Conserved Protein Domain Family
EVC2_like

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pfam12297: EVC2_like (This model is not part of the current CDD release)
Ellis van Creveld protein 2 like protein
This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.
Statistics
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PSSM-Id: 520188
Aligned: 10 rows
Threshold Bit Score: 611.372
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_030126588  221 GEHFAINYSALLDAEEMWHGRVLTLPVKLTFK-SSSQNKTHLVsltASLTITEEEKTKILYNHAISASAFFIAFF--ISL 297 
2_pfamImport    1 GDSYLVSYTASLDPGAISTLESLSLPAQLTFQ-SSMLNRTQLQ---AVLTITVAEKITVLPHHGLHAAGFFIGFL--LSL 74  
Q8K1G2        147 GECYSVSYTASLDPTALGTGESLDLPARLIFQ-SPSQNRTQLK---APFTITVEEKIMVLPNHGLHAAGFIAAFL--ISL 220  house mouse
Q86UK5        237 GDAFAVSYAATLQAGDLGNGESLKLPAQLTFQ-SSSRNRTQLK---VLFSITAEENVTVLPHHGLHAAGFFIAFL--LSL 310  human
XP_031799059  248 GDVYTVSYRARLTAKEAGDGKILSLPAQLTFQ-SPSLNKTQLK---ALLTVRGQEKAKVSPNHGAHAAGFFIAFL--VSL 321 
4_pfamImport    1 GSCYTVKYSAQMKGE---QNDILSLPAYLTFSnASQNDINLFGpvvANFTLRVNSTAKVSSNHGIHFVGFLVGFL--VAS 75  
1_pfamImport    1 GSQVVVNYTAHIRNH---KSEVMDLPAFVTFSnASQNDVSMFGpltANLTLR------IHPNHGVHLAGVVAGFFgtVFS 71  
XP_023181035  238 GSHVVVNYTAHVRSH---NNELLDLPAFLTFSnASQNDVSMFGplrANLTLRVNSTDRIYPNHGVHFAGFVAGFF--ITL 312 
XP_011473911  234 GSYVAVNYTAFVRSH---KSEILQLPAFLTFSnASQNDVCMFGplqANLTLRVNSTDAISPNHRVHFAGFAAGFL--VAS 308 
Q8MI28        137 GDSFSVSYTASLEARDVGSGDILLLPAQLSFQ-SSSPNRTQLK---APFTITAEEKITVLPNHGLHAAGFCVAFI--LSL 210  domestic cattle
XP_030126588  298 VLTCAVFFIIYRTQVLKWSFCsknqeiqpALSQNHKLEHSQFNSGELFSEDIIMNDQIIDILSFEEPGSMRQALEDLEVA 377 
2_pfamImport   75 VLSWVALFLLVHYRCLPGGLL--------ALYAENKLEPSPFASADGISEDLSLNDQMIDILTSEDPRSMLQALEELEIA 146 
Q8K1G2        221 LLTVAALFFLARGRCLQGGMLsrc----riqHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIA 296  house mouse
Q86UK5        311 VLTWAALFLMVRYQCLKGNMLtrh----rvwQYESKLEPLPFTSADGVNEDLSLNDQMIDILSSEDPGSMLQALEELEIA 386  human
XP_031799059  322 ALTCIIFLFMSQSRCFRWILCnknr-veqSPHQESKLEYSQFTFVDGVSEEFAISDQIIDILSAEEPGSMVQALEDMEIA 400 
4_pfamImport   76 ILMTLAFLLFSWIGIPQMSCCkrk--rrgGLSGDTDPEYAVCNVSETAKEEAAFEDKIVDIMILEDPQNMYQALENLDMS 153 
