9COP


Conserved Protein Domain Family
Rav1p_C

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pfam12234: Rav1p_C (This model is not part of the current CDD release)
RAVE protein 1 C terminal
This domain family is found in eukaryotes, and is typically between 621 and 644 amino acids in length. This family is the C terminal region of the protein RAVE (regulator of the ATPase of vacuolar and endosomal membranes). Rav1p is involved in regulating the glucose dependent assembly and disassembly of vacuolar ATPase V1 and V0 subunits.
Statistics
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PSSM-Id: 520147
Aligned: 58 rows
Threshold Bit Score: 684.682
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
9COP_x        573 TRTYKAIVNYNDRHVQWIKACEIN--TGIMNCTCIRGSST-GKLCIV---NSTGKVMSLWDLNRGVL----EYEETF--- 639  brewer's yeast
XP_067515704   66 ilfYSMYITSDDASIEWNVLYTLDlpSSL-SIQHIRYCSP-NIVAVVs--GDNSTQLSIWTGMRAGIapvcEQKISF--- 138 
4_pfamImport    1 -EVRTAQ-ADTTTKLRWVVKASFS--QASLPPKLISCSSE-GLIALLycdDQEVQTLVILNPKTASFnsgqEHRHCFe-s 74  
XP_012193139  653 FEAMHAT-RDTRGQLRWTAVALLR--ESSGIPQRVRCNVD-GLFAAVtrdDQGTETLVIFDLKTSSFssgeEHRQSFg-a 727 
XP_002171588  576 LQTWTATV-TSDNTPRVLELSRVQ--TSVRDATLIKGSTS-KIVAVV---SENGSRLSVFDMRSSEFssqeESSAVFp-e 647 
Q9Y817        576 LQTWMARV-LGDDKAEISEISKVQ--TSIKSATMIKGSTS-KKVAVV---SENNRRLSIFDTRSSEFsekeEFSSVFd-d 647  Schizosacchar...
XP_013021115  577 LQTWIAKV-IEPFKASISEFSRLQ--TNIKSSSMVKGSTS-RKVAVV---SDNRLRLSIYDTRSSLFtsneEFTNVFn-d 648 
Q6CBP7        538 FSTWVSEISSDNSTVEWSLLSTVA--TNVINSPLMSQSSL-NKVAIV---SEDRLELSIWDTRHGFL----EQTKKF--- 604  Yarrowia lipo...
XP_036667322  670 gllrsytvDYTKDQLEWVITCSIP--TNVKNAAKINGSTViNKFAVV---DESKRCLSIWDTTQGVL----EYEESFple 740 
1_pfamImport    3 LRIYEAFFEEKSNFINWREKCHIH--TNIPEASRIHGAMTvNKFAVI---DKSGYELTIWDMETQVL----EYKELFdkk 73  
9COP_x        640 HNPIEDIDWTST--------EYGQSIVSIGFTGYALLYTQLR-YDYTNN-----TPSYLPIEKIDITAHTAHNIGDSVWM 705  brewer's yeast
XP_067515704  139 DQSIKDIAWSVT--------SDAQFILAVAFSDHISIYGQKRaYNNGYE------AEWSCYADFKVD--TPEDITALAWV 202 
4_pfamImport   75 AERIIALDWSPS--------TRSTGALAVVFEHHVRVLCPGR-ISMFDEldegmRTSWQELVRFDLRSCTPSSIRAACWL 145 
XP_012193139  728 EESVVGLDWSPS--------PLSSNMLAVAFHHHVDIVAPRR-FSPYEAhdattGSQWQLLVRLDLRSCTSSAIRAACWI 798 
XP_002171588  648 LGPIIDLDWTST--------PNSHSILAVSFKHDVVLICQNR-RSYIMK-----SPLWVPIVRVNTSSFTDLPIRDSTWL 713 
Q9Y817        648 YGPINDLDWTST--------PNSHSILAVGFLHDVILLCQNR-RSYMND-----IPCWSRIRRYNLLEYTNSLISDSSWL 713  Schizosacchar...
