6AHR


Conserved Protein Domain Family
Rpp20

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pfam12328: Rpp20 
Click on image for an interactive view with Cn3D
Rpp20 subunit of nuclear RNase MRP and P
The nuclear RNase P of Saccharomyces cerevisiae is made up of at least nine protein subunits; Pop1, Pop3, Pop4, Pop5, Pop6, Pop7, Pop8, Rpr2 and Rpp1. Many of these subunits seem to be present also in the RNase MRP, with the exception of Rpr2 (Rpp21) which is unique to RNase P. Human nuclear RNase P and MRP appear to contain at least 10 protein subunits, Rpp14, Rpp20, Rpp21, Rpp25, Rpp29, Rpp30, Rpp38, Rpp40, hPop1 and hPop5, although there is recent evidence that not all of these subunits are shared between P and MRP. Archaeal RNase P has at least four protein subunits homologous to eukaryotic RNase P/MRP proteins. In the yeast RNase P, Pop6 and Pop7 (the Rpp20 homolog) interact with each other and they are both interaction partners of Pop4; in the human MRP Rpp25 and Rpp20 interact with each other and Rpp25 binds to Rpp29 (Pop4).
Statistics
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PSSM-Id: 372048
View PSSM: pfam12328
Aligned: 40 rows
Threshold Bit Score: 63.8507
Threshold Setting Gi: 74582823
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6AHR_G        32 RRPNDIYVNMKTDFKAQLARCQKLLD-------------------------------GGARGQNACSEIYIHGLGLAINR 80 
XP_003437507  74 NRTQIIKVASSASHMSLVKRVRKALEsarnnqqgttkglpl-aarvaalgaknggsdQTGPISDALDDVVLIATGRAIQK 152 Podospora anser...
EDN93584      43 SSEKVIYVSHNSQFIAIVKRVRKYLDgaefragptvlpstdrelmeeieegikhsrmGKKAGGGKSEEVVMKGTGKAIEK 122 Sclerotinia scl...
EEA06805      20 LNRFDIFVTRKKPLIVYYRRALDLLLlsenantiyk------------nrigyrrnkNKLDISNEIPKVVIHGMGACINT 87  Cryptosporidium...
EDV27299      26 KRKNDVYVTRKTNFAAQIKKCSKLLEs-------------------------------------EFTEIHIHGLGAAVNR 68  Trichoplax adha...
EDO47971      12 KKKNDVYVNRRSDFAGQLERCQKLLDs-------------------------------------SHQEVWIHGLGAAINR 54  starlet sea ane...
Q5XJ22        46 KRRNDVYVNMKTDFKAQLARCQKLLDa--------------------------------------HREICIHGLGLAINR 87  zebrafish
Q9DCH2        32 RRPNDIYVNMKTDFKAQLARCQKLLDg-------------------------------GTRGQNACTEIYIHGLGLAINR 80  house mouse
Q9U1X8        29 SNPNHIYITRKTNVESQSKSTEEMLNn-------------------------------------AFDEVFIHGMGASINK 71  Caenorhabditis ...
XP_001902429  21 KEKNDIYITRHTSIAAQKGRIIKLLDe-------------------------------------KMDEVVLHGLGAAVSR 63  Brugia malayi
6AHR_G        81 AINIALQL--QAGsfGSLQVAANTSTVELVDELEPET----DTREPLTRI--RNNSAIHIR 133
XP_003437507 153 AVEVGASF--TRE--RDLIVIARTRTVQAVDDIEMMDe--dAEEEDSARV--RHVSCVEVG 205 Podospora anserina S mat+
EDN93584     123 TLMLANWW--QQQ--EGVRVVVRTKSIAAVDDIVGVDnadeDMGEGESRV--RRVSVLEVA 177 Sclerotinia sclerotiorum 1980 UF-70
EEA06805      88 AIWLVQDLktNFG--DNIKETIETKTIEVIDDYITED----FEWDMTSKK--RGVSAISIT 140 Cryptosporidium muris RN66
EDV27299      69 AINLALQLklTSS--GGLEVSTTTSTVELFDDFESL-----DETLPSKKSqlRQNSAIHIK 122 Trichoplax adhaerens
EDO47971      55 AINLSLQLkqRGM--GSVEVSPKTSSVQLVDDLEPEN----DEDERHTRT--RTNSAIHIR 107 starlet sea anemone
Q5XJ22        88 AINIALQLqtSSQ--GALQLAANTSTVELIDDLEPEDp--dEAGEHLTRT--RNNSAIHIK 142 zebrafish
Q9DCH2        81 AINIALQLqaGSF--GSLQVAANTSTVELVDELEPET----DSREPLTRV--RNNSAIHIR 133 house mouse
Q9U1X8        72 ALVFAMEVerRFG--GSVKSDIQTSTVQCTDDIVSLL----DLDQSETRH--RSVSAVHVH 124 Caenorhabditis elegans
XP_001902429  64 TINVALQIqrKLV--DTVKIDVRTGTVKVTDNLFPLY----DEVDFKTRN--RFISAVHVR 116 Brugia malayi
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