Conserved Protein Domain Family
PCIF1_WW

?
pfam12237: PCIF1_WW 
Phosphorylated CTD interacting factor 1 WW domain
This domain family is found in bacteria and eukaryotes, and is approximately 180 amino acids in length. This domain is the WW domain of PCIF1. PCIF1 interacts with phosphorylated RNA polymerase II carboxy-terminal domain (CTD). The WW domain of PCIF1 can directly and preferentially bind to the phosphorylated CTD compared to the unphosphorylated CTD. PCIF1 binds to the hyperphosphorylated RNAP II (RNAP IIO) in vitro and in vivo. Double immunofluorescence labeling in HeLa cells demonstrated that PCIF1 and endogenous RNAP IIO are co-localized in the cell nucleus. Thus, PCIF1 may play a role in mRNA synthesis by modulating RNAP IIO activity.
Statistics
?
PSSM-Id: 492471
Aligned: 25 rows
Threshold Bit Score: 181.703
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_002293402 420 KLKTLFDtty----ksGSLTEIQSTHAFHTALFATVIRYSSLSgGqqlndwRGGGMQGAIHEGVFDCLGRWFGknAGTEC 495
XP_002286846 426 KLKSLYErti----lsVSGDLEEYHQYFPQTLFTILLRYDALEg---------AGLQSAIPPSVFHFLHKRFQ--CSWEC 490
XP_002997685 100 kLREMFAkkqg-lggdGSNMAPKDQQQLECALFCLLLRYESLDg---------GGFQAALNEECFDVLLKEFD--CKMEC 167
XP_001418910 198 KLRALYCrtvrgceplTEDVDSDEYQKFACAVFALLMRYESLGg---------AGYQSALAEDAFDVLNEKLG--VSCEC 266
XP_003058243 245 KLRALYSrhslggaplPPE-GSSEHAAFAASVFALLARYDACGg---------AGYQAALGEKAFDVLKKRVG--VGCEA 312
XP_001421800 165 KLRALYEkhsraggddDGDDDVHD------RMFALLLRYKTIHg---------HGFQAACSHDVFRVLHDDLK--VTMEC 227
XP_002506891 326 salvnaaanvvdslndDASNEPKSYVVFHARLFALLLRYKSIHg---------YGFQASVGPEVFELLRRTVG--AQVEC 394
Q4DIJ3       272 dvlitlevhaehvtrlrrlavcTEDGQFLFSLALVLLRYAGLSgGew---qLESGWHAGVPHSVFDALVSAFR--VSVEC 346 Trypanosoma cruzi
XP_002507705 203 KLRHLFAmrsesspplSSD----DISVFQSATFSMLCRYTAAQgGmh---rMSGGHHTALHAAVFDVLQHGLD--VEAEC 273
XP_001417960  40 KLKTLYAn-------aSSKEFVEN--DFLFDAFAMVCRYDAAAgGqf---rFSGGSQASLHGQVFDVLRDCFK--VECEL 105
XP_002293402 496 FASPFNCSLP------------QYFSAFp-----sPDLDGHFGSSGDFFhpSSnaaFLKS--GWYELNPPFSSGIMNNMA 556
XP_002286846 491 FASPFNCWLErrqgsgdivgggRFGCAF-------GDTDAWFGGAGSFFgmDFvsmANEQggGCFQANPPFASNFMESMC 563
XP_002997685 168 FASPLNCRYS------------RFCSAF-------LDTDFAFGSVGSFF--DF---SPRS--GCFEANPPFIPKVIKRMA 221
XP_001418910 267 FASPLNARYG------------QFCSQFgfdedraPDVDAFFGSLGSFFsdDF---APKR--GSFEMNPPFVPETMSRAV 329
XP_003058243 313 FASPLNARYG------------RFCSAF-------PDVDGPFGSLGSFF--DF---APTR--GSFEMNPPFVPEVLLAAA 366
XP_001421800 228 FASPMNAYFA------------RFCSAF-------GDVDAPFGSIGSFA--AF---QPSR--GSYEVNPPFVREVLDEAA 281
XP_002506891 395 FASPLNAFHG------------RYHSAF-------PDVDGPFGSCGDFF--RYcadKIRR--GSFQVNPPFVSDVMSDAY 451
Q4DIJ3       347 FASPLNCTLP------------RYFSAF-------PDTDVFFGCRGNFFalQHl-pPPEEglISLEANPPFDHEVIAAGL 406 Trypanosoma cruzi
XP_002507705 274 FASPLNCHFH------------EYCSLF-------PDTDTTFGSRGSFF--SF---FPAE--GSFECNPPFEEGIVLRCA 327
XP_001417960 106 FASPLNCRWP------------MYYSKY-------GDVDKPFGSLGDFR--AC---KPSG--GAFEANPPFDEDVVARMA 159
XP_002293402 557 QRIEELLEMAtsrQ--L--DVTFIIVVPtc-rDHAT-----ASSASYHSK-KKAKKSEK--H 605
XP_002286846 564 NSMNKTLSQKdedDgnSgvPLMFVIFVPaw-rE--SsgwkaLTESPHLSK-HVVLLQKEdpH 621
XP_002997685 222 DHMTALLNAA---D--G--PLAFIVIIPaw-qE--TegwqqLNASRFNQR-HLLIPQKQ--H 270
XP_001418910 330 EKANDLLDRAanaN--E--ALSFVVIVPlw-kE--ChywsaLLESRHLQHgPDIIDAQS--H 382
XP_003058243 367 ERAEKLLRTAeesD--S--RLSFVVVVPaw-rD--VpmwtaLEKSAFKRGdALIVPASA--H 419
XP_001421800 282 LWCEALLERAeksQ--N--ALTFVFIMPgw-kE--TgafdaLTNSAFLRA-NVLIAAVD--H 333
XP_002506891 452 DAMATALNAAdeaD--S--PLTFVVFVPgw-tE--TsawrkLTASTHARN-SFVVAASD--H 503
Q4DIJ3       407 GRALQWLEDTpstT-----PLSFVFILPdstqTNGIevrrkAEQSQFFRG-DCVLSPHM--S 460 Trypanosoma cruzi
XP_002507705 328 EHVLLLLSRAeelK--T--ALSFAVITPyw-pG--RlawetVASSQYTSH-VERIRRNE--H 379
XP_001417960 160 EHLFECLDAA---S--S--ALTFVVVTPhw-pN--RpcwekMRRSKFCSR-AEVISVRE--H 208
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap