Conserved Protein Domain Family
zf-CpG_bind_C

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pfam12269: zf-CpG_bind_C 
CpG binding protein zinc finger C terminal domain
This domain family is found in eukaryotes, and is approximately 240 amino acids in length. This domain is the zinc finger domain of a CpG binding DNA methyltransferase protein. It contains a CxxC motif which forms the zinc finger and binds to DNA.
Statistics
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PSSM-Id: 403474
View PSSM: pfam12269
Aligned: 23 rows
Threshold Bit Score: 271.856
Threshold Setting Gi: 341892627
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EGT48562     135 LRLVEHLPKRVAEHFGDgPAgp-rTLEAEIIEKQVKVREEFKQTTEKESVLIAFLQKLDTFVANQVDLkPLGTEE----- 208 Caenorhabditis ...
XP_002405094 169 NRIYELVPHRIQQWQSS-SC----HADETSRRQLEQIRKQQLDARNTLQLLEARRTQLEALIERAKQT-PLIEDEeta-- 240 black-legged tick
XP_025017496 209 NRIIEILPERIRFWQST-SS----SADVFSNRELDAIRTEGETAKRLLEELDGKQKELEAMIAEAKKL-PPISEDev--- 279 two-spotted spi...
Q86D13        69 MRLTEILPNRCKQYFFEgPSggprSLEDEIKPKRAKINREVQKLTESEKNMMAFLNKLVEFIKTQLKLqPLGTEE----- 143 Caenorhabditis ...
EDV24137     279 ERILRVLPNKIKTLRTQ-GL----TADIQGELKIKELERKRKIAEKRLAELDEMSAKLDHFVNWTKMS-SASLEPdan-e 351 Trichoplax adha...
XP_001624861 281 RRIQEILPKRMKQWNRE-PC----EADERANEALQKVLKKKQEAQDMLLELDRMSQALESIIQKGEKL-TAIPEEsqe-a 353 starlet sea ane...
NP_001071905 141 NRLLQILPQRIQEWNGT-PT----VANDNGRQELDRIRKRMINARTELQALEQKFHRLETIISTGRSL-TVVEKLdnd-d 213 vase tunicate
1_pfamImport   3 SRIYEILPRRIQEWQRS-PC----VAEEWEKKLLKEIRKEQREAWLHVRDAERRFQELEDVILQAKRQ-VVQENGennnk 76 
NP_001073166 406 NRIYEILPQRIQQWQQS-PC----IAEEHGKKLLERIRREQQSARTRLQEMERRFHELEAIILRAKQQ-AVREDEenn-e 478 Norway rat
EKC23875     311 SRIYELLPPKIQQWQSS-PC----VTEENNNKMLEKIRREQLECRQKLAQLDLKHQELDGVIERAKNV-SIAPEQdek-- 382 Pacific oyster
EGT48562     209 --RLDDTVSYACLICANnDIPLSKYVKHIELCWARSERAMSFGAPEKNNDK-----IYCEYKEEKTGSYCKRLKSLCPEH 281 Caenorhabditis ...
XP_002405094 241 ddYEESELSTYCVTCGH-EVSARSAMRHMEKCFNKYESQSSYGSIYKTRIEgd--nVFCDFYNPHQKTYCKRLRILCPEH 317 black-legged tick
XP_025017496 280 deETGDELMTYCVTCGH-EVASRTALRHMERCFNKFESQISFGGVYKTKVEg----VFCDVFNPHQKTYCMRLKVLCPEH 354 two-spotted spi...
Q86D13       144 --RYDDNLYEGCIVCGLpDIPLLKYTKHIELCWARSEKAISFGAPEKNNDM-----FYCEKYDSRTNSFCKRLKSLCPEH 216 Caenorhabditis ...
EDV24137     352 dgNEDTDLQIYCVTCGH-SIPPRNAIKHMEKCYIKEESLTSYGSKYATNVGpnevsLFCDEYNAQQGTYCKRLRVLCAEH 430 Trichoplax adha...
XP_001624861 354 dmDTDTDLQIHCVTCGL-LLAPRVALRHMEKCYMKNESLTMFGSAYKSAGT-----LFCDYFNAQQGIYCKRLRVLCPEH 427 starlet sea ane...
