Conserved Protein Domain Family
TMF_DNA_bd

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pfam12329: TMF_DNA_bd 
TATA element modulatory factor 1 DNA binding
This is the middle region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures. The whole proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal and plant cells.
Statistics
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PSSM-Id: 372049
View PSSM: pfam12329
Aligned: 47 rows
Threshold Bit Score: 42.6787
Threshold Setting Gi: 156622372
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002491609  271 NNLQKKLEAKELQVKELLEEGMKLSSNEVSLLQTVKRLKQENNSLA--NELNNASeinRKLESRSQKLDALEKEFIKEE 347  Komagataella p...
Q75DU4        129 SSLLLLVKEKDARIEELLEEQQETSAKERRATQALSKMEKKYNKQV--AESAALE---QKLRKQASENVLLKEEKDKAK 202  Eremothecium g...
EEE61640       71 LQLENVVREKSAQIAALVSELEVLQVPNVADDESVLKANAHNEMLE--KQVLRLG---SDLEDQVKKGESLEARASEAE 144  Japanese rice
Q6FK79         97 SSVFKLIKGKDEEIAQLTKKLEDRRKQDTANEKLLSKLTADNEKLN--KNNDNLS---KKLNESNQEISNLQQKYSLSE 170  [Candida] glab...
CAO98778       95 VSVLKLVKGKDEEIDQLKKNVEKYERQENLGKLKIGKLKEAMEIAT--SSRDQLT---KELNLVVMEKDSLVSKLKEAE 168  Nakaseomyces d...
XP_002847892  282 KWMREDMESKEADIAELQ---EQLKSAESKQAEEVANLREEINELE--YTIREKD---RRIEEKEEEIENLQSKHADEN 352  Microsporum ca...
ACR50691        9 KGEAE-LNAKQAELAKKQTELEKLLDSLDPEGKTQDELDKEAAEAElnKKVESLQ---NKVADLEKEISNLEILLGGAD 83   Streptococcus ...
XP_001270700  540 LDLLATITEKDDQIEELQEESQDLRDDNDKLRQTLDMLSKENGATL--EQTAVLK---QEASRLQESVEQGRLLLGQKD 613  Aspergillus cl...
EEE64668      510 SDAAALLKEKDEIISQVMAEGEELSKKQAAQEATMRKLRAQVRELE--EEKQRLN---SKIQVEETKVESIKRDKAATE 583  Japanese rice
XP_001778871  300 SDSSMLLKEKDEIIKAVMAEGEELSKKQAAIEGTVKKLRAQVRELE--EEKNRLS---SKLQVEEAKVESMRKDKAATE 373  Physcomitrella...
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