8FW5,7T3B,8ADL


Conserved Protein Domain Family
IML1

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pfam12257: IML1 (This model is not part of the current CDD release)
Vacuolar membrane-associated protein Iml1, N-terminal domain
Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy.
Statistics
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PSSM-Id: 520166
Aligned: 97 rows
Threshold Bit Score: 321.382
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8FW5_A        102 LTFKDQYIGRGDMWRLKKSLVSTCAYITQKVEFAG--IRAQAGELW-VKNE--------KVMCGYIS-EDTRVVFRSTSA 169  human
XP_002681659  247 fSIRDHFLSRSDMWRFGLYLNDTSVYESKTLTWHGg-IRVQVKELMkETTG--------KVSSGIIVyGHTKITYRSNSA 317 
XP_002291433   35 VTMKDQFISRGDMYTFQKSFLNTWVYEGKRLS--NdsIRTNAKVIR-HGDH--------AIRSGIIT-EDTKMTFRSRSA 102 
XP_002182812  432 I--KDQFISRGDMHLFQQNLMGSWIYEGQRLFDATrgIHAHAREIR-HDDH--------QARSGIVT-QDTMITYRSRSS 499 
XP_003284131  100 LSFKDQYIGRSDMWRLKLNLENECVYASKKLSFAQ--IRAQVEEMV-CNGQ--------KVSSGLID-DSTKFVFRSRSA 167 
XP_004360681  352 VSFKDQYIGRSDMWRLKLSLQNECVYVLKKLSFAQ--VRAQVEEMV-SKGQ--------KVSSGLID-ESTKFVFRSRSA 419 
XP_009015872   19 LVFQDQYYSRSDMLRMRNFLMNKILFYEEKIELMK--MRAKVEELW-CNIKiddiwynfRVTCGLIT-DKTRVSFRSSSA 94  
EDO41898      102 ILIKDQYLSRNDMWRLSKALDNTCVYVNKKVSSCG--IRCQIYELW-TKGE--------KVSCGVIN-KDTRIVYRSLTA 169 
XP_003374607  129 LSVKEQYISNSDYYRLRQVIVNTCVYMNKKIEHWG--MRVYVQEMF-RFGE--------RVNAGYVS-ENTKIVLRSSSA 196 
NP_001420385  214 LTFREQYMSRADMYRYRSCLIGRMTYVEEPKRYMN--INTRISDMW-RKGS--------LVRSGYVT-DKTRVVFRSSSS 281  Caenorhabditi...
8FW5_A        170 MVYIFIQMSCEMWDF----------DIY--G-DLYFEKAVNGFLADLFTKWKEKNCSHEVTVVLFSRTF------Yd--- 227  human
XP_002681659  318 VIYWLFQMSREMWEY----------DEY--G-NLIFERVINGFIKTVFDRWREVGVNHSLSIVFFSRHYiteed------ 378 
XP_002291433  103 RIIWLVQLSSEMWEQaspyeasgaqKGAepScHIYFDKFVE-FVRRLFTKWKKLELTHNLTVVYFSRTY------Irhne 175 
XP_002182812  500 RIFWLIQISAEMWDYssp----yanYEDesRcEVYFDKFVK-FAYELFAKWKVVEATHSLTVVFFSRTFlpsrtsVlpa- 573 
XP_003284131  168 KFVLFIQMSKEMWDY----------NSD--G-ELYFEKAVNGFLKNLFQRWKSLSVNHTITIILFSRTF------Hd--- 225 
XP_004360681  420 KFILLIQMSKEMWDF----------ASD--G-DLYFEKAVNGFLKSLFAKWKSLSVNHTVTIVLFSRTY------Ye--- 477 
XP_009015872   95 QVHIFIQMSSEMWLF----------DNY--G-QLYFEKAVDGYLSHLFKLWREKKCSHDVTITLFSRTF------Yd--- 152 
EDO41898      170 QVFLFIQMSQEMWDF----------DLN--G-DLYFEKTIHGFLYELFSKWKEQNATHEVTIVLFSRTF------Yd--- 227 
XP_003374607  197 VVYIMIQMSREMWEF----------DNE--G-DLHAEKCLEGFLPDLFRKWDERNCTHFVSIVLFSRCF------Yn--- 254 
NP_001420385  282 TVLIFIQMCSEMNQL----------DPQ--G-DLYLEKCIKGFLTELFLKWKEQSCTHYVSIILCSRWYa---------- 338  Caenorhabditi...