NP_001071905 214 esEGEMDQSIYCVVCGH-SVSIRNAIKHMDKCYIKIESQMSFGSVYPTRIEgs-qrLFCDVYNEQQQTYCKRLQVLCPEH 291 vase tunicate
1_pfamImport  77 rySKHSEHQIFCVSCGH-SVNSQVALRHMERCYAKYESQMIFGSLEPTRIEgv-srLFCQVYSPQSKTYCKRLKVLCPEH 154
NP_001073166 479 ndSDDTDLQIFCVSCGH-PINPRVALRHMERCYAKYESQTSFGSMYPTRIEga-trLFCDVYNPQSKTYCKRLQVLCPEH 556 Norway rat
EKC23875     383 dnEDDLELSLYCVTCGA-ELNQKGALRHMEKCFSKFEAQTSFGSIYKTRIEgn--sMFCDYYNAQQKVYCKRLKVLCPEH 459 Pacific oyster
EGT48562     282 RKPGVEQHLMVCGYPKkwidmfgtsTYtGTFselialeDPFGDEgCRTLKEVCSMHLKWIPSIRGCIELEQAGLFQRLFD 361 Caenorhabditis ...
XP_002405094 318 SKEPKVNDDEVCGFPL---------VS-NVF-------DHSGDF-CNLPKKRCSKHYCWDKFRRAEIDMEIVRQWLRLDE 379 black-legged tick
XP_025017496 355 TKEQKIPDNEVCGYPL---------VT-NCF-------ELTGTY-CRLPKKKCMRHYCWEKLRRAEIDMEKVQKWLKLEE 416 two-spotted spi...
Q86D13       217 RKLGDEQHLKVCGYPKkwed-gmieTA-KTVseliemeDPFGEEgCRTKKDACHKHHKWIPSLRGTIELEQACLFQKMYE 294 Caenorhabditis ...
EDV24137     431 TKEPKIPANEVCGCPL---------TR-NVF-------EETDDF-CRVRKRSCIKHYRWERLQRANIDRERIQQCLLIEE 492 Trichoplax adha...
XP_001624861 428 TKEPKIPQTAVCGCPL---------VT-NVF-------EETDKI-CSAPKRTCMKHYRWDKLRRAEIDLQRVQQWIKLEE 489 starlet sea ane...
NP_001071905 292 TKEPKVPETEVCGCPL---------TC-DIYgte--lpTKPNHF-CRAAKRKCTRHFKWETMYRAEVDLQRIRQWLKIDE 358 vase tunicate
1_pfamImport 155 SREPKAPADEVCGCPL---------VR-NVF-------ELTGDF-CRLPKRQCNQHYCWEKLHRAEVDLEQLRAWGKLQM 216
NP_001073166 557 SRDPKVPADEVCGCPL---------VR-DVF-------ELTGDF-CRLPKRQCNRHYCWEKLRRAEVDLERVRVWYKLDE 618 Norway rat
EKC23875     460 TKEPKVGPEEVCGCPL---------VI-HVF-------QETGEI-CRVPKKKCNKHYCWEKLRRAEIDLERVRQWLKLDD 521 Pacific oyster
EGT48562     362 LVTENSRLQDRLEWNSNALSIM 383 Caenorhabditis brenneri
XP_002405094 380 LYEQERSTCTSMTSRGGVLGLM 401 black-legged tick
XP_025017496 417 LFEKEQKIRYTLQNRGAVLGLL 438 two-spotted spider mite
Q86D13       295 LCHEMHKLNAHAEWTTNALSIM 316 Caenorhabditis elegans
EDV24137     493 TYEQIRIIQTAKEGRRGLLGIM 514 Trichoplax adhaerens
XP_001624861 490 AFEQERAITHTSAQRGGVLGLL 511 starlet sea anemone
NP_001071905 359 IFDEERRIKTAMSNRAGLVSLL 380 vase tunicate
1_pfamImport 217 LWKQERNIQMAKANRAGLLALM 238
NP_001073166 619 LFEQERNVRTAMTNRAGLLALM 640 Norway rat
EKC23875     522 LFEQERNIRVSMANRVGVLGLM 543 Pacific oyster
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