Conserved Protein Domain Family
SOXp

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pfam12336: SOXp 
SOX transcription factor
This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00505. There are two conserved sequence motifs: KKDK and LPG. This family is made up of SOX transcription factors. These are involved in upregulation of nestin, a neural promoter.
Statistics
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PSSM-Id: 403523
View PSSM: pfam12336
Aligned: 17 rows
Threshold Bit Score: 36.7533
Threshold Setting Gi: 124430775
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_017265803 104 YRPRRKTKTLLKKDKYS-LAGGLLSG-----------PSAGGGVGLsvgmsssGVG--------QRLEspgghggsagsG 163 mangrove rivulus
XP_001520781  39 YRPRRKTKTLLKKDKYS-LPANLLAP-----------GAGAVGSPV-------AVG--------QRLD-----------G 80  platypus
Q9PT76       104 YRPRRKTKTLLKKDKYS-LPGGLLAP-----------GANAVNNSV-------SVG--------QRMD-----------G 145 Japanese medaka
NP_001074465 106 YRPRRKTKTLLKKDKYS-LAGGLLHA-----------AGGG---HMgvglspgGGGggtggvvvQRLEspgsg--asagG 168 tropical clawed...
Q9Y0D7       130 YRPRRKTKTLLKKDKFT-LPGIINPQ-----------TGAPVQRGVgdg----------------------------mhG 169 purple sea urchin
EEN49032      80 YRPRRKTKTLMKKDKYS-LPGGLIAA-----------NGAPVQRTIatg----------------------------mdQ 119 Florida lancelet
3_pfamImport   1 YRPRRKTKTLMKKDKYP-LTTGSLIPnnsvdparssaNNTGVQQVVsr------------------------------dm 49 
XP_002592066  87 YRPRRKLKTMMKNSSFPtMPGGMPPNyfpa---sncsPPPALQMSMp-------------------------------eQ 132 Florida lancelet
Q68FA4       109 YRPRRKTKTLLKKDKYS-LPGNLLAP-----------GVSPVASSV-------GVG--------QRID-----------T 150 tropical clawed...
XP_006875033 130 YRPRRKTKTLLKKDKYS-LPGGLLPPgaaaaaaaa----------aaaasspvGVG--------QRLD-----------T 179 Cape golden mole
XP_017265803 164 YAHMNGWA-NGAYsgqvaaaaaaaAMMQEaQLAYS----QHPGSGAhhhhhshhhhsHNPQPM-HRY 224 mangrove rivulus
XP_001520781  81 YAHVNGWT-NGAY-----------SLMPD-QLGYP----QHPAMGG-----------PQLPQM-HRY 118 platypus
Q9PT76       146 YAHMNGWT-NSAY-----------SLMQD-QLAYP----QHPSMNS-----------PQIQQM-HRY 183 Japanese medaka
NP_001074465 169 YAHMNGWA-NGAYpgsva-aaaaaAMMQEaQLAYSqqqqQHPGSGG----------------H-HPh 216 tropical clawed frog
Q9Y0D7       170 YQHLNGYM--NGYp----------SMMQD-QLSHL----PSHSYGAhqa------aqMANSGLhHRY 213 purple sea urchin
EEN49032     120 YAHMNGYMsNNAYt----------HMMHQdQLHAY----PHPGISPaqta----sqmASNASLpPRY 168 Florida lancelet
3_pfamImport  50 YQMPNGYM-PNGY------------MMPDp-SAYQ----QHTAYSSh------------mASGyPRY 86 
XP_002592066 133 YGHMNGYM--SGYh---------sSMMRDpANPYS----HQVIPSSaa--------aTTAGSMpTRY 176 Florida lancelet
Q68FA4       151 YAHMNGWT-NGAY-----------SLMQD-QLGYS----QHPGMNS-----------PQMQQIqHRY 189 tropical clawed frog
XP_006875033 180 YAHVNGWA-NGAY-----------SLVQE-QLGYA----QPPGMSSpp-------ppPALPQM-HRY 221 Cape golden mole
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