8FW5_A        228 --------------aKSVDEFPE------InrasirQDHK---GRFYEDFYKVV-VQNERREEWTSL-LVTIKKLFIQYP 282  human
XP_002681659  379 -----------kdnfEETRNEEDhmaslgNrtninhSIIGskdGKRYVDFYKVVdCTETQRIRSQEI-RILLKKEFLEFE 446 
XP_002291433  176 trdefspmnhtapkhSPALHTDAe-------------------GRLFEDHYKIV-VENETRADWQSL-IHRLKKEFVSYP 234 
XP_002182812  574 ------------ignRPADQRDAy-------------------GRRYEDHYNIV-IENETNADWDAL-VLRMKEAFLKYP 620 
XP_003284131  226 --------------sDDILDEFPnip----------rnaQ---GRLYQDFYKVV-VNEESRPDWSSI-IVTLKKEFNDYH 276 
XP_004360681  478 --------------nSEILDEIPnlp----------knkQ---GVLFQDFYKVI-VSEETRQDWNSV-IVNLKREFSNYH 528 
XP_009015872  153 --------------aKSV-DEFPecmkewIr-----EDNR---GRFYEDFYWVV-VQNDRNEDWSKT-IGSLKTIFSTYD 207 
EDO41898      228 ---------------aKFIEDFPperrpcIl-----QDSY---RRFYEDFYHVV-IQREKRDDWLPV-LVTLKHHFTQYP 282 
XP_003374607  255 --------------tEQLKNLPSevyeemMq------NIN---GEYYRDFYHLI-IQNEQFDDWRWV-LEKVRIGFAQFT 309 
NP_001420385  339 --------------iGGVDDAAKrfmkgaC-------DHR---GRYYQDFYRLL-FQNEHYEDWADKqLKEINVGCSKYS 393  Caenorhabditi...
8FW5_A        283 V----LVRLEQ-AE-GFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLM-ILTKQ 355  human
XP_002681659  447 N----MVKGIAe-K-ERVVLQNSSAADSNFMEAINLVLNSYDKYYINRDLTRTGQVILLVSPGSGMFDVQIPVLgKITTK 520 
XP_002291433  235 KevkwDLTPGEe-------RIPSTASQGNILEAINITLNLLHLHYIDRDLHRTGNSIVIITPGNGVFEIEKNLA-GITKQ 306 
XP_002182812  621 YevewNCSAAEd------ARRPSTATQGNVLEAINVTLNLLQYHFLDRDLHRTGNSILVVSAGGGVFEVDKELA-SITYQ 693 
XP_003284131  277 TsvfwDIYGRNs-----ALGKNSTASQGNFLEAINLGMSYFDKHYIDRDFTRTGQMIVVISAGTGIFEVDQDIN-LITKQ 350 
XP_004360681  529 QmvnwDIYGRNs-----ALGKNSTAQQGNFLEAINLGMSYFDKHYIDRDFTRTGQMIVVVSPGTGIFEVDPDVN-LVTKQ 602 
XP_009015872  208 N----DVLHFHedkqlSRASFNSTSSDGNVLEVINMALNVYEKFYMDRSFERTGKMSMIITPGVGVFDVNRELM-NITKQ 282 
EDO41898      283 K----YINCYHdEP-GVPAGCNSTAFDGNILEAYNLTMNIFEKHFVDRTFDRTGQTTVIVTPGPGVFEVDRSLT-SIIKQ 356 
XP_003374607  310 S----KINQSNelk-lkLQGSNTTSSTGNILESLNIPLNYFTKFYKNRSFERTGQLIMVITPGSGVFQVDNDLV-QLTRQ 383 
NP_001420385  394 S----QIQEKLkemlpQVQFEVSTAADGNFLQVVNMSMNSFSMYHSDRRFETTGQQIIFVTPGNGVLHVDRDLV-SLTKQ 468  Caenorhabditi...
8FW5_A        356 RMIDNGIGVDLVCMGEQPLHAVPLFK 381  human
XP_002681659  521 RLMDVGLSVDLIAHSVPPLHSVPIFR 546 
XP_002291433  307 RMMDNGIGSDMLSLGLPPLHVAPFFL 332 
XP_002182812  694 RMMDHGIGSDMLSLGLPPLHIAPFFL 719 
XP_003284131  351 RMIDNGIGCDLICLNNHPLHIVPLFK 376 
XP_004360681  603 RMIDNGYGCDLICLNKHPLHIVPLFK 628 
XP_009015872  283 RSIDIGSSCDLICLGERPLFAVPLFR 308 
EDO41898      357 RMVDSGVATDLVCMAEQPLHSVPLFK 382 
XP_003374607  384 RCLDYGTAVDLVCLGEQPYHVVPLFa 409 
NP_001420385  469 RVIDMGISLDMVCLGEQPLHAVPLFV 494  Caenorhabditis elegans
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