Conserved Protein Domain Family
MKT1_C

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pfam12246: MKT1_C (This model is not part of the current CDD release)
Temperature dependent protein affecting M2 dsRNA replication
This domain family is found in eukaryotes, and is typically between 231 and 255 amino acids in length. There is a single completely conserved residue P that may be functionally important. MKT1 is required for maintenance of K2 toxin above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae. MKT1 is a 93 kDa protein with serine-rich regions and the retroviral protease signature, DTG. This family is the C terminal region of MKT1.
Statistics
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PSSM-Id: 520156
Aligned: 80 rows
Threshold Bit Score: 125.771
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002545700 533 RTLYLYGILNDk-----KEVSPLAKVLIKFANEIdvsqqeefEQFVLLLLLLQSKSIVLNePSKEFTDvsnyykqwgsss 607
Q6FP97       556 RTLVVLGFFDCniskkeLTPTKWGEVLMKLPELQvsk--dyiEPIFILMVFLKLDVLELGkDTVPSTTsa---------- 623 [Candida] glabrata
P40850       574 RLLVLLEFFTFdfkeklLEPTRWGEVFLKLNELNids--kyhESVIIFLVFLKCDVLKLDeEVQPPAPsa---------- 641 Saccharomyces c...
XP_003675123 550 RMLYQLEFFDFdssknlLKPTKWGTILLKLNELEisa--nyfESILIFLMFVKMNVLSLSeELKPVVRfa---------- 617
XP_003668678 568 RVLTQLEFFDFniptksLKPTKLGSVLLNLPKLSidd--khyDSILLLLIFLKTKVMSLSeDVKPSVRsa---------- 635
XP_003959380 582 RSLVQLEFFEYnfsqriLKPTKWGEVLLKFNDLSids--kfhERLLVLLVFLKLDTLKLSeEIKPVVRsa---------- 649
CCK70425     563 RLLIQLEFFDFdfgeksLTPNQWGRAFLKLGNLGaes--dfvGKLFILLVFLKTKVLSISqDFTPSVRss---------- 630
XP_002555402 545 RFLSLLGFFDFdssqktLKVTPWGRILLDMTKTGvds--esiEPVFVLLMFLKTGVLSLReETVPATPsa---------- 612
XP_003646944 518 RFLYLLGFFEHdn---gLQPTPYGKVLLKFGELGine--sfyEMYLVLLMFFKIDVLKLSeETRPPTQsa---------- 582
Q755V4       517 RLLSLLGFFKYes---tLKPTKYGEALMKFNELNlel--efyEPFLVLLMFFKLGVLKLGeETQPPTQsa---------- 581 Eremothecium go...
XP_002545700 608 tdqpqqsgtgaQYKRDsISQedLKKITLISRIFSFNKFNIGPIN-YQGPVSRSLLNFRSQIEFLNKNLLNSLQVVLVDLI 686
Q6FP97       624 ----------lSEATLrSYPdaSQHILIIARILTLFQIKQKPSN-YHGPIDKKTLVFRDHLAFVKENLNELFEAITVSSL 692 [Candida] glabrata
P40850       642 ----------lSQATLrSYPeeSLYVLLITRVLTLFQVDQKPSN-YHGPIDKKTLIFRDHLSFIKENLNELFEAVLISSL 710 Saccharomyces c...
XP_003675123 618 ----------lSDSTLrSYPqeSQYVLLITRILTLFQVDQKPTN-YHGPIDKRTLVFREHLDFIKKNMNELYEATIVSSL 686
XP_003668678 636 ----------lSDVTLrTYPqeSQYILLITRILTLFQINQRPTN-YHGPIDKKTLIFREHLDFIRENMNEIYEATLISSL 704
XP_003959380 650 ----------lSDHTLrSYPqeSTYILLLTRLLTLYQVEQKPSN-YHGPIDKKTLIFREHLDYVRDNLKNLFEATIISSL 718
CCK70425     631 ----------lSDHTLrSYPqeSKYILALTRLLTLFQVDQKPTAiYHGPIDKKTLTFREHLDFVNDNLNDLFESLVVSSL 700
XP_002555402 613 ----------lSKATLrSYSkeSSYILVLTRILSIFRLQQKPSN-YHGPIDRKTLVFRDHLDYVKENLNDLFEVTLVSSL 681
XP_003646944 583 ----------lSQATLrSYPkeSLCILALTRVLTLFQLNQKPSK-YYGPIDKKTLIFREYLDYIKQNMSELFEAVLVSSL 651
Q755V4       582 ----------lSQVTLrSYPkeSQCILCLTRVLTLFKLRQKPAN-YYGPIDKKTLTFREHLDYVKQNISELFEAVLVSSL 650 Eremothecium go...