XP_013021115  649 YGPIIDLDWTST--------PNSHSILAVGFQHEVILLCQNR-RSYISD-----APCWVPIRRYSLSMYTNMLISDSSWL 714 
Q6CBP7        605 DTKICDLDWACT--------PDNQSVLAIGFGTHVQLWGQLR-FDYTNI-----SPCWGLLKQVDIKPFTNHAIGDSIWM 670  Yarrowia lipo...
XP_036667322  741 NGPVTDLDWTFInatsnensTTSNAILSVGFGRFVLLYTQLR-YDYTNK-----IPTYATIKKIDVSDYTSHAIGDSIWL 814 
1_pfamImport   74 LGSVQDIDWTFItsk--eerSNICSVMSIGFKKVVFLYTQLR-YDYTND-----VPTFATVKKIDISDYTSHDIGDSLWI 145 
9COP_x        706 KNGTFVVASGNQFYIKDKSLDLt---------------------------dPftyqsigSRKILSNDILHLSSVLNGPLP 758  brewer's yeast
XP_067515704  203 DYGVLTVAAGNQLRCYLKWLTEqd-------------------------tvIkssdslnDKMEPMSSIYDISYEMNGPLP 257 
4_pfamImport  146 NSEQLVVASGSVLYVNGPWINSsm---------------------------------qeTAKQETKHLAELLAEVGGPVV 192 
XP_012193139  799 GSEQLVIASGSLLFLYGPFVQPss---------------------------------qvAGEPKKVHLAELVAEVGGPVV 845 
XP_002171588  714 DNGTLVLACGTGIYYFDKTLPQ-----------------------------NpsllypySVNRQSKDLFDLVYQLNGILP 764 
Q9Y817        714 DNGTLVTAIGNGLFYFDNSLPE-----------------------------DqsllfpaSLKRSAKNIFDLAYQLNGILP 764  Schizosacchar...
XP_013021115  715 DNGTLVTAAGNNLFFFKNKIPN-----------------------------NksllfpaSLKRSANNIFDLAYQLNGILP 765 
Q6CBP7        671 NTGVLVVAAGNQLFVDDNCVHEeea-----------------------gvrDfsdmlhsSRAFHIHHLFEICSIVNGPLP 727  Yarrowia lipo...
XP_036667322  815 DKGYLVIGCGNQFFIDDRWIKLgsstidsti------------rqlmsgyvDkpqeetrDKENIVYDISQLVRVLNGPLP 882 
1_pfamImport  146 DSGHLVIGCGNQLFLDDKYVQLdgassspidtilrelmigytnnekdgkqkErtstsykMKQNFIFNLELIVLALNGPLP 225 
9COP_x        759 VYHPQFLIQAIYANKLQLVKELLLRLFLALRkldFESQDv-SNLDSNLGMDPLKYF-----IAKDRDy------------ 820  brewer's yeast
XP_067515704  258 FYHPDHIIHYIMWGKMELVHNVFLTMYGFLK---QFVDEedNVMNELPPVSFSNML-----KLQDINgstkknkggyd-- 327 
4_pfamImport  193 QYHPAFLLQCAQWGKMSVAKAIIGNLEKATL---GCNKDevAGTWDYEEIPIHQVL-----QNDASGagskaavsdnr-- 262 
XP_012193139  846 QYHPAFLLQCAIWGKMEVAMAVISNLENAVL---AYDGQdtGDSWAFQEVPLDAVL-----LHDSAAgngrtrsalpsr- 916 
XP_002171588  765 VYHPQFLQQLMLNNKISLILLILHRVYECLQq--------nNPLHFLLNIEAEKLIlpsaaQDDVQSqvnsvldeiksgn 836 
Q9Y817        765 VFHPQLLQQLLLRNQPFLFTNILLRFYLCLKd--------dVDMHFLLNMDCSEFY-----CCDEEIskdllikslsqn- 830  Schizosacchar...
XP_013021115  766 VFHPQFLQQLLLKNQEFLIRKILLLFYICLKn--------dYPMHFLLNMDCSDFY-----EHNDEKlmekffevltty- 831 
Q6CBP7        728 AYHPQLLVQCILAGQLTVVRDTLYRLYKELQ---YANQElvQDMDSTLGMDPSDYE-----DGDKSGs------------ 787  Yarrowia lipo...
