Conserved Protein Domain Family
SBF2

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pfam12335: SBF2 (This model is not part of the current CDD release)
Myotubularin protein
This domain family is found in eukaryotes, and is approximately 220 amino acids in length. The family is found in association with pfam02141, pfam03456, pfam03455. This family is the middle region of SBF2, a member of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may also convey control of myelination. Mutations of SBF2 are implicated in Charcot-Marie-Tooth disease.
Statistics
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PSSM-Id: 520213
Aligned: 21 rows
Threshold Bit Score: 300.8
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC05449      527 GPSMAQVASQD-SVVSNSARRLEVLCNCINHVFDNKISDARKAMPAVLRALKSKAARLALTHELQHHVTGNKAVLEHQQF 605 
9_pfamImport    1 GVHISNVVDSRqQLVSNSARRLEVLKNCINCIFENKISDARKSLPAVLRALKCRVTRLALCTELDNHVIGNKAMLEHQQF 80  
XP_046438357  547 GPPLSGLQDSR-HLFNNSARRLEVLRNCINCIFDNKISDARKTFSAVLRALKTNDSRLALCTELGHHVAGSRAILDPAQF 625 
XP_002422691  546 GPHISTISDNR-PGISDSARRLEVLKNCINCIFENKISDARKTFPAVGRALKSKAARLALCSELSQHVVGNKAMLEHQQF 624 
XP_011256263  557 GPHISFIHDTR-HLVSNSARRLEVLRNCINCIFENKISDARKTFPAVLRALKSKAARLALCMELSQHVVGNKAMLEHQQF 635 
XP_008191605  541 GPHISNLNENK-NIVSNSARRLEVLRNCINCIFENKISDARKTFPAVLRALQSKQARLALCNELAQHVSGTKAMLEHQQF 619 
XP_002107707  567 GMKLTGAL---------MLKRLEVLRKCVSNIFNNRIIEAKKMFSAVLSLLTSVQYRIALVEEFESYCLHSRVVLTFDQF 637 
XP_002000572  562 GPRLPEALELRpTTVHNSARRLEVLRTCVSYIFENRIADARKLLPAVMRTLKHRDARLILCRELFGYVHGNKAVLDHQQF 641 
XP_009016481  542 TRLTHSQVEKA-QLVSTNARRLEVLRNCITFIFENKISDARKIIPAVLKVLKTKVARLLLVEELGFHVKSNRSLLEHQQF 620 
1_pfamImport    1 GPPITNSNDLR-TTVSNSARRLEVLRNCVNCIFENKISDARKTFPAVLRALKCRAARLALCTELAQHVQGNKAMLEHQQF 79  
EEC05449      606 DLVVRLMNCAL-QDDSALDEHGVAAGILPLSHAFCRKLCTGVMQFAYTCIQDHVVWGQLQFWEAAFYQDVQRDIRSLYLP 684 
9_pfamImport   81 DLVVRLMNCAL-QDVSPLDEFGVASSLLPLATAFCRKLCTGVIQFAYTCIQEHAVWQNQQFWEGAFYQDVQKDIKALYAQ 159 
XP_046438357  626 DLVVRLLNCAL-QDTSVMDEYGVAAAILPLATSFCRKLCTGVVQFAYTCIQDHPVWQSQQFWEASFYQDVQRDIRALYLP 704 
XP_002422691  625 DLVVRLMNCAL-QDDSAMDEHGVAAALLPLSTAFCRKLCTGVIQFAYTCIQEHPVWQNQQFWESAFYQDVQRDIKALYLP 703 
XP_011256263  636 DLVVRLMNCAL-QDDSSMDEHGVAAALLPLATAFCRKLCTGVIQFAYTCIQEHPVWQNQQFWEDAFYLDVQKDIKRLYLP 714 
XP_008191605  620 DLVVRLMNCGL-QDDSSMDEHGVAAALLPLSTIFCRKLCTGIIQFAYTCIQEHAVWQNQQFWEAAFYQDVQKDIKALYTA 698 
XP_002107707  638 DMVVRLINQAL-QEDDANDRNGVAAMILPFSASFCRKLSDNVHQFAYTCVWDHPVWDNPRFWERTFYLTCQKHVMNLYEN 716 
XP_002000572  642 DLVVRFMNKAL-QNSSGVDEYTVAAALLPMSTIFCRKLSMGVVQFAYTEIQDHVIWKNLQFWESTFFQDVQAQIKALYLL 720 
XP_009016481  621 EMVVRLLNSALqQNDSVMDENGVATAILPLAMSFCRKLFTGVIQFAYTCVQDHPVWSSHQFWEAAFYQDVQQQISNDTTL 700 
1_pfamImport   80 DLVVRLMNCAL-QDGSAMDEFGIAAALLPLATAFCRKLCTGVIQFAYTCIQDHLVWKNQLFWESAYYLDVQRDIKSLYSD 158 
EEC05449      685 HTASPQHGGHQPNhqqpnnapgkqktpplspreskdstsswsridapkanfdlcnRRPAILSKAPEPSALEIAAEQMRIQ 764 
9_pfamImport  160 TSNMEFRIANQPVsdlglkm----------------------------ptvyfryPKASQGVKGQEPSALEIAAEQMRIC 211 
XP_046438357  705 RSDSN--------------------------------------------------NTDTIQVTKFEMSVLEIAAQQMRRW 734 
XP_002422691  704 RMEINSlppsspr--------------------------------------dsrefpfRNYSRIQEPSALEIAAEQMRLW 745 
XP_011256263  715 GDNSPPRLINDGIlspispr----------------------------dgkefpyRDRYSIYQAQEPSALEIAADQMRIW 766 
XP_008191605  699 RCESVR---GELLssptspre---------------------------skdynwtNRRSILNRVHEPTALEIAAEQMRIW 748 
XP_002107707  717 SLIKKANKNA---------------------------------------------IEAKNDNKVEDVTAVETV------- 744 
XP_002000572  721 QRRQNEHNKEA--------------------------------------------NCVLDEVPLEEPTALEITAEQLRKS 756 
XP_009016481  701 RRNDSKRWSTFSL------------------------------------------NPPNNAAHQRSIAALEIAAEQMRLW 738 
1_pfamImport  159 NNLSSHKRSSSMNlsspre------------------------------nhnkdnILNDRFSRSQELSALEIAAEQMRLR 208 
EEC05449      765 QngSLSKEELEELASREESTVYSQAIHFANRM 796 
9_pfamImport  212 S--NINQEKIAELAGSEESTVYSQAIHYANRM 241 
XP_046438357  735 P--SMTIEQRLELEANEESTIYSQAIHYANRM 764 
XP_002422691  746 N--AYTPEKQQELVCSEESTLYSQAIHYANRM 775 
XP_011256263  767 P--SIDPEKQKELVNSEESTMYSQAIHYANRM 796 
XP_008191605  749 S--SIDGEKQKELITCEENTMYSQAIHYANRM 778 
XP_002107707  745 ---ETAINTDTENGKPKAETTFGTT------L 767 
XP_002000572  757 P--TIEEEKKAELAKSEESTLYSQAIHFANRM 786 
XP_009016481  739 P--NLSEEEKSEMIKNEESTVYSQAIHYANRM 768 
1_pfamImport  209 P--SNNSDKLKEYISSEESTLYSQAIHYANRM 238 
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