6CES


Conserved Protein Domain Family
IML1

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pfam12257: IML1 
Vacuolar membrane-associated protein Iml1
Proteins in this family contain a DEP domain, which is a globular domain of about 80 residues. This entry includes vacuolar membrane-associated protein Iml1 and DEP domain-containing protein 5/DDB_G0279099. In Saccharomyces cerevisiae, Iml1 is a subunit of both the SEA (Seh1-associated) and Iml1 complexes (Iml1-Npr2-Npr3). SEA complex is associates dynamically with the vacuole and is involved in autophagy. Iml1 complex is required for non-nitrogen-starvation (NNS)-induced autophagy.
Statistics
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PSSM-Id: 403468
View PSSM: pfam12257
Aligned: 101 rows
Threshold Bit Score: 324.846
Threshold Setting Gi: 514655524
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6CES_D        101 ELTFKDQYIGRGDMWRLKKSLVSTCAYITQKVE---FAG-IRAQAGELW-VKNEKV----------------MCGYISED 159 
CCA75102      150 EVFFSDQYLGRGDMWRLSSSLAGKCWHKEQKIN---FVGcISATIKTIF-LHKKEVkslriynpahltrlqaKSAYVSPE 225  Serendipita i...
XP_003035651   60 EFYFQDQYLGRNDMWRLGRQLTGKCIYAGQEVT---FVGsAAARIQHIY-IGGKRV----------------SSAIMTPS 119  Schizophyllum...
EKM82325      138 EFAFQDQYLGRNDMWRLGEQLVGQCVYTGRDIS---FVGvVMGKIQNIY-IKGKKV----------------PSAIVASS 197  Agaricus bisp...
XP_001832863  219 ELVFQDQYLGRSDMWRMGEYLTGQCIYTNQEVT---YIGgIVAKVQAIY-SNGVEV----------------SAGVVTAL 278  Coprinopsis c...
EPS98964      131 ELTFQDQYLGRNEMWRLGSHLVGQCIYIQQDIS---FIGiIGAKINAIH-INGRKV----------------PAAYVTPA 190  Fomitopsis pi...
EED78935      322 ELTFQDQYLGRNEMWRLGSDLVGQCVYIEQEIS---FIGvITAKVHAIY-INGKKV----------------PAAYVSPA 381  Postia placen...
Q4PE51        164 ELYFRDQYVGRAEMWRVFQNLEDTCVYCGQKVT---LAGsVRATIGRIF-IKEKKV----------------TSGYVSAS 223  Ustilago mayd...
SHO80107      101 ELYFKDQYIGRADMWRLCESMVDSCVYVGQTIT---LAVgIRAKIGRLF-IHEHSV----------------TSGYFAPS 160  Malassezia sy...
KDE03048      163 ELYFNNFYLSRPDMFRLTLGLARTCLFVNQRVTsevLIG-ARLRVGAIFnLNNHHL----------------RSAYITDE 225  Microbotryum ...
6CES_D        160 TRVVFRSTSAMVYIFIQMSCEMWDFDIYGDLYFEKAVNGFLADLFTKW-------------KEKNCSHEVTVVLFSRTFY 226 
CCA75102      226 TKIIYRSLTAKCTIFIQLCREIWDFADDGERYYEKVVHSFLPALFRRW-------------KMLSTRHVITIVLISRVFY 292  Serendipita i...
XP_003035651  120 TKSVYRSLSAKVTIFITVCRELWYFAGDGERYNEKIVHACLPTLFNSW-------------RAAGTNHTVTIVLICRVFY 186  Schizophyllum...
EKM82325      198 TRPIFRSLSAKVTLFIQVCRELWEFSGDGERYNEKIVHSFLPALFTRW-------------REANTNHTVTIVLISRVFY 264  Agaricus bisp...
XP_001832863  279 TKSIYRSLSAKVTIYIQVCKELWEFAGDGERYYEKIIHSFLPSLFGKW-------------REAGTNHTVTIVLISRVFY 345  Coprinopsis c...
EPS98964      191 TKTVYRSLSAKVTIFIQVCRELWQFAGDGERYNEKIVHSFLPELFAQW-------------NEAKTNHIVTIVLISRVFY 257  Fomitopsis pi...
EED78935      382 TKAIYRSLSAKVTIFIQVCRELWEFAGDGERYNEKIVHSFLPALFAKW-------------SASNTNHIVTIVLISRVFY 448  Postia placen...
Q4PE51        224 TKAIFRSESAKYNLFIQLSREMWEFDEDGEIYYEKALQGFIPELLRRW-------------RAVPTNHILTVILFARVHY 290  Ustilago mayd...
SHO80107      161 TLSIFRTETARCSVFVQMSREMWEFDESGEIHYEKVLYGFLPDLIRKW-------------ETIGTSHVVSIVLFTRVLY 227  Malassezia sy...
KDE03048      226 TKIIFRSESARCFIFVEISQEMWHFEEDGSMLRERC-EVFLDEVFQHWsgkqrkgmggaknRGYSTSHTVSIILYGRVIY 304  Microbotryum ...
6CES_D        227 DAksvdefpeinrasirqdhkGRFYEDFYKVVVQNERREEWTSLLVTIKKLFIQYPVLVRLEQ----------------- 289 
CCA75102      293 DSseieyaag----piqrdddGRAYKDFFKVVTDIEVIKDWKPTLNAMKESLIAFQRDILLTHhyhqh------------ 356  Serendipita i...
