4XYH


Conserved Protein Domain Family
CAF1C_H4-bd

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pfam12265: CAF1C_H4-bd (This model is not part of the current CDD release)
Histone-binding protein RBBP4 or subunit C of CAF1 complex
The CAF-1 complex is a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically it facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). This domain is an alpha helix which sits just upstream of the WD40 seven-bladed beta-propeller in the human RbAp46 protein. RbAp46 folds into the beta-propeller and binds histone H4 in a groove formed between this N-terminal helix and an extended loop inserted into blade six.
Statistics
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PSSM-Id: 520172
Aligned: 222 rows
Threshold Bit Score: 37.5624
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4XYH_A        28 EEYKLWKQNVpflYDLVITEALEWPSLTVEW-----------FPGSersladnssiqkLLL-GTQTSgNDQNYLQVASVQ 95  Schizosaccharom...
XP_002500380  29 DEELEYDPSV---YDCLHAWQLDWPCLSFDIlrdelgdtrerFPHSl-----------FAIaGTQADvATKNHLTMMRLT 94 
XP_003059108 133 DEELEYDPTA---YDCLHAWQLEWPCLSFDVmpddlgddrrhFPHAl-----------FAVaGTQASkAHQNNLTLMRVT 198
Q5CQT9        87 NQELVYEPKA---YKMYHKCLVEWSCLTLDIlpdklgdnrtqFPHTc-----------YVVaGTQANmEDNNHILLMKWS 152 Cryptosporidium...
XP_002182244  93 GQKLEMDPAA---YKMHHALTPEWPSLTFDFlrddrgeartrFPHSl-----------LAAvGTQADrPENNQLTIMKLS 158
CBN76255     140 GDELEYDSTA---YHMYHSLRPEWPCLSFDVirdslganrsrYPHTv-----------FAVaGTQADrADNNRLQVMKLS 205
XP_020435279  76 DEELIYDSSA---YDMMHTMTVEWPCLSFQPlrdnlglnrskYPHTm-----------YMVaGTQADqAKNNKILVMKVS 141
Q54ED4        82 DEVLDYDSTA---YDMMHSMSVEWPCLSFHPikdelgaqrnkYPHTm-----------YLVaGTQADeAKNNKVIIMKAK 147 Dictyostelium d...
XP_004367169  85 DEYLTYDSTA---YDMMHSMTVEWPCLSFQPlkdtlgnqrnkYPHTm-----------YMVaGTQADqAKNNRILVMKIS 150
XP_002902551  92 DEVLDYDSSA---YDMYYAMTAEWPALSIDVvrdnlgavrsrFPMTv-----------FMVaGTQATnADDNQITVMKMS 157 Phytophthora in...
4XYH_A        96 LPT 98  Schizosaccharomyces japonicus yFS275
XP_002500380  95 RLK 97 
XP_003059108 199 QLR 201
Q5CQT9       153 RMH 155 Cryptosporidium parvum
XP_002182244 159 DLS 161
CBN76255     206 DLH 208
XP_020435279 142 SLC 144
Q54ED4       148 QLH 150 Dictyostelium discoideum
XP_004367169 151 ELH 153
XP_002902551 158 ELH 160 Phytophthora infestans T30-4
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