6WTG


Conserved Protein Domain Family
SidE_PDE
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pfam12252: SidE_PDE (This model is not part of the current CDD release)
SidE phosphodiesterase (PDE) domain
This entry represents the phosphodiesterase (PDE) domain found in the bacterial ubiquitinating enzymes, which belong to the SidE family. This domain catalyzes the conjugation of ADP-ribosylated ubiquitin (ADPR-Ub), previously synthesised by the mono-ADP-ribosyltransferase (mART) domain, to a serine residue on substrates to generate a protein-phosphoribosyl-Ub (PR-Ub) product. These pathogen proteins are secreted bacterial effector proteins, which are translocated inside the host cell using the Dot/Icm secretion system. The SidE family of enzymes carry out ubiquitination of host cell proteins in an E1/E2-independent manner.
Links
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Statistics
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PSSM-Id: 520162
Aligned: 29 rows
Threshold Bit Score: 109.105
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6WTG_A          1 MPKYVEGVELTQEGmha----------------------------------------------ifARMGYGDITSGSIYN 34   Legionella pn...
Q5ZSJ4        509 KDYLSKPYDQSEKGkdpnggd--------------------------------------wtlncgNNKTLHRPNHGLSHT 550  Legionella pn...
WP_058531454  440 THHLSKAYKETHLDstda-------------------------------------------elkqDSQVIYRPNHGLAHS 476  Legionella ru...
WP_058531521  442 THHLSKAYKETDMDstda-------------------------------------------vlkhDNQVIHRPNHGLAHS 478  Legionella ru...
WP_115303411   59 DDYLSQPYKETNTKgtvsnhwswhpimvkkgn---------------kfhfyqtlksfyedghtkDTLAVYRPNHGLCHT 123  Legionella be...
WP_045095123  675 NKFLSKKYTEERAGtyfpilykqngnt-------------------------isgltshydcyngDEAAVYRSNHGLCHT 729  Legionella fa...
Q5ZTK5        254 KEYLGKPYPGPLKNpkape-----------------------------------------egrlpPNEGPDRGPHGLAHT 292  Legionella pn...
Q5ZYX7        246 DNYLGKPYTGTVEAtpv----------------------------------------------nfGGQMVYRQHHGLAHT 279  Legionella pn...
WP_058520520   35 NSWLKEPYIKVNSDvafdaqmqkekmlfprldlslesyskskfytersksgvlvhsaqlcdimidKWGKVNRPNHGLGHT 114  Legionella tu...
Q5ZVE4        314 SNFLKHPYNPKLKQpdanvkaawekhadw----------------------ehwsnmgqdwslntPSGLVPRPNHGIAHT 371  Legionella pn...

6WTG_A         35 GVPTIDTGALNRqgfmpvlTGVGPHRDSGHWIMli-----kgPGNQYYLFDPLGKTSGEGYQNILAAQLp---------- 99   Legionella pn...
Q5ZSJ4        551 LRGAALVPEVLYs------YATHSTDKKTRDMVqn-----isKDDIKRMQVAMLFSVVGRKSELGFADNpg--------- 610  Legionella pn...
WP_058531454  477 LRVAAAIPLVVE-------YFQQFAQPELRKQClq-----lsGDELKKAALCMLFSVSGRESDIAFKSNpe--------- 535  Legionella ru...
WP_058531521  479 LRVATYIPLVVE-------YFQQFAKPKLSQLCqn-----lnSEELKKLQLCMLFSVSGRESDLAFKSNpd--------- 537  Legionella ru...
WP_115303411  124 AKTMVLVNDVVEf------NKAHASDPVKQYINqqintpekkQKFITKLQIAMAFYVSGREGEEGWEKDldr-------- 189  Legionella be...
WP_045095123  730 ARTQFLVRMVVDf------NLKYAAPDIQNHIMaqld--sqgESFIAKLQIAMAFYVSGRESESGFGTEe---------- 791  Legionella fa...
Q5ZTK5        293 VRTMACAEVMIEearkaqlRGETLGKAKNGQTLad-----vtPEELKKILIAQAFFVVGRDDERSGYDDvhkr------- 360  Legionella pn...
Q5ZYX7        280 LRTMAYAEIIVEearkaklRGESLKTFADGRTLad-----vtPEELRKIMIAQAFFVTGRDDEES-SKNy---------- 343  Legionella pn...
WP_058520520  115 LRTAAYIPMVVEe-----fKKHHPEYEHLK------------EEDIKKIQYLALFSIVGRLNECGWADSlt--------- 168  Legionella tu...
Q5ZVE4        372 LRVAQLVPVIAEf------LKAYSGDPKFQKLT---------QKEIQKAQYMMLFSVIGRENDMSWTDAnhyqqafkeay 436  Legionella pn...

6WTG_A        100 ---------MGSTLSVIPNGSGLNmglagywv---asaglraHQAL-NQHNPPT----------LLNVGQTITNEMRNEL 156  Legionella pn...
Q5ZSJ4        611 -------vyGGYRRASADLFEEYAkthykd-------lftskEQIA-YWKRLVLdygn--pgfhPDVNKPEQAIIAKIMR 673  Legionella pn...
WP_058531454  536 -------kyREYREQCALQFAAYAqkk------------mpsDEIK-KYMELIRnmgnp-eyltSKKITPQKAALFHVMN 594  Legionella ru...
WP_058531521  538 -------kyREYRQRSAEQFILYArdk------------mskDDVK-KYAELILnmgnp-dylkSKKITPKKEALFHIMN 596  Legionella ru...
WP_115303411  190 -------pyHKYRKSSAKNFKKYIrdnelip-----nlfsseEEVK-IYAEHLThsyiddgfdiEAPENAEAAAIKAILY 256  Legionella be...
WP_045095123  792 --------yDRYRKQSAQNFKDYVheknlip-----tlfqneAELE-TFASCLEhsyltddpeqLIKLSAEQKALKVLMY 857  Legionella fa...
Q5ZTK5        361 ------nfyAEYHEKSEQAFRKYVednklig-----kifkdqKEVD-FYAAIIL----------DKNHEWDATPAHILIN 418  Legionella pn...
Q5ZYX7        344 ---------EKYHEQSRDAFLKYVeenkstli---pdvfkdeKDVK-FYADVIE----------DKDHKWADSPAHVLVN 400  Legionella pn...
WP_058520520  169 -------tySYFRWRSGEIFYDYMmqtiegeprykslgfkdeEEVNhYKQQLL-----------EMGEPNNKDPIHVILN 230  Legionella tu...
Q5ZVE4        437 ngqyskhiyATFKENAQKGFLNHVvtnkssli---pslfsdeSELQ-YWAEAL-----------DTGKPGISSASGILMA 501  Legionella pn...

6WTG_A        157 DHDGYRKITGW-----LRAVADEFPEGDPQLDGKALREN--------------------TEK 193  Legionella pneumophila subsp. p...
Q5ZSJ4        674 QCHCLDLLRCYskeefTK------KVTKPLQDDLGVDAA--------------------NNL 709  Legionella pneumophila subsp. p...
WP_058531454  595 LAHKLDLMRCYplaqyQLavmkghdpli---------------------ipsekqqhqfNRL 635  Legionella rubrilucens
WP_058531521  597 LAHQLDLMRCYhfaqySIaianghdsli---------------------ipsntqqrhfNAL 637  Legionella rubrilucens
WP_115303411  257 GAHCADLSRLWspskiNK---------DTLWDLFRAVPAdkvdsckkhpkanleiihqaKAI 309  Legionella beliardensis
WP_045095123  858 GAHCADLSRIWtpnkiEN---------NTIFDLMKAVPLkdnqe----------arhaaLLI 900  Legionella fallonii
Q5ZTK5        419 QGHMVDLMRTK-----APAEVALERTYNTLKGTVGSKGA--------------------EVV 455  Legionella pneumophila subsp. p...
Q5ZYX7        401 QGHMVDLVRVK-----QPPESYLEYYFSQLQPWIGSTAT--------------------EAV 437  Legionella pneumophila subsp. p...
WP_058520520  231 TAHKIDLMRCS---------SKSNPFKGRFDDYLKEFLPid----------------siQKL 267  Legionella tucsonensis
Q5ZVE4        502 LAHDLDLMRCYdkgkfNS------LKMKDLVARLGGNEDa------------------aKKL 539  Legionella pneumophila subsp. p...
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