Conserved Protein Domain Family
DNA_pol_alpha_N

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pfam12254: DNA_pol_alpha_N 
DNA polymerase alpha subunit p180 N terminal
This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00136, pfam08996, pfam03104. This family is the N terminal of DNA polymerase alpha subunit p180 protein. The N terminal contains the catalytic region of the alpha subunit.
Statistics
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PSSM-Id: 403466
View PSSM: pfam12254
Aligned: 103 rows
Threshold Bit Score: 50.6196
Threshold Setting Gi: 780170690
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q013X2         19 ARLREQREGDKKRSRIDeaadeadAIE----NVYDELDEDAYRALVAKRREAGvDFVV------NDAGEG-YDDLGEeED 87   Ostreococcus ...
XP_006573639   26 ERLKA-RIHGGRRSDATg-----pQIRle-nPVYDTVPEDEYNALVAKRREQArSFIV------DDEGLG-YGDEGEeED 91   soybean
XP_004970715   30 DRLRAIKEGRTRAADAV-------QVKvd-aPIYDTVAEEDYNALVARRRKEAgEFII------DDDGLG-YAEDGReED 94   foxtail millet
XP_009393418   34 ERLKALRSSGGRRSDAGg-----lQIKme-aPIYDTVAEEDYAALVARRREEArGFIV------DDDGLG-YTDEGQeED 100  wild Malaysia...
RVW55391       27 QRLKALRRGG-RRSDGVg-----fQIKve-dPIYDTVDEDEYDKLVAKRREEFrGFIV------DDNGSG-YGDEGQeED 92   wine grape
EEY54777       22 EEIKRMRDG--VEAEETtsssrlaQYKpqeeSIYKAVTDQEYEELVRQRRQGL-PFVE------NDDGEMgYYDDGE-EQ 91   Phytophthora ...
8_pfamImport    1 -DIKRMRDG--DASAVPvsgsrlaQYKpqedSIYKAMSEQEYEDLVRQRRQGL-PFVE------NDDGEMgYYDDGE-EQ 69  
EDO07062       14 SKIRKQREGTTNALDEY-------EIEdeneRIYEVVTAEEYKDRTSKRKLD--EFIEggeifsDDDYE--YDSESAdED 82   Babesia bovis
ESS34063       13 EKIRRQRRGEAKASEQY-------EVKdenaEIYETVTEEDYQRLKQTRRAQ--EWI---------DGEG-YSDDGE-EW 72   Toxoplasma go...
EGF84424      943 QRLKELRESGNTSLRDY-------EVAgt-aDIFDVVTEEEYNTLSKRTRLED-DFVV------DDNGEG-YANGGL-ED 1005 Batrachochytr...
Q013X2         88 W 88   Ostreococcus tauri
XP_006573639   92 W 92   soybean
XP_004970715   95 W 95   foxtail millet
XP_009393418  101 W 101  wild Malaysian banana
RVW55391       93 W 93   wine grape
EEY54777       92 F 92   Phytophthora infestans T30-4
8_pfamImport   70 F 70  
EDO07062       83 T 83   Babesia bovis
ESS34063       73 W 73   Toxoplasma gondii VEG
EGF84424     1006 W 1006 Batrachochytrium dendrobatidis JAM81
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