Conserved Protein Domain Family
Caprin-1_C

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pfam12287: Caprin-1_C 
Cytoplasmic activation/proliferation-associated protein-1 C term
This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteristic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.
Statistics
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PSSM-Id: 403488
View PSSM: pfam12287
Aligned: 28 rows
Threshold Bit Score: 310.584
Threshold Setting Gi: 0
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015193585 323 VQDLMAQMQGPYNFMQDSMLEFDGQAidPAIVSAQPmkPAQSMeMPQMvcp-------pvHAESRLTQPNTVPVQPEATQ 395 spotted gar
NP_001003484 340 VQDLMAQMQGTFNFMQDSMLEFEGPPldPAIVSAQPmkPA------QMvc----------ppESRLPQHNALSVQPEPTQ 403 zebrafish
1_pfamImport   1 VQDLMAQLQGTYNFMQDSMLEFDGQAldPAIVSAQPmkPV------QMcgpsiffpsqtaHPESRLLPTCAVSGPPESSP 74 
XP_011487811 341 VQDLMAQMQGTYNFMQDSMLEFDGQAldPAIVSAQPmkLVQTVdLQQLsgp-------liRSESRLSQTSTVSg------ 407 Japanese medaka
XP_021323301 357 VQDLMAQMQGPYNFMQDSMLDFDGQSldPAIVSAQPmkPV-SMeMPPMvcq-------paHPETHLAQPPAVGVQPEPTQ 428 zebrafish
XP_022520086 357 VQDLMAQMQGPYNFMQDSMLEFDAQSldPAVVSAQPmnPVKSMeVPQMvcp-------saHPQSHLAQPLTVPVQTESTQ 429 Mexican tetra
XP_015290416 365 VQDLMAQMQGPYNFIQDSMLDFENQTldPAIVSAQPmnPTQNMdMPQLvcp-------pvHSESRLAQPNQVPVQPEATQ 437 crab-eating mac...
XP_023811474 366 VQDLMAQMQGPYNFMQDSMLEYDGQPidPAIVSAQPmkPAQNMeAPQMvcp-------pvHPESRLSQSNSVPVQPEPTQ 438 Japanese medaka
XP_003442433 339 VQDLMAQMQGTYNFMQDSMLEFDGQAldPAIVSAQPmkPVQAVdLQQMggp-------llHSESRLPQTAAVSGPQESSQ 411 Nile tilapia
XP_022525820 374 VQDLMAQMQGTYNFMQDSMLEFDGPPldPAIVSAQPmkSA------QMvca-------paHTENRLPQHSTVTVHPEPTQ 440 Mexican tetra
XP_015193585 396 vPLVSPTPEAFSATPPLYQpSHTTDPrpqTENIDPiQASISLTSEQPPASSALPAVsqpqvFQavpSKPLHSSGINVNAA 475 spotted gar
NP_001003484 404 vPMVS------ASTPPLYQpAHTSEPrpqTDTIDPlQVSMPLPSEQPPT-----PSsqpqvFQ---PKPLHS-GINVNAA 468 zebrafish
1_pfamImport  75 vSGVEAQQEN-SRFP-------------------PpQVSMSLSSEPSPTQCPLSSA-----FPp-vSKSTHTGGINVNAA 128
XP_011487811 408 -----------------------------PRESSP--ASLSLPSEPSPASCSLSPA-----FPp-vSKPTLTGGTNVNAA 450 Japanese medaka
XP_021323301 429 iPMVSPSPETFSTPPPMYQsPHTADPrpqTGSIDPiQASMPL-TEQTPSSATLPPAsqtqvI----PKPLHSSGINVNAA 503 zebrafish
XP_022520086 430 vSIVSPSPEAYSSPPPSYQtSHTADPrprADSEDPiHVPISL-TEHPPSSTALAGTsqpqvFQp-sSKPLCNSGINVNAA 507 Mexican tetra
XP_015290416 438 vPLVSSTSEGYTASQPLYQpSHATEQrpqKEPIDQiQATISLNTDQTTASSSLPAAsqpqvFQagtSKPLHSSGINVNAA 517 crab-eating mac...
XP_023811474 439 vPIVSPTP------PPMYQsSHAQEPrlsPEVIDPiQTSMSLSTEQPPPSTALAPAsqaqgFPa-vSKPPHSSGINVNAA 511 Japanese medaka
XP_003442433 412 -------------------------------------ASMSLSSEPSPAPCSLSSA-----FPp-vSKPTLTGGINVNAA 448 Nile tilapia
XP_022525820 441 vPMVSPPAEAYTSTPPLYQpPHSSEPrpsADSIDPlQVSMPLSSELPPA-----PSsqpqvFQs-vSKPLHS-GINVNAA 513 Mexican tetra
XP_015193585 476 PFQSMQTVFNLNAPVPPANEt--EALKQpSQYQTSYSQSFSSQTQHQVEQPELQQEQLQSVVGAFHt-QDQTIPTTAGHq 552 spotted gar
NP_001003484 469 PFQSMQAVFNMNAPVPPTNEm--DSPKIsSQYQSSYGQGFSTQAALPAEQQEMPQEALQSV-GSFQs-QDQGITSAGGHq 544 zebrafish
1_pfamImport 129 PFQSVQAVFNLNAPVPPATDgqaDPLKQpGQFPGGYGQGFSSQSESTVDQPDIPQETLQSVVGGFQp-PDHVMPSAGSH- 206
XP_011487811 451 PFQSVQAVFNMNAPVPPASEgveDPLKQsSQFAGGYRAGFHSQTENASEQPDLPKERLQSVVGGFSp-QDQVISSQGGH- 528 Japanese medaka
XP_021323301 504 PFQSMQTVFNLNAPVPPANDt--DSIKQaSQYQNSYSQGFNSQTQLPVEQTDLPPEQLQAVVGAFHs-QDQSLQNSAAHq 580 zebrafish
XP_022520086 508 PFQSMQTVFNLNAPVPPSNEt--ESPNHsSQYQNCYSQGFSSQTKHSSEQADMQSEQHQSVVGSFQ---EQSLNSCAGHp 582 Mexican tetra
XP_015290416 518 PFQSMQTVFNMNAPVPPVNEp--ETLKQqNQYQASYNQSFSSQP-HQVEQTELQQEQLQTVVGTYHgsPDQSHQVTGNH- 593 crab-eating mac...
