Conserved Protein Domain Family
m04gp34like

?
pfam12216: m04gp34like 
Immune evasion protein
This protein is found in archaea and viruses. Proteins in this family are typically between 265 to 342 amino acids in length. The proteins in this family are or are related to the m04 encoded protein gp34 of pathogenic microorganisms such as murine cytomegalovirus. m06 and m152 genes are expressed earlier in the intracellular replication phases of these microorganism' life cycles. They function to inhibit MHC-1 loading and export. gp34 is theorized to prevent immune reactions from NK cells which would ordinarily recognize and attack cells lacking MHC.
Statistics
?
PSSM-Id: 371968
View PSSM: pfam12216
Aligned: 11 rows
Threshold Bit Score: 183.459
Threshold Setting Gi: 157676113
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ABM74002   8 CTVMWR----------------------SVIVFLLF-SSWLTTSGDSSHRSrrpplqspksgittwiggSSrt-rFPSts 63  Murine cytomegalovirus
ABM74000   7 SSPSVR----------------------TYLRSTRLlLLFVFCVVISYAQE------------------CPnydgRNQ-- 44  Murine cytomegalovirus
ABM74034   1 MSLASH----------------------LPLVALFFlPY-ILLIYASSNDQ------------------CK-----DDkv 34  Murine cytomegalovirus
ABM74013   1 MSPVYR----------------------LVLISVLM-SN-IFSSADANAND------------------CQ----EMEkk 34  Murine cytomegalovirus
ABM74008   1 MSLGCR----------------------LMLVMVFVlS--ILHISTQNKNE------------------CE----KLMke 34  Murine cytomegalovirus
CAJ86507   1 MSLVCR----------------------LVLVTVVL-SSLFTFAISRNDNE------------------CE----KMQke 35  Murine cytomegalovi...
ABM74045   1 MSLTHR----------------------PLLVIVVV-SVVISFVGSD-KDQ------------------CQ----KDDea 34  Murine cytomegalovirus
CAJ86508  19 RSRPVQllalvtvlasmtfqmgeslipiIPDFSSFMmNPLPMPQIMPPSTNetketkesyvkteepivgCNvsrtEINrl 98  Murine cytomegalovi...
ABM74014   2 QRLAFS-------------------------VMRLLlSGILLSSPLTSER-------------------------INDat 31  Murine cytomegalovirus
CAP08055   3 HRYLGR----------------------SLFILVIYfVALSISRVTPAAR-------------------APapktNNCtk 41  Murine cytomegalovi...
ABM74011   6 SSCASRpr------------------gvCRLRVLLLvCAAVVPVVSSAPLp----------------------------- 38  Murine cytomegalovirus
ABM74002  64 fgtYKTVALGgdkcspwkytSKCFNsKDATrflKKSVNP--KTGDKTFTCMPAE--NVYANASWRIEWIL-GNGTTWLTP 138 Murine cytomegalovirus
ABM74000  45 ---HESVWKYrk-------eLGCLY-RRIT---NITLYD--NNGIKTAYFTLPGpaAVYVNASWTFEWFI-KPLFASVDA 107 Murine cytomegalovirus
ABM74034  35 lkeLLS-RRP----------VGCWYkRAT----TTISTS--GSE-TILSCTLP---NVYVNATWYTEWIM-ESISASAHM 92  Murine cytomegalovirus
ABM74013  35 ykeKMKYRRP----------LGCYFkSITP---TQTSSS--SSE-RILKCTLP---SVKVNASWSVEWVV-VSLDSSLDV 94  Murine cytomegalovirus
ABM74008  35 sreRMKYRRP----------LDCYFkRIDP---SKTTTE--GTDGTTLTCTLP---VVQVNASWEVEWVV-EKLHASVDT 95  Murine cytomegalovirus
CAJ86507  36 ykeKMKYRHS----------LGCYFkGINP---TKVPSS--DPR-TILKCTLP---DVKVNASWTLEWVV-VNLHTSVDV 95  Murine cytomegalovi...
