3CW1


Conserved Protein Domain Family
U1snRNP70_N

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pfam12220: U1snRNP70_N 
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U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
This domain is found in eukaryotes. This domain is about 90 amino acids in length. This domain is found associated with pfam00076. This domain is part of U1 snRNP, which is the pre-mRNA binding protein of the penta-snRNP spliceosome complex. It extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition.
Statistics
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PSSM-Id: 403437
View PSSM: pfam12220
Aligned: 131 rows
Threshold Bit Score: 31.7738
Threshold Setting Gi: 74997505
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3CW1_K           3 QFLPPNLLALFAPRDpIPYLPPLEKLPHeKHHnQP-YCGIAPYI--REFeDPRDAPPPTRAETR--EERMERKRREKIER 77  human
CAR27077         6 SKFPSDVSRLFKPRPpLEYKRPVDYPPEkRQTcpH-ITGVSQLLg-EQL-SSYVNQFPQGSDNK--YLQKYEEASHAKDN 80  Zygosaccharom...
XP_003683264     6 TKFPADVSRLFKPRPpLAYKKPVDYPLEkRQTcpH-ITGVSQILd-KPL-AGYLSDFPQGSQNK--YLQDYEKAADSKNR 80  Torulaspora d...
CAR21212         2 iKFPQNVSKLFRPGPpLQYKKPVDYPVEeRKT-ANkIQSLSGYL--GAL-DTYRSEHPEGSENG--HLDAYNAAENARQV 75  Lachancea the...
Q75AJ0           6 SKFPDRVSSLFKPRPpLQYRKPVDYAPEeRKTa--tITPVSSVLgtDAL-MRYMQEFPTGSENL--LIQRYEELKTINSR 80  Eremothecium ...
ybcl:Ecym_4324   6 SKFPERVSKLFNPRPpLQYKKPVDYPPEkRRTh--fIAPLSSLVfsDTL-VRYMQEHPQGSENR--HLDKYEEVRSLTAR 80  Eremothecium ...
CCK72778         2 SKFPPDVAELFSRGPpLPYRKPIDYPLEkRRTnpN-ITGLTKYL--SSL-HQYKEEFPRGTANK--HLRVYEDVKHEKEK 75  Kazachstania ...
CCF60705         6 SKFPSDVTRLFKPNPpLPYKRPSDYPEEqRRTnpN-ITPVSNYL--AQL-TDYINEYSDGTPNK--HLEAYEEIRTSQLQ 79  Kazachstania ...
XP_003676755     6 SKLPSDISHLFKPGPpLRYFKSTDYPPSkRQTnpN-ITGVSQFLs-NNL-QSYLNDFPSDSQTKvdEDKQFEEVEKERI- 81  Naumovozyma c...
CCD25303        11 SKISSDISTIFKPRPpLRHFKPTDYPVHrRRTnpN-ITGISKYIn-SHL-LSYVKEYSTTTTTN--SEVTENNEVVLGNK 85  Naumovozyma d...
3CW1_K          78 RQQEVETELKMWDPHN 93  human
CAR27077        81 EYAKLNQETRGWEPHK 96  Zygosaccharomyces rouxii
XP_003683264    81 EQRELENKLSEWDPQN 96  Torulaspora delbrueckii
CAR21212        76 EAKALNAKLAIWNPDE 91  Lachancea thermotolerans CBS 6340
Q75AJ0          81 KEQELEEELAKWAPEN 96  Eremothecium gossypii
ybcl:Ecym_4324  81 NERLLEAEQAKWVPEE 96  Eremothecium cymbalariae DBVPG#7215
CCK72778        76 EMDKLQLLCEEWKPAE 91  Kazachstania naganishii CBS 8797
CCF60705        80 NLEYLHNELQKWDPMN 95  Kazachstania africana CBS 2517
XP_003676755    82 --SKMNESIRNWDPHN 95  Naumovozyma castellii CBS 4309
CCD25303        86 IAQENKEALDKWNPHE 101 Naumovozyma dairenensis CBS 421
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