XP_036667322  883 IYHPQFLIQALFMSQIIPVQNILVKLFQALRhgqAIEWDlgIDFAQEMEKHLEPTT-----NGSSKIkplq--------- 948 
1_pfamImport  226 VYHPQFLIQALFMGQVELVKNILVCLFHALRkdeDIEWDlgMDLLSEILGDKEALT-----RNNSSRkidkle------- 293 
9COP_x        821 -------------PVESFPDPYPCFNKTVSLALTEQLTKTTLPYLTRHQQITLITVIEAVDEVTKNENIVDYNGVRFLLG 887  brewer's yeast
XP_067515704  328 --vlfdngdetegTDDEEDEEVRFMTSNEAKNLAHCLKHKNLPGLSKRDKYQLIAMVNTIVEITNQGESIDANGARFIAL 405 
4_pfamImport  263 --rdrrsnvfdddLNFDAQADEDPFAAARIEKLAQILQDIHPPHLTPADLGTLVSIVKMIGETVREHRTLDASGIRYFIA 340 
XP_012193139  917 --htvdgsifdelDRSDDADDSGLFGLDRIDSLAQRIRDVQPPHLSPSDLDVLVNLVKSIGEVAREHRSLDPSGLRYTLA 994 
XP_002171588  837 dsveetavnslneWRNS---------LDWLSSLEAQLKSQKVQTLTRTSQFLLLNFIEAFHKTLSVGSFLDLNGRRYCLM 907 
Q9Y817        831 -saeilnpaeldfEETSVSKHLGLYIDEMIKKLTALLKVKKVKTLTRSSQFLLLNLIEAFNKARALRDSLDLNGKRYCIM 909  Schizosacchar...
XP_013021115  832 -aneipveadsfgEKPSVSEDVTTYMNAFMTHLCLLLKNKKVGTLTRSSQFYLLNVIEAFDKAYHLRESLDLNGRRFCIM 910 
Q6CBP7        788 -----------------------KLLPDEYSNLTEKLQQVSLPFITQHQQVTLASLCEVVAEVAGWS---DIMAIRFYLG 841  Yarrowia lipo...
XP_036667322  949 ----------rrmSQTFNLDVFTKFTDELADLLSDKLMKVSLPLMTRHQQSTLLSVVAIVKELNKYSVTLDDNGIRFMIG 1018
1_pfamImport  294 -------lfsanhDSLSEISVFTTFDDELSSLLIEKLKTTTLPLLTRHQQSTLLNVVSIVSNMDKSVQQYDENAFRFLIG 366 
9COP_x        888 V--KLFLSHKNi--------QKSILMRDVSWALHSDNKEILLSSIDRHITS---WNRAREYRIAYWIKE-QDLVKKFEDI 953  brewer's yeast
XP_067515704  406 VenHFHLNLQLpee----qrQPNLQTRDFTWALHSQSQDLLLQKCMQLCGDkfvWEDARSLGIFLWLQKiDTVREQMTTI 481 
4_pfamImport  341 L--RHMTNGRAstkpdstasRAGLGYRDFSWALHSENQETLLACVEQAYGNkldWSAARATGIFAWLKNsQLVRSQAEAV 418 
XP_012193139  995 L--RQMLNRTDmskqaknapSIELTYRDYLWAFHSDNQETLLAYVESAYPNkldWRAARSAGLFTWLKNpSALRTQAEAV 1072
XP_002171588  908 L--NQYTLLRHqt-----keKSQLPFRDCMWAFYSSNQDVLLGYSKQLLGNfllWDDVRELGLPYWLSQ-SSLCQVFREL 979 
Q9Y817        910 L--NQYVLSKHqr------qLTSLPTREMAWAFHSSNKAVLLDHTKKLHGKpllWNAVEEYAIPFWLNE-QLLKDVFLEL 980  Schizosacchar...
XP_013021115  911 L--NQYVLNKYqr------rSNRLPTRDILWGFYSTNKSVLLDYTVKVHGKtllWPVVEEYGLPFWLNQ-QALINVFGEL 981 
Q6CBP7        842 Y--KLYRMHRKt--------QKQMTVRDFCWALNSESQAMLLEQID---GPklvWPDAQAAGVGYWLEH-HKLVELFDVL 907  Yarrowia lipo...