1_pfamImport   72 QLFYLFFIYFRYA-SRQCACIfl----qqRNRGDSEPEYAECNMSEAVKDEAAFEDKMVDTMVLEDPQNMYQALENLQMS 146 
XP_023181035  313 VLLLLGVLAIKFTSSRERFCLfq----rkRNRCHLDPEYADSSMSETIKDEAAFEDKMVDVMVLEDPQNMYQALDNLETS 388 
XP_011473911  309 ALLSVGFLAMNLAGPNAGLRLlq----qrRNRGDSDPEYADCSMREAIKDEATFEDNMVDVMVLEEPQNMYQALENVEMS 384 
Q8MI28        211 VLTWAVLFFMVRYQCVKGSSLtr----hqVQHHENKLEHSQFTSADGVNEDLALNDQMIDILSSEDPGSMLQALEELEIA 286  domestic cattle
XP_030126588  378 SLTRADADLEANRTQICKEVIAMMFKNMVLNHNLFPHVEKKISSVFRKQFLAMEEEiqeEYERKMVALTAECNLETR-KT 456 
2_pfamImport  147 TLNRADADLEACRTQISKDIIGFLLRSLTCGGHLSPQVERRDRFCFEKSSFLLEEC---DREDGWALTAEWWTWETRkED 223 
Q8K1G2        297 TLNQADADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEiqeEYERKMLALTAECDLEMR-KK 375  house mouse
Q86UK5        387 TLNRADADLEACRTQISKDIIALLLKNLTSSGHLSPQVERKMSAVFKKQFLLLENEiqeEYDRKMVALTAECDLETR-KK 465  human
XP_031799059  401 TLTRADADLQACRMQISKDIIGMLLKNLTLSGNLSPHMEKRMSSVFKKQFLMMETEvqeEYDRKMVALTAECTLEMR-KK 479 
4_pfamImport  154 TLLRAAASLESFRVQVYKDLVAMLLRNLKMNGGVSALAEKRLNSVLNGQLMGMEGKlkeEHVARMAALAAECNRETR-EE 232 
1_pfamImport  147 TLLHATNNLEATRIQIYRDVMSSLLGSLRSRGQASAQAQQRLLSVLHGQMLGMEGRlkeERGARMAALAGRCNQETR-EE 225 
XP_023181035  389 SLLQASSNLEATRIQIYKDLMSCLLGGLLSRGQISAQAQQRLLSVVHGQLLGMEGRlkeERGARMAALAGQCNLETH-EE 467 
XP_011473911  385 TLLRASSNLELIRIQIYKDVMSCLLGGLQSERRTSIRAQERLLSVLHGQLLAMEGRlkeDRGARMAALAGHCNLETR-EE 463 
Q8MI28        287 TLNRADSDLEACRTQISKDIIALLLKNLTSSGQLSPQVERRMGAVFKKQFLLLEKEiqeEYDRKMVALTAECDLETR-KK 365  domestic cattle
XP_030126588  457 MEAQCQKARAVNEEAEELMKKIneKPAIEYRSLLDKLHRLEQDCLKRFLFVKQEEYFAKAYRELAVTQRKELHTIFFTQI 536 
2_pfamImport  224 RKTSYQKENAACLSLTSCLFSL--QSAAECSSLLRTLHGLEQEHVWKSLALHQEEDFAQAHRQLAVFQRTELHGIFFAQI 301 
Q8K1G2        376 TENQYQREMVAMEEAEEVLKRVseRSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQI 455  house mouse
Q86UK5        466 MENQYQREMMAMEEAEELLKRAgeRSAVECSNLLRTLHGLEQEHLRKSLALQQEEDFAKAHRQLAVFQRNELHSIFFTQI 545  human
XP_031799059  480 TEAQCQREMAAMEEAEELLKHVseRSALEYRNLLHNLHRREQDHLRKSLLLKREEDFAKAYRELAIFQRNELHNIFFTQI 559 
4_pfamImport  233 MEAEHRRVTVEKAQAEHLFQQAdqQVVLELSVLLDKLHKLDQSYLQRCLLVRHEEASAKVQRQTVVCRRLELHKIFFEEL 312 