XP_023811474 512 PFQSMQTVFNLNAPVPPANEa--EALNHaNQYQNSYNQAFSSQPQHPAEPAEMPSEQLQSV-GAFHs-QDP----SAGH- 582 Japanese medaka
XP_003442433 449 PFQSVQAVFNMNAPVPPTTDgqvDPLKQpSQFPGGYGQGFSSQPENTVDQPDIPQERLQTVVNAFQp-QDQIMSSTAGH- 526 Nile tilapia
XP_022525820 514 PFQSMQAVFNLNAPVPPSNEm--DSQKMsNQYQSSYTPSFSSQSPHSVEQQELQQEPLQSVVGAFHs-QDQGIPSSGGHq 590 Mexican tetra
XP_015193585 553 qLSQQPPq-QGSGFARPGQSFYNSRAMSRGGPRNSRGMINGYRGPsNGFRgGYEGYRPsFSNT-PNSGYGQSQFSTpRDY 630 spotted gar
NP_001003484 545 sAPQQPSg-QGTGFGRPGQSFYSNRAMPRTGPRNPRGSLNGYRGPsNGFRgGYDGYRApFPNT-PNTGYGQTQFSTpRDY 622 zebrafish
1_pfamImport 207 ---EESP--PAAALAQSGQSFYNSRAVPRGAARSGRGMMNGYRGS-NGFRgGYEGYRPpFSNA-PSSGYGQTQFNTsRDY 279
XP_011487811 529 ---EDSS--AGGGFGQSSQSFYNSRAAPRGGPRNARGMMNGFRGSsNAFKgGFEGYRPpFSNTpPSSSYGPAQFNTnRDY 603 Japanese medaka
XP_021323301 581 vMSQQQAgvQGNGFGRQAQSFYNSRGMSRGGPRNSRGIINGYRGPsNGFRgGYEGYRPpFSNS-ANPGYGQTQFSTpRDY 659 zebrafish
XP_022520086 583 iLSQQPVg-PGATFNRQPQSFYNSRGVSRGGPRNSRGVINGYRGPsNSFRgGYDGYRPpFSGT-PNSGYGQVQFGAaRDY 660 Mexican tetra
XP_015290416 594 ---QQPPq-QNTGFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPaNGFRgGYDGYRPsFSNT-PNSGYTQSQFSApRDY 668 crab-eating mac...
XP_023811474 583 ---QQPVq-QGPGFGRQTQSFYNSRGMPRGGPRNARGLINGYRGSsNGFRgGYDGYRPpFNNS-PNSGYGQTQFSTpRDY 657 Japanese medaka
XP_003442433 527 ---EDPS--VGAGFGQSGQSFYSSRAVPRGGPRNARGVMNGYRGSsNGFRgGYDGYRPpFSNA-PSSGYGQAQFNTsRDY 600 Nile tilapia
XP_022525820 591 sMPQQASg-QGTGFSRQTQSFYSSRAVPRAGPRNARGAMNGYRGPsNGFRgGYDGYRPpFPNT-PNTGYGQTQFSTpRDY 668 Mexican tetra
XP_015193585 631 SNSSYQRDGYQQNYKRGAGP-GPRG 654 spotted gar
NP_001003484 623 SNNTYQREGYQQSFKRGAAQ-GPRG 646 zebrafish
1_pfamImport 280 SNNTYQREGYQQNYKRGPAQ-GPRS 303
XP_011487811 604 SSSSYQREGYQQGYKRGVTQ-GPRG 627 Japanese medaka
XP_021323301 660 SGSNYQRDGYQPNYKRGSGQ-GTRG 683 zebrafish
XP_022520086 661 SNTSYQRDGFQQNYKRPAGP-GPRG 684 Mexican tetra
XP_015290416 669 SG--YQRDGYQQNFKRGSGQsGPRG 691 crab-eating macaque
XP_023811474 658 SNGNYQRDGYQQNYKRGTGQ-GPRG 681 Japanese medaka
XP_003442433 601 SSSSYQREGYQQGYKRGAAQ-GSRG 624 Nile tilapia
XP_022525820 669 SSSTYQRDGYQQSFKRGAAQ-GPRG 692 Mexican tetra
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