Conserved Protein Domain Family
FXMRP1_C_core

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pfam12235: FXMRP1_C_core (This model is not part of the current CDD release)
Fragile X-related 1 protein core C terminal
This domain family is found in eukaryotes, and is typically between 126 and 160 amino acids in length. The family is found in association with pfam05641, pfam00013. This family is the core C terminal region of the fragile X related 1 proteins FXR1P, FXR2 and FMR1. These different proteins have different regions at their very C-terminus. The Glutamine-arginine rich region facilitates protein interactions. This family contains two blocks of RGG repeats that bind to G-quartet sequences in a wide variety of mRNAs.
Statistics
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PSSM-Id: 520148
Aligned: 17 rows
Threshold Bit Score: 114.546
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011472494  354 HISYLNEVEQLRLERMQIDEQLRQITQGHR-PVDRERGERGGG--INADssANASSSSSHGSRS----YNGR-GRGRRG- 424
9_pfamImport    1 HLNYLKEVDQLRLERLQIDEQLRQIGGGGGgGGAGPRNPKDKS--YVFDngMGMGMGRGAGGGKp--yVGGRgGRGRRGg 76 
XP_007256837  354 HISYLNEVEQLRLERLQIDEQLRQIGLGYR-PVPGRPAEKDKG--YNTD--ESASNAPLHSSRS----YAGR-GRGRRGm 423
10_pfamImport   1 HLNYLKEVDQLRLERLQIDEQLRQIGGGSR-PQAGR-SDKDKG--FVSD--DGPGVGPSRGGKP----YGSR-GRGRRGp 69 
6_pfamImport    1 HLNYLKEVDQLHLERLHIDEQLRQFGG----AGAGPRMPKEKH--FLLDngVDPGSGRGA-------------GRGQAA- 60 
3_pfamImport    1 HLNYLKEVDQLRMERLQIDEQLRQI-GGSG-GGSGPRNPKDKA--YVFDngMGLGMGRGGGKPY----SGGRgGRGRRGa 72 
4_pfamImport    1 HVSYLQEVEQLRLERLQIDEQLRQIGVGYR-AAPGR--------------------------------SGGP-GPDREK- 45 
XP_001369634  364 HLSYLQEVEQLRLERLQIDEQLRQIGLGFRtPGSGRGNSSGDKtgYATD---ESSSSSLHATRT----YGGR-GRGRRTg 435
XP_036751803  364 HLAYLQEVEQLRLERLQIDEQLRQIGLGFRpPGSGRGSGGSDKagYTTD---ESSSSSLHTTRTyggsYGGR-GRGRRTg 439 Chinese pangolin
XP_064408914  354 HLSYLQEVEQLRLERLQIDEQLRQIGVGFR-PLSSR-SDKERG--YTTD----DSTSSLQGTRT----YGGR-GRGRRGg 420 coelacanth
XP_011472494  425 -YSTGYGTNSEQSNASETESERKDELSDWSLAGEDqereRERGPRPLR-DGRRR--PGPGRGRG 484
9_pfamImport   77 gAAFTSGTNSEASNASETESDHREELSDWSLAPTEel-mTGGGSLPRRtDGRKRagGGGLRGRG 139
XP_007256837  424 hYTS--GTNSEHSYASETDSERKDELSDWSLAGEE----PDRGVRPQR-DSRRR--PLVGRGRG 478
10_pfamImport  70 --gFASGTNSEASNASETESDHRDELSDWSLAPTD----EERDVFTRRgDGRKR--GGGSRGRG 125
6_pfamImport   61 ---MASGTNSRASNASEASSEHKDELSDWSLAATDeq-aPGSGVLPRRtDDRKR----GMKGRG 116
3_pfamImport   73 gASFTSGTNSEASNASETESDHRDELSDWSLAPTEel-mTGGGTLPRRtDGRKRggGGGPRGRG 135
4_pfamImport   46 ------GTNSELSNASEPEDGAEREQRPRGLGGEE--------------RGSRR----GGRGRG 85 
XP_001369634  436 --sSGYGPGSDLSTASETESEKREE-PDRPGHGD-----QDTSSRGE--EGRRR--PMGGRGRG 487
XP_036751803  440 --gPAYGPNSDPSTASETESEKREEPN-RAGPGD-----RDPPTRGE--ESRRR--PIGGRGRG 491 Chinese pangolin
XP_064408914  421 nANSGYGTNSELSNASETESERRDD-HDRPYGGD-----RDLKQRAD--DGRRR----GGRGRG 472 coelacanth
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