pfam12253: CAF1A_dimeriz (This model is not part of the current CDD release)
Chromatin assembly factor 1 subunit A dimerization domain
The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the largest, known as A/p150, which is uniquely required for the progression of S phase in mouse cells, independently of its ability to promote histone deposition but dependent on its ability to interact with HP1 (heterochromatin protein 1)-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. It contains a HP1-CAF-1 interaction module that functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints. p150 plays a key role in embryonic differentiation. This entry represents the dimerization domain of p150.
Jiyao W et al.(2023). "The conserved domain database in 2023.",