XP_003035651  187 DQsevdyaag----pllrddrGNWYKDFYKVITDLEVIHEWRPTLVTLKTSFYDFQRDVLLTHhyhmha----------- 251  Schizophyllum...
EKM82325      265 EEsemqgpvr---dgallderGMWYKDFYKVVTDNELIREWKPILVSIKTAFWKFQREILLTHhyraaq----------- 330  Agaricus bisp...
XP_001832863  346 EEseidyaag----plrrderGNWYKDFYKVITDLEVNYEWNDTLVSLKNSFWAFQRDILLAHhyhracld--------- 412  Coprinopsis c...
EPS98964      258 DSsetvyaag----plrqddsGRWYKDFFKVITDLEVLYDWRPTLVDLKTSFWDFQHDILLAHhfhraalta-------- 325  Fomitopsis pi...
EED78935      449 DEselkdaag----plrrdeeGRSYKDFFKVITDLEVLSDWKPTLVDLKTSFWEFQRDILLAHhyhrpsss--------- 515  Postia placen...
Q4PE51        291 DEseihmleg----pirqdarGKYYIDYYKVVVDLESNCNWDAVMTTLKEEFFRFQHDILLIRrpisgpaash------- 359  Ustilago mayd...
SHO80107      228 DEserehltg---lpvqrtssGQLYVDYYKVLLELDSSPHWPSVMRRLKEEFFRFQHDILLQPrwtssqvglprqdhetv 304  Malassezia sy...
KDE03048      305 EDngegeear---apmkrhenGTLYRDFFKVIMDLTPSPH-PSIVRTVAQEIQRWHESVLLRTrat-------------- 366  Microbotryum ...
6CES_D        290 ---------AEGFPQGDNSTSAQGNYLEAINLSFNVFDKHYINRNFDRTGQMSVVITPGVGVFEVDRLLMILTKQRMIDN 360 
CCA75102      357 ----ndgtdKPPRLIGQISYAHDGPILEAINLGLNPTEAHYIDRSLSLTGTSTILITPGKGHFRVSKKLLKLTTTRLLDQ 432  Serendipita i...
XP_003035651  252 ----nstepV--RLVGKLSYAHDAPVLEALNLALNPTETHYIDRSLSNTGATSILITPGTGYFRVNKRLLRLTTMRILDQ 325  Schizophyllum...
EKM82325      331 ----eckaeVNPRLVGKLSFAHDGPILEALNLGLNCAETHYIDRSLNLTGATSLLISPGTGYFRVNKKLLRLTTSRMLDQ 406  Agaricus bisp...
XP_001832863  413 -sklglpshI--RLVGQISYAHDGPILEALNLGLNPTETHHIDRSLSLTGATYILITPGTGYFRVSKALLRLTTMRMLDQ 489  Coprinopsis c...
EPS98964      326 -eghpdgeqV--RLVGQLSYAHDGPLLEALNLGLNPTETHYIDRSLSLTGSSSIVITPGTGYFHVSKELLRLTTTRLLDQ 402  Fomitopsis pi...
EED78935      516 --sqvepehV--RLVGQLSYAHDGPLLEALNLGLQPTETHYIDRSLSLTGSSTIVITPGTGYFRVSKSLLRLTTTRVLDQ 591  Postia placen...
Q4PE51        360 eelhadlirDRVHMAGRISSSYEGNLLEAINLALNPFDEHYIDRDLNRTGLSMVFLTAGTGHFDVDKKLLRITTERMIEN 439  Ustilago mayd...
SHO80107      305 ggdeavggrV---LLGRFAQAHEGNVLEAVNLMLNSAEKHYIDRDLTMTGFSFLMLTAGTGHFFVNKHLLRIATQRMFDM 381  Malassezia sy...
KDE03048      367 ---------geQKLTGRIAYAHESPVLEATNLALNSFEEHWIDRDLQRTGLEVLVLTAGTSYYEVPKRLLRLTTERMLYH 437  Microbotryum ...
6CES_D        361 GIGVDLVCMGEQPLHAVPLFK 381 
CCA75102      433 GFGLDVIALGKAPLHATPLFS 453  Serendipita indica DSM 11827
XP_003035651  326 GHGFDLISLAKPPLHQTPMFS 346  Schizophyllum commune H4-8
EKM82325      407 GTVLDLILLTKPPLHTSPIFS 427  Agaricus bisporus var. burnettii JB137-S8
XP_001832863  490 GVVLNLILLTKQPLHQSPIFS 510  Coprinopsis cinerea okayama7#130
EPS98964      403 GFAVELVSLAKPPLHQSPIFS 423  Fomitopsis pinicola FP-58527 SS1
EED78935      592 GFGVGLVSLTKPPLHQSSIFA 612  Postia placenta Mad-698-R
Q4PE51        440 GTGLDLVCLTKMPLHSVPLFH 460  Ustilago maydis 521
SHO80107      382 GLSLDLVCLTQMPLHTVPLFR 402  Malassezia sympodialis ATCC 42132
KDE03048      438 GIGLDLISLSKTPLHTVPLFA 458  Microbotryum lychnidis-dioicae p1A1 Lamole
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