7MUD


Conserved Protein Domain Family
T4BSS_DotH_IcmK
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pfam12293: T4BSS_DotH_IcmK (This model is not part of the current CDD release)
Putative outer membrane core complex of type IVb secretion
T4BSS_DotH_IcmK is a family of bacterial transporter proteins from Proteobacteria. DotH is an integral outer membrane component and it may form an outer membrane complex along with DotD and DotC functionally equivalent to secretins. DotH is the strongest candidate for the VirB9 counterpart of other T4BSS systems.
Links
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Statistics
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PSSM-Id: 520185
Aligned: 7 rows
Threshold Bit Score: 313.994
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7MUD_AH      121 PLNPEQVVKLKQIYETSEYAKAATPGTPPKPTATSQFVNLSPGSTPPVIRLSQGFVSSLVFLDSTGAPWPIAAYDLGDPS 200 Legionella pneu...
Q5ZYC2       121 PLNPEQVVKLKQIYETSEYAKAATPGTPPKPTATSQFVNLSPGSTPPVIRLSQGFVSSLVFLDSTGAPWPIAAYDLGDPS 200 Legionella pneu...
Q83B85       106 PLSPDQIRTLHYLFDQSQQAAAAAPGVPPKPTSASVIVNLSPGATPPIIRLSSGFVTSLVFLDSSGAPWPIQAYDLGDPK 185 Coxiella burnetii
WP_014103953 129 PMRPEEIRELLKRYDQTLEAVQTPLQPYPEPEVVVQTVALDPGVRPSEIKVAVGHVTTLNFVDVTGAPWPIEDVSWAG-- 206 Micavibrio aeru...
Q877T8       105 PLTPQEIRQLRGQVGEVDKA-MAAPQVAIVPRISAQTVNLSPGASLPLVRTAVNYPTSLTFIDSTGAPWNLGAAPISGNP 183 Pseudomonas syr...
WP_014448760 142 PLSPGDIGLLKGILKQTQKAVHGPP---PEGRAVSVSVSLDPGAQFPVIHLVPGIASTITVVDASGAPWPIEDVIVGNAK 218 Leptospirillum ...
WP_012383005  53 PLTPEMIRELGRRYREIKREEERATTQIATPVSRRINVAFIPGQATNIIQTVKGYPSAISFFDSTGQPWPIEWNSNSNPS 132 Beijerinckia in...

7MUD_AH      201 ----------------------SFNIQWDKTSNTLM-IQATKLYNYGNLAVRLRGLNTPVMLTLIPGQK-------AVDY 250 Legionella pneu...
Q5ZYC2       201 ----------------------SFNIQWDKTSNTLM-IQATKLYNYGNLAVRLRGLNTPVMLTLIPGQK-------AVDY 250 Legionella pneu...
Q83B85       186 ----------------------SFNIQWNKKDNTLL-VQALSHYKAGNLAVVLEGLDTPVMLTLMPGQR-------AVDY 235 Coxiella burnetii
WP_014103953 207 ----------------------DFEILKPGEGGWVLrVTPMQEFAYGNLSVKLLELKTPITFVMNTRRD-------TVHY 257 Micavibrio aeru...
Q877T8       184 ----------------------DITPYYVPNSPVMV-LYAAKPFASGNVTVYLKGLAVPIMLYVSSGESdtkaqtwAVDA 240 Pseudomonas syr...
WP_014448760 219 ----------------------SFPVRRMSATNGVV-IEPQNNVGWTSLSLVLRGRGTPAVLKLVDSDT-------LSDT 268 Leptospirillum ...
WP_012383005 133 siaggsncnattntggpavaavGFHVCTPTKGSNVLeVTPMSLEPRGGLVVTLEGAPKPLSFMLVGGGG-------RYDS 205 Beijerinckia in...

7MUD_AH      251 RVDLRVQGYGPNAK-SMPTEEGIP-PSANDLLLHVLEGVPPPGSRRLVVSGG---DARAWLSNEKMYVRTNLTILSPGWL 325 Legionella pneu...
Q5ZYC2       251 RVDLRVQGYGPNAK-SMPTEEGIP-PSANDLLLHVLEGVPPPGSRRLVVSGG---DARAWLSNEKMYVRTNLTILSPGWL 325 Legionella pneu...
Q83B85       236 RVDLRVPGLGPNAN---PDLDGLP-ATESPELLNVLNGVPPSNSKPLTITGG---DCQGWLIKGHIFLRTRLTVLSPGWI 308 Coxiella burnetii
WP_014103953 258 RMDARIPEYGPYAK-PPIIDGGITiAAGNAAQASILDGIIPDSAEKLVVSGVd-gRTTAYRFKGNVYVRTPLTMLSPGWS 335 Micavibrio aeru...
Q877T8       241 RLDLRVPRRGPGAQ-PGAAPEVRI-GLHDRVLQGFLDGVPPKEAKQLKTTGNv-pDTTVWQMGDDLYIRTRADIRDE-FE 316 Pseudomonas syr...
WP_014448760 269 RVTARIEARGPNAV-IPIFREAKP-VVSSRVL-AFLDGIPPSEARAIPVHGTg--DMEAWRDGNRLFVRTHLDVLAPAWI 343 Leptospirillum ...
WP_012383005 206 DVSVHVADRGPHAKvEITRRTPAP-DTGSGFLTAMLDGVPPAEATPLVVSGVspeDLRAWRLGDKVFLRTRMTLISPEWT 284 Beijerinckia in...

7MUD_AH      326 ASMTSADGTHAYEMQKSPVLLVSWHGKVMQ 355 Legionella pneumophila
Q5ZYC2       326 ASMTSADGTHAYEMQKSPVLLVSWHGKVMQ 355 Legionella pneumophila subsp. pneumophila str. Philadelphia 1
Q83B85       309 STMSSADGTHAYELQTTPVVLASQRGQLVK 338 Coxiella burnetii
WP_014103953 336 GSVSSADGMNVYTIEDAPVLLLSDKGRMVR 365 Micavibrio aeruginosavorus
Q877T8       317 STLSSADGTHLWKLPVTPYVSFSVMGHTAA 346 Pseudomonas syringae pv. tomato
WP_014448760 344 ETVSGPNGMKLYVF--SPVSVITAAGEDGE 371 Leptospirillum ferrooxidans
WP_012383005 285 ASEAGEGGLTIYSVPATPVVLLSGHGRTVS 314 Beijerinckia indica
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