XP_002545700 687 VHQEQNEiksfEsKqDW-YNLINNLPFYKSInNYLMGVIGEIYFEIcakqkqgddEVRKKNAMNhlcDFVFqvnlptfni 765
Q6FP97       693 TSGEFDRln-lD-NfNWkKSVVRSMPFKLDTpNTIMAMMWEFFLQKyl------hNGNAKADALslvATDFs-------- 756 [Candida] glabrata
P40850       711 TSGEFNRls-lD-NfGWaRKIVRYLPFKLDSpNTIMAMMWEFFLQKyl------hNGNAKNDALslvATEFn-------- 774 Saccharomyces c...
XP_003675123 687 TANEFDRls-lD-NnEWqKNIVRNAPFKSSSpNTLMAMMWEFFLQKyl------hNGNVKTDAMamvATEFg-------- 750
XP_003668678 705 TANEFDRls-lD-NfEWqSKVVRNMPFKLATpNTIMAMMWEFFLQKyl------hNGNVKTDALalvATEFg-------- 768
XP_003959380 719 TSNEFDRls-lD-NnDWkTSIVHKMPFKLALpNTIMAMMIQFFLQKyl------hNGNAKNDALtlvATEFs-------- 782
CCK70425     701 TANEFDKls-lQ-NhEWqSEIVYHMPFKRSLpNTVMSMMVEFFLQKyl------hNGNIKHDALalvSTEFs-------- 764
XP_002555402 682 AAGEFDRls-lD-NtGWqKKIVAAMPFKLSTpSTVMAMIWQFYLQKfl------hNGNSKSDALnliASTFn-------- 745
XP_003646944 652 ATSEFDRls-lD-NsGWqHKIVNHIPFKLSTpNTVMAMIWEFYLQKwl------hNGQDKQDALalvANAFs-------- 715
Q755V4       651 AAGEFNRiq-lD-NaEWqQKIVGNAPFKVSTpNTVMAMMWEFYLQKwl------hNGQDKQDALalvSNSFs-------- 714 Eremothecium go...
XP_002545700 766 nvhgiNAinKDQLISDFKKSVSFWGKFVKLSEITNGIdkNLISDKFLEEIKQTDIFLQK 824
Q6FP97       757 -----TYksTPDLDEKFQESLEFLQQVKAVAKELANN--NLIKASDASLLSAATDFAis 808 [Candida] glabrata
P40850       775 -----TYksTPNLDEQFVESHRFLLEISKVMQELNAA--KLIDENVFKLFTKAVEFTTT 826 Saccharomyces cerevisiae S288C
XP_003675123 751 -----TYksIPNLEEQFEISHEFLVQVSKVMQELTSV--GLLKKGDQNSFEQAVKFSEd 802
XP_003668678 769 -----TYksVPNLNEQFEHSYEYLMQILKVLKELNAI--GLFDRKDLKIVEEALEFCSN 820
XP_003959380 783 -----TYktIPDLGEQFENAVEYLTQCVNLVKELSSQ--RLMKNDEAALIAKAVEFTKN 834
CCK70425     765 -----TYkcVPNLTEQFDQSIAYLSQCKVLFDELCDM--KLVSKDESELLSEAVTFATN 816
XP_002555402 746 -----TSkvVPNLDEELKRSLDFARQFGQVLGALSKA--NLCEKQDYELVVEAVEFAEK 797
XP_003646944 716 -----THkyVTNLAEELERASNYLKDVGVIFGSMKDL--KLINDADFELFNDALKFSNK 767
Q755V4       715 -----AYkhVPNLEEEMKRALKYLENVKSLLGVMHAL--DLIQESEYELFNDAAAFANK 766 Eremothecium gossypii
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