pfam12220: U1snRNP70_N (This model is not part of the current CDD release)
U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
This domain is found in eukaryotes. This domain is about 90 amino acids in length. This domain is found associated with pfam00076. This domain is part of U1 snRNP, which is the pre-mRNA binding protein of the penta-snRNP spliceosome complex. It extends over a distance of 180 A from its RNA binding domain, wraps around the core domain of U1 snRNP consisting of the seven Sm proteins and finally contacts U1-C, which is crucial for 5'-splice-site recognition.
Jiyao W et al.(2023). "The conserved domain database in 2023.",