ABM74045  35 fkkKMQYRHP----------LGCYFkGITP---TKIPSK--GD--TLLTCKLP---DVKVNASWTLEWVV-VKLQNSVDV 93  Murine cytomegalovirus
CAJ86508  99 knqMKKIPNT----------FKCFKkDGVR---TSLDMQ--TTGEKRFACEIPN--NVYVNATWYVHWVV-GKIAASVSP 160 Murine cytomegalovi...
ABM74014  32 flaNPNRALIwp------nlAKCFDtKDATrflKKSVNT--KTGEKIFTCMPTI--SVYANATWSIEWVL-GDWTTWLSE 100 Murine cytomegalovirus
CAP08055  42 fsyPGVSP------------GYCTErRDM----KLITKF--KNGTKVFSCPLLT--DICVNARMSGVWCVnNSAIGS--- 98  Murine cytomegalovi...
ABM74011  39 -------------------gYYCYAkNATErrtPNIDRDywRPGVSVFGCRMPK--GVCIEGEWTIEWYI-PSLQASVIN 96  Murine cytomegalovirus
ABM74002 139 AIRFVSTDRSPPTfNGTLSVAYSSRLVYTdennNTNS-NKTGLRVDKSg-------LHISSAVRAdlV---KDVHDVKCI 207 Murine cytomegalovirus
ABM74000 108 AGYYTSSTTSVAK-SDKNTVHIFSYYDPYsgrlKKTVgLKDGFKADPSg------nLYIFQNASVagN---ITVNDTICV 177 Murine cytomegalovirus
ABM74034  93 RSYYVSSTSSHPTfNKTEVLYVYRGNSLR----TKIVgPKDGFRVNDSng-----nLHIYPNAS---Y---SDTGSVICH 157 Murine cytomegalovirus
ABM74013  95 VSYYESSPTSEPKfLYTTWNYTPLDYK------KKLLtIDNGFKVDNSsnsenrgnLYVYSNAT-------DHAGSVKCR 161 Murine cytomegalovirus
ABM74008  96 VGYYESSPSSGPKfKRTYFNYTPMNGLSKrykaNTPVgVKNGFRVDNSsts--ggnLHVYSNAT---E---GSVDSIKCR 167 Murine cytomegalovirus
CAJ86507  96 TSYYESSPNSEPRfLRAILNFTPMHGLRT----KNLLkVKDGFQVDNStdngnggnLYVYPNAT---T---GSADSVRCR 165 Murine cytomegalovi...
ABM74045  94 TSYYESSPNSGPRfLRAILNFTPIQGLRT----KSLLtFKNGFQVDNStdngnggnLYVYPNAT---T---GSADSVRCR 163 Murine cytomegalovirus
CAJ86508 161 IVYFTSTTSSPPTlDGNMHPFYR----------RKIVtAANGFKVDEKtg-----dITVARSNA-------SLADSVRCR 218 Murine cytomegalovi...
ABM74014 101 ISRFMSTEHSPPKfVHTVPGIYWSRMMYId-------sNNTDFKIDKDg------aLLVSPDVVRd-----DLAQGVRCL 162 Murine cytomegalovirus
CAP08055  99 -LFFTSTSHTPPMfHGFTPTHHR---------------RLSGLWVDYQtg-----yLYVYPNATK------KPEKEIYCT 151 Murine cytomegalovi...
