Conserved Protein Domain Family
TMF_TATA_bd
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pfam12325: TMF_TATA_bd (This model is not part of the current CDD release)
TATA element modulatory factor 1 TATA binding
This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal and plant cells. The Rab6-binding domain appears to be the same region as this C-terminal family.
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Statistics
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PSSM-Id: 520205
Aligned: 76 rows
Threshold Bit Score: 84.5244
Created: 16-Feb-2025
Updated: 25-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_024326068  726 SVSTAGAGPSVQLVERMSAAVRRLENEKISTKEELVRLASQRDEARAEIVSLMQEVEAKRADHNRVLELEKEVDAINARY 805 
XP_046444223  829 lYDAMRAGSYTAVFESLQAQLKTRDGEVTQLQQELQNQERSRDSLAKELTEMINTNQELSHRLDRLETLLQEYEDLKTKY 908 
XP_002422748 1098 vydnLRCGNTTSLIENLQAQLKMRDGEIAQMTWESQRRDAERCALTAEISTLTSKLEEQEMKIVQMEEMKKDLSELQTKY 1177
1_pfamImport    1 ----RSGTNSTSMFENLQAQLKQREGEVQQLQWELSRRNAERDALNTEVSSLASKVEDLNSTVGQMETIKESLNDIQTKY 76  
EDW27078      385 GVHLSFMAGNTTTLEHLQSLLKQRDGELTHLQWELSRLQAERGVLDGEISHLTIELETMKEKMQSYETMEKCYEDLQHRY 464 
Q556B3        960 LNHSVGNGLLPASLEYLQSSLSQKEGEAMSLQAQVQSLNHSRKKLEDELVKLTTDNEELLSECKELKLQRQEIKDIQQRY 1039 Dictyostelium...
XP_004360565  776 QQQQQSSPHSTLSVEFYQSTLGHKEREIAMLNSKCLSFENSKKKLEEELIKLTTSNEQLLLESKELKNTKNEVKDIKQRY 855 
XP_020434692 1030 QQSQSGNTNSSLPMEFYNSNINQKDGEIAILQSKLQSSETLKKKLEEELIKLTTSNEQLLLESKEFKNIRSEINDMQKRY 1109
XP_002508205  712 AGSGGAELAVMRATEELQRQIRSKEVEITIVQDRVKQLEASERALSDELVRQT----QLMDEAGDPRQLRAELQELEGRH 787 
XP_002896721    3 dplsSNGNTSVLGLSQLQQRLRLREGENRMLKQQLEALEARQKQTTDEIVRLSTRNALLESGEAQREQTQLELAKLQKHQ 82  

XP_024326068  806 QTTLEMLGEKSEMVEELKADVQDVKAMYRELVENT 840 
XP_046444223  909 NALLQMYGEKIEENEELRLDLVDVKEMYKAQIDHL 943 
XP_002422748 1178 DALLEMYGEKVEEVEELRLDLQDVKEMYKTQVRDv 1212
1_pfamImport   77 DALLQMYGEKVEENQELRLDLEDVKEMYKTQIDQL 111 
EDW27078      465 DALLQMYGEKVERTEELELDLVELKSAYKLQIDEL 499 
Q556B3       1040 QTTLLMLGEKEEAVNELRLDIMDLKDLYKNQINEL 1074 Dictyostelium discoideum AX4
XP_004360565  856 GTVLELLGEKEEMVNELKLDIVDMKELYKSQISEL 890 
XP_020434692 1110 STALEMLGEKEEAVNELKMDIIDMKELYKTQINEL 1144
XP_002508205  788 IDALELMGETSEENEELKDRVQGLRMEVDRLTEQL 822 
XP_002896721   83 VVLLELFGEKEEQVEELQAEVSELKAFYRKQLDTL 117
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