Conserved Protein Domain Family
Microcephalin

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pfam12258: Microcephalin (This model is not part of the current CDD release)
Microcephalin protein
This family of proteins is found in eukaryotes. Proteins in this family are typically between 384 and 835 amino acids in length. Microcephalin is involved in determining the size of the brain in animals. It is a protein, which if expressed homozygously causes the organism to have the condition microcephaly. Organisms expressing the mutated form of this protein in a homozygous manner develop a condition called microcephaly - a drastically reduced brain mass and volume. Microcephalin is predicted to contain three BRCA1 C-terminal domains, the first of which is the probable microcephaly mutation site.
Statistics
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PSSM-Id: 520167
Aligned: 18 rows
Threshold Bit Score: 365.607
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELW63381      191 ESFVVGLHSSFDDLCGNSECGNQERKLIVSTNEVKSDMRISSPVLKTDNSHLPAPSTCLSQLSPQKSMSSLSKEEINCER 270 
9_pfamImport    1 DSFAGGLPVSAEDLCGGSASGTQERNLGEFITERGSGVRAASPVLQTGQLSPSAAPHPLGLLTPRRSTSSPPKAETPQQS 80  
DAA14618      231 NSLAGGLPVSADDLCGGSASGTQEGKLFEFITERGSDVCAASPVLQTGSVGPSAAPCPLDLLTPHRSTSSPPKAETPQQS 310 
5_pfamImport    1 ESISDVLNTSFDDIWRNSENGKHKVKSEKCIQKAKADACLSSPLSKT------ASSSLFERVTPQRSKSNLPVEKRNFQS 74  
XP_056669381  111 EFISDVLNTSFDDIWRNSEQRKRTVKSEKHTREANTDTCLSSPISKT------ASCHLFDSITPQRSKSNLTAENRNFQN 184 
EHB06907      226 ESFAGGLYSSLGDLCGRSGCGNQDRKLGDSVKEIKSDTCSSSPVLKTSNIHPLASSSCLSELSPQKCASDLPKAEVGRLR 305 
EGW04739      230 ESFASCSHSSFDGL-----LGNQERKLGRSVNEMTRMACSASPVLKISSSYSSLSPNHLCQPSPQKAKDRPPKEDISWQK 304 
XP_225006     224 ESFASGSHLSFDGP-----CGDQERKLGRSSNEMARMTCPSSPVLRASSFYGSASSNHLRQPSPQKAADTPSKEGVNQQK 298 
XP_005334413  222 DFFAGGSRSPLDAFRGESRCRNQGSQSGRTTKETRSDTCTSSCVLEIDSTCSPALSGRLCPSSPQRSESPLSEEERSWQK 301 
XP_017168278  250 ESFASGSHSSFGDS-----CGDQERKLGRSANEMTTVTCPSSPVLRASSFYGSASPNHLRQPRPQKAPDSPSKESINCQK 324  house mouse
ELW63381      271 NTSGEMVTPDRKQVEGISKEMFYENYSLAPAL-----LTKDCHLVHSRSKSSSAKRKRMPEDLDLPPKEKLKKKRYSRKS 345 
9_pfamImport   81 GAAGGVVTPVSKPSRPAAQGPSDGKRRLSPVSs----ATKGRPGGRAQRMGSSTKRKKTPENSCPASEKRQKRRRSLGQR 156 
