Conserved Protein Domain Family
CAF1A

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pfam12253: CAF1A 
Chromatin assembly factor 1 subunit A
The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A. The A domain is uniquely required for the progression of S phase in mouse cells, independent of its ability to promote histone deposition but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints.
Statistics
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PSSM-Id: 403465
View PSSM: pfam12253
Aligned: 138 rows
Threshold Bit Score: 57.898
Threshold Setting Gi: 1051434432
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHA58474            363 KYLRFFQDVRPAYYGTVTSLPPSLAsydksstttlhaarlrklARKPISRQvLPLQYDYDSEAEWVD---DgDGEDIEGD 439 Pyricula...
EIM23186            418 KLLKYHEDYRPGWWGTCTKSSSTVG------------------PRRPFAKDaLQFDYSYDSEVEWGEeepDeKGEEIQSQ 479 Wallemia...
EKM55675            539 KVLIFHEDSRPGYFGTWTRNSREVG------------------PRRPFGKDvVSIDYSVDSEAEWEDd---eEG-DVLED 596 Phaneroc...
EPT05850            477 KVLVFEEDARPGYFGTWTRSSHAVG------------------PRTPFARDvLALDYSYDSAEEWEGe-eEsGGDDVVED 537 Fomitops...
XP_007847649        450 KVLIFTEDLRPGYFGTWTRSSRIVG------------------SRSPFARDvIDIDYGYDSGEDWDEgesAgAGDDVV-D 510 Moniliop...
EGN95488            429 KVLIFEGDARPGYYGTWTRNSRVIG------------------PRTPFARDmLVLDYGYDSGEEWEAe-aPgDADDVVED 489 Serpula ...
XP_001878585        506 KVLIFTEDARPGYFGTWSRSSRIIG------------------PRTPLAKDvLVFDYGYNSGEEWEQe-aAgDADDVADD 566 Laccaria...
WGS:AACS:CC1G_10826 478 KAFIFHEDARPGYFGTWTRNSKVIG------------------PRRPLARDlLTFDYGYDSGEEWEEe---pVGDDVA-D 535 Coprinop...
XP_003035961        438 KVLIFHTDSRPGYYGTWTRASDVIG------------------PRTPLARDaNQHDYGYDSGEEWEd--ePvEADNV--D 495 Schizoph...
EED81075            237 KVLIFDEDARPGYFGTWTRNSREVG------------------PRAPFARDvLSLDYAYDSGEEWEEe--NgDADDVV-E 295 Postia p...
EHA58474            440 DDDDDDdedDD-EDM 453 Pyricularia oryzae 70-15
EIM23186            480 PGSDDEkdkDNeSDA 494 Wallemia mellicola CBS 633.66
EKM55675            597 AGDEDDedaGAaEDA 611 Phanerochaete carnosa HHB-10118-sp
EPT05850            538 ADEEEAgdgEDdSDM 552 Fomitopsis pinicola FP-58527 SS1
XP_007847649        511 DDEEDAdsdGQdSDM 525 Moniliophthora roreri MCA 2997
EGN95488            490 GEEDDNdgdDAdSDl 504 Serpula lacrymans var. lacrymans S7.3
XP_001878585        567 GEDEDPeneDVdSDL 581 Laccaria bicolor S238N-H82
WGS:AACS:CC1G_10826 536 DDEDDNeteDHdSDA 550 Coprinopsis cinerea okayama7#130
XP_003035961        496 EDDEEGvdeEEdSDA 510 Schizophyllum commune H4-8
EED81075            296 DAEEDEagdEEdSDL 310 Postia placenta Mad-698-R
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