Conserved Protein Domain Family
Myf5

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pfam12232: Myf5 
Myogenic determination factor 5
This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam00010, pfam01586. There is a conserved CSD sequence motif. Myf5 is responsible for directing cells to the skeletal myocyte lineage during development. Myf5 is likely to act in a similar way to the other MRF4 proteins such as MyoD which perform the same function. These are histone acetyltransferases and histone deacetylases which activate and repress genes involved in the myocyte lineage.
Statistics
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PSSM-Id: 403446
View PSSM: pfam12232
Aligned: 26 rows
Threshold Bit Score: 41.5738
Threshold Setting Gi: 1316092668
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN60831     141 ENSagqSADSPAASPGA-CSDGM-DLNSPASSSSESSft--wTdgdLYPSTDLLSdfLSSMSSEAAGTSLDNLSSIVNSI 216 Florida lancelet
XP_005990556 152 EHY---SGESDASSPRSnCSDGMmDYSGPPCSSRRGS-----Sy-gSSYFTETPN--DSRNGKNSVISSLDCLSSIVERI 220 coelacanth
XP_003773606 188 EHY---SGDSDASSPRSnCSDGMmDYSGPLCSSRHRN-----Gy-dSSYYSDSPS--DNKPGKGLVVSSLDCLSSIVERI 256 Tasmanian devil
Q7YS82       191 EHY---SGDSDASSPRSnCSDGMmDYSGPPSGARRRN-----Cy-dRTYYSEAPN--EPRPGKSAAVSSLDCLSSIVERI 259 cattle
Q90477       151 EHY---SGDSDASSPRSnCSDGMmDFMGPTCQTRRRN-----Sy-dSSYFNDTPNa-DARNNKNSVVSSLDCLSSIVERI 220 zebrafish
XP_004069479 177 EHY---SGDSDASSPRSnCSDGMtDFNGPRCQTTQKGs----Yd-gGSYFSEALNg-GHRNDRSSVVSSLDCLSSIVERI 247 Japanese medaka
Q7Z1G3       139 ENSsgeVSDSSAPSPGS-CSDGM-AAHSPHSFCTDTSgnsswEhgdRHHGNGHEN-----QSCGNNVSSLDCLSLIVQSI 211 Florida lancelet
XP_002604824 141 ENSagqSADSPAASPGA-CSDGM-SANSPDSVWSDTSgtfqgEdnmASFGCDDVT------ASWNSASCLDSLSLVVQNI 212 Florida lancelet
ADA84034     158 EHY---GSDSGTSSPHSnCSDGLvDFISPSSARSENS-----D---ASYCSQTAEdcSSSSSKTSVISSLDCLSSIVERI 226 Nile tilapia
XP_005812899 161 ERY---GGESDSSSPQSsCSDSMmDFISPCSASSENG-----N---TSCGKQTADgcSSSSSKSSLISSLDCLSSIVERI 229 southern platyfish
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