XP_036667322 1019 F--KLFQLATK---------QKRLSMRDINWALHSDNKEVLLNSVEVFYKNrltWENVKQTGLAYWVKT-ERLIKLIESV 1086
1_pfamImport  367 L--KLFQASAK---------QRQLTIRDCTWALHSKDKEYLFSRVNEYYKNrikWENVAQTGLTMWMDN-DKLPSVIESC 434 
9COP_x        954 AKYEFSk-dDKRDPS-RCAIFYLALKKKQILLSLWKMAIgHPEQQKMVRFISNDFTVPRWRTAALKNAFVLLSKHRYMDA 1031 brewer's yeast
XP_067515704  482 ARNIYLskeDFRDPV-DCTLFYFALRKKNLVQGLWRSASyHKEQGAMLKFLANDFSQPRWQTAASKNAFALLGKQRFEYA 560 
4_pfamImport  419 ARAQFMs-sEDRDPV-KCSLLYYALGKHKVVQGLWRQAVwHPEQKKMLTFLAKDFDEERWRTAAQKNAFALLSQRRYEFA 496 
XP_012193139 1073 ARAQFMs-sEDRDPV-KCSLLYSALGKRKVVQGLWRQAVwHPEQKKMLQFLSHDFDEQRWKTAAQKNAFALLSQRRYEFA 1150
XP_002171588  980 AQNHYTh-nDERNPE-FVSLYYMALRKKAVLVNLWKLASwHKESARTVKLLSNDFTLPRWRVAAAKNAFALLSRHRYFYA 1057
Q9Y817        981 SRNHYAe-iDDRNPE-NVSLYHIALHKINVFRDLWRLASwHKESARTVKLLSNDFSKKKWKVVASKNAFALLSKHRYFYA 1058 Schizosacchar...
XP_013021115  982 SRNHYIn-nGERDPE-KVSLYHVALGKVAVLRSLWSLASwHKESGPTVKFLSNDFTQKRWKVAASKNAFALLSKHRYFYA 1059
Q6CBP7        908 AKNQFMa-tERQDPS-EASLFYLALRKKQVLQALWRSAStHPEQTKMVKFLKNDFSEPRWRTAALKNAFALLSKHRYAYA 985  Yarrowia lipo...
XP_036667322 1087 ARNEFG---ESRDPAgLVSLLYLALRKKQILIGLWRIVN-HEEKTKMLKFMNNDFTNPRWKSAALKNAFVLLGKHRYMDA 1162
1_pfamImport  435 ARNEFS---DTRDPSgLVSLFYLSLRKKHILLGLWRTAS-HSERDKMLRFLSNDFSEPRWRSAALKNAYVLISKHRYLDA 510 
9COP_x       1032 AVFFLLTDSLKDCVNVLCKQVHDMDLAIGVCRVYEG------DNGPVLGELLTAQMLPETIKENDRWKASFIYWKLRKQE 1105 brewer's yeast
XP_067515704  561 AAFFLLADKLRDAVNVILRNVKDYQLAIAICRVYEG------DHSPILREILENTVIPTAIKSNDRWLISMTYWLLGKQK 634 
4_pfamImport  497 ASFFMLGDSLRDAVNVCVRNMDDLALAIALARIKEGg-----DEGPVFRDLLLTRVLPLAFERGDRWMGSWAFWMLKRRD 571 
XP_012193139 1151 ASFFMLGESLRDAVNVCVRNLDDLPLAIALARIKEGc-----DDGPVLTDLLKTRVLPLAFERGDRWMGSWAFWMLKRRD 1225
XP_002171588 1058 AAFFLLGDQCLDAVRVCIRNLNDPALAIAVARVYEG------DDGPTFSKLLVEFMLPISQRYYDRFLACWCFEMLKNKA 1131
Q9Y817       1059 SAFFLLADSCYDAAKVCIRNLKSISLAIAMTRVYEG------DDGPTLKRLINEYVLPLAVSQNDRWLTNWSFTILKQEK 1132 Schizosacchar...
