Conserved Protein Domain Family
PIP49_C

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pfam12260: PIP49_C (This model is not part of the current CDD release)
Protein-kinase domain of FAM69
This is the C-terminal region of a family of FAM69 proteins from Metazoa and Viridiplantae that are active protein-kinases. The family members have a short transmembrane helix close to the N-terminus, and thereafter are highly enriched with cysteines. FAM69 proteins are localised to the endoplasmic reticulum. Many members also have a short EF-hand, calcium-binding, domain just upstream of the kinase domain. The exact function of the more N-terminal family is uncertain.
Statistics
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PSSM-Id: 520169
Aligned: 22 rows
Threshold Bit Score: 143.222
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q1RLQ5       194 AWALLQLN-EVLLAVVLQG-RE--HTPKLLGFCGDLYVVERVPHAPLFGItlpwpmdlwipagMRRSMDQWFTPSWPRKA 269 zebrafish
XP_002434016 187 AYTASVNP-EPLILQAFPR-RDgwPFPEFRGSCGRL-VVESYEGTPL---------------------SQFELLDWSVRA 242
XP_002432435  62 LWSFLDVSiEPLLMLSLGK--S--GFPKYIGACGDFLVEEYKG-L---------------------PLDNFLSCDFKTRA 115
XP_419100    179 MWSLLQQE-EYIFFSLLQD-FSk-HVLRIIGSCGHFYAVEYLTAGHAWHKtlfp------lenIVGPSLAGRRSRVKAII 249
1_pfamImport   1 LWALLQQE-EFVLLSLLRG-RSp-HAPPVLGSCGHFYAVEHLAAGSPGHRal----------fPLGP-DGGRRGQARAVS 66 
Q8BQT2       184 AWSLLQQE-EYVYFSLLPDlSR--HILPVLGSCGHFYAVEYLAAGSPHHKal---------fpLDDA------GQAQAIS 245 house mouse
XP_011253757 178 LWPLLEEN-EYLMMILYED-RD--VFPQLIGTCGTFYAVEYVRPIETPTTv-----------lALSD----SKPEWAKRL 238
EFX70491     179 LWQLSQDN-EYVTLMINQH-SH--LFPKILSSCGTFYAVEYAKPISRLNI-------------YSDR-----PEDFYARI 236
XP_002009125 167 FWRLFKDN-NYMMGKLFDE-DS--VFPAVLGSCGPYYATEGLEIVQANPS-------------IIQY----LSSNRQQRL 225
XP_036760196 206 LLTLAFNP-EPLVLQSFPS-DEgwPFAKYLGACGRMVAVNYVGE-ELW---------------------SYFNAPWEKRV 261 Chinese pangolin
Q1RLQ5       270 KIFIGLLELIEDIFHGTFGS-FLMCDMRASSFGYT-DRHDLRLVDGRRVVAEEAFKQAMiL-QRCKD-----H------- 334 zebrafish
XP_002434016 243 HLANRLLDLAQLLTENPTEFaLYLTDVSMDNFAVD-AMGQVTVVDAENVIVVDQ--REVrEgQKPGW-----Dkry--eh 312
XP_002432435 116 LLSIKLLNLANFFTFSSSDFiFYFTDISLYNIVVD-EHGNVSLVDLDNVIIFDKKSQKSsS-VKAKIhkteiW------- 186
XP_419100    250 DIALSFLDMVQHFDNDFSHR-LHLCDIKPENFAIR-HDLTVVAIDVDMAFFEPKMRDIL-E-QNCTG-----D------- 313
1_pfamImport  67 GVALSFLDMVRHFDHDFAHR-LHLCDVKPENFAIR-SDFTVVAIDVDMAFFEPKMREIL-E-QNCTR-----D------- 130
Q8BQT2       246 HIALSFLDMVSHFDSDFSHR-LHLCDVKPENFAIK-RDFTVVAIDVDMAFFEPKMREIL-E-QNCTG-----D------- 309 house mouse
XP_011253757 239 KLAVMILNLLEELETEFPEP-LYLCDVKINHFGLPlGGQKLKFLDLDAIFPKSIIDRITaDgKNCEK-----H------- 305
EFX70491     237 HQAKFMLELLDDLHTTFPDP-VHVCDVKLEHFGLL-NG-RQVLLDADTVFPKTVVDRSVgDgRECRK-----H------- 301
XP_002009125 226 KHAISIMEYIFRLEEMKPEP-LRMCKMQVNRFGLT-PDRRLKYQSAEHVYVESYLDKRIsNgVKCHN-----N------- 291
XP_036760196 262 DLAWQLMEIAEQLTNNDFEFaLYLLDVSFDNFAVGpRDGKVIIVDAENVLVADK--RLIrQ-NKPEN-----Wdvwyesk 333 Chinese pangolin
Q1RLQ5       335 -EDCVYgADCRTSCDLSEQRCTAEVAQPNLARACGA-M--KDYL----------LRGA--------PF---HLQEE--LE 387 zebrafish
XP_002434016 313 lEE-AC-HDCLSFSS--EDLCSHQLADHNYFAVCSG-Ll-APRAfyss--vgglLHSV--------PP---DVEKQhgLS 373
XP_002432435 187 -NDn---DDDYSFSS--SDICSHYLSDHNYYSICTH-I--LSHSdy------glLKEI--------PRtitNLNPD--LE 241
XP_419100    314 -EDCNF-FDCFSKCNLKIRRCGAQRANNNLQVICDK-I--FRRWfs------psLRGPl------vSF---PLQPQ--LQ 371
1_pfamImport 131 -EDCNF-FDCFSKCDLRAHRCGAQRANSNLQVVCDK-I--FRHWfss----srgSSAV--------SS---PLRGQ--LR 188
Q8BQT2       310 -EDCNF-FDCFSKCDLRVHKCGAQRVNSNLQVICDK-I--FRHW----------FSSThr-----sPAvslQLRLQ--LQ 367 house mouse
XP_011253757 306 -EDCDY-FDCRSVCSK-NKRCESPVLNNNLQIICEKiF--LGWT----------LSGTiiipgllmSE---HTTST--LA 365
EFX70491     302 -SDCDL-FDCRSLCNKVLHVCDTPTVNNNLQIVCQK-V--F--L----------DSGLl------iSR---HLPSD--MN 353
XP_002009125 292 -QDCSF-HSCRGLCDAERQACTHIQQNNNFQIFCEHvLlgSGTF----------QPGL--------LSg-iRLPRS--LQ 348
XP_036760196 334 fDDCDK-EACLSFSK--EILCARATVDHNYYAVCQN-L--LSRHatwrgtsgglLHDP--------PS---EIAKDgrLE 396 Chinese pangolin
Q1RLQ5       388 KQLYACMA 395 zebrafish
XP_002434016 374 ALLAACDR 381
XP_002432435 242 FLLNECKK 249
XP_419100    372 KAVQECAE 379
1_pfamImport 189 AAVQECAA 196
Q8BQT2       368 QAVQECAQ 375 house mouse
XP_011253757 366 VLLRQCAN 373
EFX70491     354 RLIKECAN 361
XP_002009125 349 KLVKMCVQ 356
XP_036760196 397 ALLDECAN 404 Chinese pangolin
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