DAA14618      311 RAARGVVTPISKPSKPVAQGSSDGKKRLSPVSs----ATKGRPGGREQHMGSSAKRKKTPENSCPGLEERRKRRRSLGQR 386 
5_pfamImport   75 TLVTEMLTPEKIQFEEISKKIFCD--YMSPSLa----VGKKQSGKSPGPTNSSEKQLKSLMHLNFPSKAKSRKKRYTSR- 147 
XP_056669381  185 TLTTEVLTPEKTHFEEVSKKLFSDKDYLNP-La----IVESHSTKSPRPTNTSEKQLRSLMHINSPLKEKSRKKKSTIKF 259 
EHB06907      306 DLGGETVTPDRRQAQGVSD--LHEVKSSPPATs----AARGHLWLHSVPGSSSAKGKRTSVDLCSPPRSTLKRRRSGQRP 379 
EGW04739      305 DAAGEKAELEREQAAHVSQGMSDEKLCLSPATtgnidAIDE-------PKSCSAKRKRPV-DLGSPPKGKLKKKRYNRNS 376 
XP_225006     299 EATSEVTDSKRKQAAGVSQGMADEKHCLSPTKs----VIEERVVHLE-PKSSPAKRKRTA-DLGSPSKGKL-KKRYKRKS 371 
XP_005334413  302 DAVGEAVAPDGRPAQGVS-----GDRSTAPASt---------VLVHSRPWSASPRRERASVGLGSPPEEQVKKRRLSRKP 367 
XP_017168278  325 DATGAVADSERKQAAGVSQGVPDEKLCLSPTMs----IIEEHQVRLG-PKNSSAKRKRAA-DLGSSPKGKL-KKRYKRKS 397  house mouse
ELW63381      346 IVPRLQMFESENSQQLMTRSAIETLDFGVSSYDDYFSPDNLKERNVENLPPk-AQ-PSSPSLFNCrKSLSKRERASILEK 423 
9_pfamImport  157 PAPRL---RAESGLRSVQRAAVKNLALEEFSYDDYFSPDNLKERVSEGLLg--EQlPSRPPPLHCqRSLSKTERTSLLDR 231 
DAA14618      387 PAPRLRLWKAERGLRSVRRPAVKSLALEEFSYDDYFSPDNLKERVSEGLLg--EQlPSRPPALHCqRSLSKTERTSLLDR 464 
5_pfamImport  148 ---KLHLDKTENFLELMTSPVKISPACKEAIYDDYFSPTNLKEGNSRNCTFeaKQkLQSPSHLKYqKIVYKNKKKSILEN 224 
XP_056669381  260 ATPKVHRDKAENFLELMTTPVKVSPACEEAIYEDYFSPTNLKEGNSKNCTSkvKQiLESPSHLNSqKSVYRSKKRSILEN 339 
EHB06907      380 VGPWEQQLRSSRSLRFPTSAVMGTPDCGVSSYEDYFSPENLQERTSAGHPPv-SRpSPGPAHFSC-RSLSKRERASILEM 457 
EGW04739      377 A-LSIQLFKSDHRPQFTTSPILGTPDVGASSYEDYFSPDNLKERNSEALPPe-AQaLSSPSLFHC-RSLSKWERRSILEM 453 
XP_225006     372 T-PAVQLFKSDCSPQSTTRPIPGTPDVEASSYEDYFSPDNLKERNSGRLPe--AQlLASPSLFRC-KGLSKWERKNMLEM 447 
XP_005334413  368 VTPRSQL-RLERGLLLAARPAPATPDSGE-SYEDYFSPDNLRERGSEQSVPg--SpLPSPMQLGC-RSLFKKRAKSLIEM 442 
XP_017168278  398 A-LAIQLFKSDQSPPSTIRLIPGTPDVEASSYEDYFSPDNLKERNSERLPPe-AQqLASPSLFHC-RGLSKWERRNMLEM 474  house mouse
ELW63381      424 SYFSCISIKNRSVD-ITDLTAKAS-SSPQTPTNDEGNITSSCVTSENPYVTEESSCCRTQAGPQQRENt-CSDEHNFSYI 500 
9_pfamImport  232 ADLSLIGRSPRPAV-GTCSTAKP------GPPPFCGAPGVPRRCVGG-GAAEGPPGPCPWAEAQGEGDa-RPAEGDTLHT 302 
DAA14618      465 ADLSLIGRSPRPAV-STCSTAKP--------ALSGADAGLGGGTSGGTSAADRTPGPCPRAEAQGGGDv-RPAGGDAPQT 534 