1_pfamImport  226 MEAEHRTEAAQKAQAELLCQHAnqQELLHCSVLLEKLHKLSQSRLQRILLVRHEEASGKVQRQIVEWRRVELHKIFSEEL 305 
XP_023181035  468 MEAEHQEQAAEKAEAERLRQHAdqQEFLQCSRLLEKLHKQRQSHLRRVLLVQREDASAKVQREIIEWRRVELHKIFSEEL 547 
XP_011473911  464 MEAEHRREAAEKARAERLCQHAdqQELLRCSVLLEKLHKLNQSRLQRTLLVRHEEASAKVQRQIVERRRVELHKIFSEEL 543 
Q8MI28        366 TESQYQREMAAMEEAEEVLKRVseRSAVECSSLLRTLHGLEQEHLRRSLALQQEEDLAKAHRQLAIFQRNELHNIFFTQI 445  domestic cattle
XP_030126588  537 INATSRGELKVEAAKTLVEGYSKIQGDIEDLMDFLQACKKYHLGKRFSYREYLISKIQSRDSHVSALINAAATQITSLIN 616 
2_pfamImport  302 KNAIFKGELKPEAAKTLLQDYSKLQEHMEELMDFFQATKRYHLSKRFGHREYLVQNLQSTETRVQGILNTAATQLTHLIQ 381 
Q8K1G2        456 QSAVSKGELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIH 535  house mouse
Q86UK5        546 KSAIFKGELKPEAAKMLLQNYSKIQENVEELMDFFQASKRYHLSKRFGHREYLVQNLQSSETRVQGLLSTAAAQLTHLIQ 625  human
XP_031799059  560 KSAVLKGDLKLETAKMLLQDYSKIQENIEELMDFLQANKKYHLSKRFGYTQYLIQSIQSLGTRDQSLLNTATAQIMSLIH 639 
4_pfamImport  313 EEATRMKELEKNVANQLLHAYFSSQDQLEEVLDIFLANQRSILEERHAQRQFLAHSLQSLKTLICEVFTNTSRQMENWFQ 392 
1_pfamImport  306 EEATRMGELEKSAAKSLQHDYFASQDQLEEVLDVVLANQRYVLAERHAQRKFLVHSLHSLNNLISDSFSSTSSNLDSWFT 385 
XP_023181035  548 EEATRMGELEKSTAKRLQHEYFTCQDQLEEVLDVVVANQRYVLTERSAQRKFLVHSLHSLEDLISETFSSASSNLDSWFS 627 
XP_011473911  544 EEAVRMDELEKSAAKSLLHKYFTCQDELEEVLDVVVANQRYVLSERSAQRRFLVHSLHSLNGLISDSFSTSSRTLDSWFA 623 
Q8MI28        446 KSAIFKGELKPEAAKMLLQDYSKIQESVEELMDFFQASKRYHLSKRFGHREYLVQNIQSSETRMQGLLSTASAQLTLLIQ 525  domestic cattle
XP_030126588  617 KTERAGHLPESHLGILLDRAEAEINFVKQKFDHDL 651 
2_pfamImport  382 KHERAGYLDEDQMEMLLERVQMEVFSVKQKLDNDL 416 
Q8K1G2        536 KHERAGYLDEDQMETLLERAQTETFSIKQKLDNDL 570  house mouse
Q86UK5        626 KHERAGYLDEDQMEMLLERAQTEVFSIKQKLDNDL 660  human
XP_031799059  640 KNERAGYLDEDQMETLLARAQAEVLSVQQKLENDL 674 
4_pfamImport  393 DLKNERYVTEEQANLLLDKAKKELLHVKQNLDEGL 427 
1_pfamImport  386 HIRRGGSVPSEQLDQLQDKAQKELVMVRQRLEEAL 420 
XP_023181035  628 HIKSGSAVPSEQLDQLQEKAQKDLVMVRQRLDETL 662 
XP_011473911  624 HVRRGSLIPAEHIEPLQEKAQKELVMVRQRLDETL 658 
Q8MI28        526 KHERAGYLDEDQMQVLLERAQTEVFSIKQKLDNDL 560  domestic cattle
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