XP_013021115 1060 AAFFLLADSPYDAAKVCIRNLRCLSLAVAVVRVYEG------DGKTCLKRIIEEFVLPSAAYHNDRWLTNWGFAMINEKM 1133
Q6CBP7        986 ASFFLLGDSLKDCVNVITRKLNDTGLAIAVCRVYEG------DNGPVLNELIKNEILPEALKMGDQWVIYWCLWSQDRRG 1059 Yarrowia lipo...
XP_036667322 1163 AYFFLLADKPYDCCNTLATKVEDISLAIAVAKVYFGvqnigkESNEVLVQVMEKFVLPHAITNGDRWSTSWVFWQMNDKQ 1242
1_pfamImport  511 AYFFLLADSLEDCCMVLCRQVKDVWLAIATCKVYEKrgd-keAISKVLRRIIEENLIPDAIEQGDRWLTSWIFRELGEVN 589 
9COP_x       1106 VAIKALLTAPIDLENNssiv--dkeVC-------------------VNRSFLV----------EDPALLYLYNHLRN--- 1151 brewer's yeast
XP_067515704  635 ESIRSLIVPLSQFTDElihdedsaaAV------------------------------------QDPNAFILYHQLKK--- 675 
4_pfamImport  572 LAVRIIVTPLRDLLADp-----------------------------GVASLVKagtacgddnhNDPALALLFSQLRS--- 619 
XP_012193139 1226 LAVRIIVTPLRDLIADk-----------------------------DVASLLGstltcgndsyGDPALALLFQQLRS--- 1273
XP_002171588 1132 KAIQCLVSPLYSTIRDdaelkkettATatllprdd----dalpghpQDKNGAA----------DDPALILLYVWLRDqfc 1197
Q9Y817       1133 KALQSLVSPIRSLVSDndfiqlytsDKndqeihenkdsqrnstnepVRNKFPS----------DDPAFILLYECLRS--- 1199 Schizosacchar...
XP_013021115 1134 KSVQSLLVPVRSLIEVdndliesfgIIgdyplete---tteenhdkTKNEYTS----------DDPALILLYDFLRS--- 1197
Q6CBP7       1060 DAVRSLVSHEYQDKKRgsah-----------------------ivsNSRSFLS----------NDPALLILYQFLRD--- 1103 Yarrowia lipo...
XP_036667322 1243 MSIQSLIKSPMQMIEQsgrgkfaqf-------------lqdvavssKGQSFLR----------DDPVLVLLFNDLRH--- 1296
1_pfamImport  590 NSLEALIKSPISLIETrrgi-fserCQqdyidn--------isvdsTSSSFLK----------DDPLLVTLLQSLKAf-- 648 
9COP_x       1152 ------RNLKYFIGSLNVEAKIECTLILRVTDILCRMGCNYLAVS 1190 brewer's yeast
XP_067515704  676 ------GQTQVLS----VPYDLEYHFSLLVSKAYERLGCPLLALH 710 
4_pfamImport  620 ------KSLQTIKGLYDIPEKKVFDFVLTTNTALCRMGCHSLGLS 658 
XP_012193139 1274 ------KSLQTIKGLYDIPEKKVFDFVLNTNRALCRMGCHSIGLS 1312
XP_002171588 1198 tfggsaSQLRPLGNLAPVNPSHEFKFVLHMARVYDQMGCDLTALS 1242
Q9Y817       1200 -------------SNVQIDESLEYRFVLHNANVYCQLGCDLIALG 1231 Schizosaccharomyces pombe 972h-
XP_013021115 1198 -------------DLLRKDQILEYRFVLNSARVYNEMGCDLIALD 1229
Q6CBP7       1104 ------SKFKVVSSNNGVTSATELQSVFTTAKLYSRMGCEVIALN 1142 Yarrowia lipolytica
XP_036667322 1297 ------RKVDYLKGSLNISPQQEFDFVVRVAMIYSRMGCEYLALl 1335
1_pfamImport  649 -----iKSDKKMKG---ITPGEEYSFILKVCNLYTRMGCDYLAL- 684 
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