM-HRY 225 torafugu
P48430       159 AHMNGWT-NGGY-----------GMM-----------QE-QLGYPQHPGLNAhn--------aAQMQPM-HRY 198 chicken
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