ABM74011  97 QVFFKSQTWLGPSmQYIIPSYERGKEVT----------CKQGFCVDRAeg-----nLIITDDDKRkeEwarKPTRDVVCK 161 Murine cytomegalovirus
ABM74002 208 LSVCLW--TDRISVYnTSDgyiethvevDSTAVANLSIIATLDDFVYPLGYPmeytKK-----SAYSWPSETSQPQMS-- 278 Murine cytomegalovirus
ABM74000 178 LRLCLW--TTKDSTI-SID---------DVGIKNNLSSILSLPTYDEIRGVL----YMr----PQYNYSIPIKRIVQRs- 236 Murine cytomegalovirus
ABM74034 158 LLVCAW--RYNENSC-------------KEDIFKNLSNVLSLPDYGVPSTE-----RSr----YDYDSTKKSPP-DVT-- 210 Murine cytomegalovirus
ABM74013 162 LKMCPW--TSDSSMN--TP---------DKDLLTKMQNVLTLPDYIAPIADP----GPk----YDY-YAKKTPPADMT-- 217 Murine cytomegalovirus
ABM74008 168 LKMCPW--TSDEKMK--TP---------DEAMLKKMNEVLKLPNYGVPELEP----EPr----FEYDYTKKESP-DVT-- 223 Murine cytomegalovirus
CAJ86507 166 LRMCPW--TSNSKMT--AP---------DEEMLRKMSEVLNLPNYGVPDLTP----PRr----DEF-YTKNESP-NTI-- 220 Murine cytomegalovi...
ABM74045 164 LRMCPW--TSNSKMT--AP---------DEEMLRKMSEVLNLPNYGVPDLTP----PRr----DES-YTK--TP-NTT-- 216 Murine cytomegalovirus
CAJ86508 219 LIVCLW--TKNDSISdLPD---------DDPQMKNMSGVIKLPDYSGPDTLL----T------VPFDYAAWRQRMRTEme 277 Murine cytomegalovi...
ABM74014 163 LRVCLW--HDKDVNF-------------DPVAVTNLSVVEALDDFIYPIEYPvrrgIDk----NAYRWPSETKRGESMs- 222 Murine cytomegalovirus
CAP08055 152 LTICITaiTTRRPTTtRS----------SRGVSTGISTTGLWTDETS----------------VVFPFVSAGENFGVSas 205 Murine cytomegalovi...
ABM74011 162 LTACLR--ATSVSLSsRTT---------YEECNGTLEDYLSLPDFENIYDISkvvpYVpppkaPAVPPKVPGKAEDAPpd 230 Murine cytomegalovirus
ABM74002 279 --------MSVFFGILSVYIVLIIGEVyICLKCHYN-------------HKHKSAADVAVEY 319 Murine cytomegalovirus
ABM74000 237 -------nDAGLVAAILFFIAAIFVAV-LLLGYSYKpt----------lFRRISTLIHGQQL 280 Murine cytomegalovirus
ABM74034 211 ------------VTALSVIVTLLYVAAfCVLAYVFGps----------lCRRFFTNDCCSTF 250 Murine cytomegalovirus
ABM74013 218 ------------VTTLTVIVTLLYVVAfCLLAYVFGps----------lYRRFFSSDCCSNF 257 Murine cytomegalovirus
ABM74008 224 ------------VTALTVIVTFLFVGLlLVLIYLYGps----------lYRRFFSSDCCSNF 263 Murine cytomegalovirus
CAJ86507 221 ------------VTTLTVIVTLLFVGLlLVLIYLYGps----------lYRRFFSNDCCSNF 260 Murine cytomegalovirus (strain K181)
ABM74045 217 ------------VTTLTVIVTLLYVVAfCLLAYVFGps----------lYRRFFSSDCCSNF 256 Murine cytomegalovirus
CAJ86508 278 ep---srrRRQLLLVISVIASLLWLAVgAMLFYTYGrepl------arlLKRYGKRLAAVRI 330 Murine cytomegalovirus (strain K181)
ABM74014 223 --------MGTFFGILTAEVVLAIVVHiAVry----------------yRNRQQDFDNTVEY 260 Murine cytomegalovirus
CAP08055 206 ------pqTASSGTIAAIVIVIVICVGlVVLAVLYYrgyighsrrlnlyRERLRARFLVSHS 261 Murine cytomegalovirus (strain K181)
ABM74011 231 escigcdnPGLNAAAIAVPVVTVIVLVsGIgy----------------lCRSTESRQRTLEL 276 Murine cytomegalovirus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap