Conserved Protein Domain Family
MKT1_N

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pfam12247: MKT1_N 
Temperature dependent protein affecting M2 dsRNA replication
This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the N terminal region of MKT1.
Statistics
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PSSM-Id: 403459
View PSSM: pfam12247
Aligned: 78 rows
Threshold Bit Score: 59.4225
Threshold Setting Gi: 154342039
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_013024312          354 PNDISAYMGTRLPNELYYYISRGLLPSRMIGALVSGCFSD-PVSIleqhvgdsssqevnekpdltsrkNAaaLAAVNQRR 432  Schiz...
LoveMIT:GQ68_04963T0  338 PNDLHDVIGQRLSNELYFYISLGLINFELLESIIYDHYLE-RLPL-----------------------DA--QVTQLYEK 391  Komag...
EFA78219              312 PSDLNSIFGPRLPNDLYFYLSQSVVSPQVINNLISGVLFE-PYPT---------------------------ADSEEYRR 363  Heter...
XP_004366362          306 PTDLNSIFGPKLPNDLYFYISQGAVSPQVVNNLISGILIE-PFPT---------------------------VESEEFRR 357  Caven...
Q54UD1                348 PYFLNQIFGPRLPNDVYFYISQGVVSPQVINNFISGVLAE-PFPT---------------------------IESEEYCK 399  Dicty...
XP_001566971          334 rCEIRPIFGSPMPIVFFYLFMSGPLLPLPFAIHSQEVLAD-DWPL---------------------------IDTSAYRR 385  Leish...
Q38C92                712 PTNLAGVLGHLVPLSLFYMQFSGLLSVRIMTAITQSYLRD-ECPV---------------------------SDTKDYHT 763  Trypa...
XP_001465395          555 PNNLSGVFGYLVPLSLFYFQFTGLLSVGLMTAVTQLYIRD-EFPV---------------------------ADTEEYHH 606  Leish...
EFC40095              307 PRDFEEIVGERLPEEIYFLICHGILSPQLVGNLVNGVFYE-PNPL---------------------------FDSLEYKE 358  Naegl...
Q4UAD3                298 PSDYHKIVGSKLPKPLYYLLSEGLISVQLPFALALGEWIDePNQN---------------------------ADSLEFRD 350  Theil...
XP_013024312          433 FVDDLE--EIWSQGL-NLL--TQPLHRFYQARDV 461  Schizosaccharomyces cryophilus OY26
LoveMIT:GQ68_04963T0  392 ITIGDDsiELKGKVL-NVL--TSFLNRYYQVKRL 422  Komagataella phaffii GS115
EFA78219              364 MLEYLK--EIRTNTL-GLL--SCTLNEEISNKSI 392  Heterostelium album PN500
XP_004366362          358 MLEYLK--DVRAKTL-GLL--SACLGDDIHNKVV 386  Cavenderia fasciculata
Q54UD1                400 MLDYLK--NVRTKTL-GLL--SICLNDDLKHKPV 428  Dictyostelium discoideum AX4
XP_001566971          386 AAESIL--PLRVQVVfQLFpiAPKTSDFYWIRQY 417  Leishmania braziliensis MHOM/BR/75/M2904
Q38C92                764 TLGLLM--TMRSQVI-GQI--LKRIAHPPPIKRT 792  Trypanosoma brucei
XP_001465395          607 LLHPLM--ALRGQII-SQM--VSRIKADAHGQRL 635  Leishmania infantum JPCM5
EFC40095              359 FINTWK--PIYTSSL-NYL--TSEMNDYFKHKNV 387  Naegleria gruberi
Q4UAD3                351 LLTDLR--EYQCRAL-GLL--VMKLDDQFRTKQI 379  Theileria annulata
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