5_pfamImport  225 TDFPSVSKKMEPIL-ASDTLVEDN--RLKKLPNYERNVNLNCSSYSEIPDGKETLGCCNEIDSQKREGkiTINGNKCLYT 301 
XP_056669381  340 SDYPNFSKRIKLIE-TSDNLVEECnCTLKKLPNSERNMSLNCNPYSEIPNANEILGCYNEIDSQERERniAIGGNNCLHT 418 
EHB06907      458 SDLSCIGEKSTLVS-ITDLTAKTT-SSLQSPA---------CLAAEDTPAAEESPGCRGRAGSPQGDDa-GPTGSHHPHN 525 
EGW04739      454 CDFTSIGDKPRSIS-ITDSVSRST-SSLEKPDKEEVSTVVE-------TSAKDSPEHCRQPDPQLREDt-ALQGSTHANT 523 
XP_225006     448 CDFTCIGEKHRSTN-ISDLISKST-CSLEKPDKEDVNTASTCLPLLG-TSADDSPGQRRHPGPQPREDt-GPEGSSHPDI 523 
XP_005334413  443 ADFSCIGESPRSVP-VTQLTAKTC-SQLQKPEKCAENPGSSRTAAGETPAAEDGQGGAGQAADARPRR------------ 508 
XP_017168278  475 CDFTCIGEKHRSISsISDLISKSA-SSLEKPVKEEVNTASTCLLLVE-TSANDSPGLCSQPGPQLRDDt-GPEGSSHPDT 551  house mouse
ELW63381      501 IDDPTHLK-----GHHGDLTSLKGNNKEI----KELIDIKSMQK-EGTTSKMLNSSEGQAQSDYKLKFVDDINVEKST-E 569 
9_pfamImport  303 PSGLVPQT-----GPQGDPSPLTGSREEM----EEWTDPQLTQK-DGAPPGTAESAA--AHSEGELSAAGDRAEGRSA-G 369 
DAA14618      535 RSQLIPQT-----GPQGDRSPLKGSREET----EEWTDPQSTQK-EGAPPETTESAA--VHSEGKPSAAGGYAEDRPA-G 601 
5_pfamImport  302 TDESVLMSecmetEHYDNLIALEGDAKEYliskKESTIPMNIQKrENINSKMLNSCEKEKQEDNNFIFKSDAALKISV-K 380 
XP_056669381  419 ADESVLMSqylesGSCDTLVSLERDSKEVlmnkKELIIPMNIQKkENINSEVFNSCESKKQ-DFNFIFKSDAALEKSV-K 496 
EHB06907      526 THDPAGPG------QESSCSPVQGRRAE-----RELVGGRGTQK-EGPEAAVPNSPGRHTQKEFELHFGGDPHEEQSAeE 593 
EGW04739      524 HNSPAHCS-----------MPSKGGSKEE----REPVDVKGSPK-DNTTPPALASSEGEAHS---FNFGGDCNIEKSA-E 583 
XP_225006     524 LYSPAHHI-----------TPLKGSSTET----RDPGDGKGSPK-EGTTPPASASPEGEAHS-CNLSLGEDRNV-----E 581 
XP_005334413  509 --SPAPPE-----EREGDLCPPERSGEDV----RGSLCVQSGQE-RGSPSSVLDPVNAGCFT-SKLNFEADYNVEKST-E 574 
XP_017168278  552 LSSSAHHI-----------TPLKGNSTET----RDPGDGKGSPK-EGSTPPASASPEDEVHI-CNLSLGEDCNVEKSV-E 613  house mouse
ELW63381      570 EKENVSRGHS 579 
9_pfamImport  370 AREAPAQGSS 379 
DAA14618      602 ARGAPAHGSS 611 
5_pfamImport  381 EMENPSRCIQ 390 
XP_056669381  497 EMENPSRYIQ 506 
EHB06907      594 EKENLALGYS 603 
EGW04739      584 EKENKSTGYS 593 
XP_225006     582 EKENVATGYP 591 
XP_005334413  575 EKENLPTAYS 584 
XP_017168278  614 EKENIATGYS 623  house mouse
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