Conserved Protein Domain Family
RCR

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pfam12273: RCR (492500 is an unknown moldel)
Chitin synthesis regulation, resistance to Congo red
RCR proteins are ER membrane proteins that regulate chitin deposition in fungal cell walls. Although chitin, a linear polymer of beta-1,4-linked N-acetylglucosamine, constitutes only 2% of the cell wall it plays a vital role in the overall protection of the cell wall against stress, noxious chemicals and osmotic pressure changes. Congo red is a cell wall-disrupting benzidine-type dye extensively used in many cell wall mutant studies that specifically targets chitin in yeast cells and inhibits growth. RCR proteins render the yeasts resistant to Congo red by diminishing the content of chitin in the cell wall. RCR proteins are probably regulating chitin synthase III interact directly with ubiquitin ligase Rsp5, and the VPEY motif is necessary for this, via interaction with the WW domains of Rsp5.
Statistics
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PSSM-Id: 492500
Aligned: 48 rows
Threshold Bit Score: 31.592
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013949909  36 RWVLAGIAIICALVLLFFCLC-ISRRNRR----------------------RGAQPMYGTGWFsgppaApagrpsgsnky 92 
ESK94168      43 rvvaGVIIAMVILLSVISCFIySAKRRRMaamiqmqrqnaaayqayqynrpSGYDVNQSQGWAgpppqG----------- 111
XP_009159897  45 KWAVIATILAALALYLVGGYL-HAKRRMR----------------------KGLPPLAYHRWLvsrrqRmafahqhpqya 101
CCE35144      29 RWVIFFLLLSLVLLYVVGGTL-HAKKRIR----------------------NGQEPLAYHRFLvkrhfReppanqqwpng 85 
XP_008088298  37 RWSVFFGILFLFLGYMVGGYW-HAKKRIN----------------------KGLKPLAYHRWLlnrqqRarydpayqnps 93 
XP_001593081  44 RWSIFWGLFLLFMLWIIVGYW-HAKRRLR----------------------KGLKPLAYHRWMlnrrqRaqydpayqnpd 100
CCD46611      44 RWSVFWGLFFIFMIWIIGGYW-HAKRRLR----------------------KGLKPLAYHRWMlnrrqRaqydpayqtpn 100
2_pfamImport   1 -WSVFLGLTTLFAAFLIIGYM-HGKRRLK----------------------KGLLPLGYHRWLfsraqLarvdsryawpq 56 
XP_001647157  34 RWILFALFGLALIVFLISTLL-INRRRSQ----------------------TGRAPIRGTAWL----------------- 73 
XP_003686712  42 RWILFVIFVVFLLVIFLGTIR-ANKRRRT----------------------LGQAPIRGTAWM----------------- 81 
XP_013949909  93 nsnnnayemnny---qsgynqggysqqqppygegygyTSPPPYGQGPV----------PNqttGTT---FN-AN------ 149
ESK94168     112 -------------------------------------PPPPGYTPAPYpgqqayypqgGS---------FS-PPdppeyg 144
XP_009159897 102 nqfsfyrnqntpygygqgrhtpygygqgqaypmgaygPPPPAYGE------------------PDYvpaYT-PP------ 156
CCE35144      86 qqqgyyyf-----------qqqpqqsgfqqpaypmndMPLPAYDPN-------------------RppvYSgPP------ 129
XP_008088298  94 ayyh-------------------qyppqqygmqpyggAPPPVYDPN-----------------SAMpptYQ-PP------ 130
XP_001593081 101 vyyn-------------------qfptaaggqygmhpMPPPMYDPN-----------------APMpptYQ-PP------ 137
CCD46611     101 vyy--------------------nqfppaggqygmhpMPPPMYDPN-----------------APLpptYQ-PP------ 136
2_pfamImport  57 atynny---------------rpeyyqqqqgyygmqgMPPPTYDPN-----------------AARppmYA-PP------ 97 
XP_001647157  74 --------------------------------------TPPTYRQSQReyngn-----sgrvvEDFvptYT-EKant--e 107
XP_003686712  82 --------------------------------------TPPTYRQSERdynangsaanG----HDFvpkYT-AEand--q 116
XP_013949909 150 -DGYmtgqpqYG-------------VQQPQ-------HAYQP------------DGHYQPPAGPPP 182
ESK94168     145 kTGY------DG-------------YPAPAgtpsggiQSYTMpdsp----gnrqNVSYQPPAGPPP 187
XP_009159897 157 -AGN---------------------KVDPD-------QN------------------YAPPSGPPP 175
CCE35144     130 -EGG------SK--------------VDPS-------QNRAPtqraq---esneAPEYAPPQGPPP 164
XP_008088298 131 -VGA------TK--------------VDPT-------QWRAeptrrp-aesgeaAPDYSPPPGPPP 167
XP_001593081 138 -AGA------TK--------------VDPS-------QWGSqptrrpaddggesAPDYEAPPGPPP 175
CCD46611     137 -AGA------TK--------------VDPS-------QWRSeptrrpaddggesAPDYEAPSGPPP 174
2_pfamImport  98 -DGG------SK--------------VDPS-------QEYG----------------ITPPPGPPP 119
XP_001647157 108 dLGH------FNqrgefipneeaeyVAPPV-------LDSEMnrq-------pmNGHDQSIPVPPP 153
XP_003686712 117 dLGY------YDargefhpnskseyLPPPP-------LVHEVdsna-----sttSNSHERPNIPPP 164
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