Conserved Protein Domain Family
Glyco_hydr_116N

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pfam12215: Glyco_hydr_116N (This model is not part of the current CDD release)
beta-glucosidase 2, glycosyl-hydrolase family 116 N-term
This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 320 to 354 amino acids in length. This domain is found associated with pfam04685. It is found just after the extreme N terminus. The N-terminal is thought to be the luminal domain while the C terminal is the cytosolic domain. The catalytic domain of GBA-2 is unknown. The primary catabolic pathway for glucosylceramide is catalysis by the lysosomal enzyme glucocerebrosidase. In higher eukaryotes, glucosylceramide is the precursor of glycosphingolipids, a complex group of ubiquitous membrane lipids. Mutations in the human protein cause motor-neurone defects in hereditary spastic paraplegia. The catalytic nucleophile, is a glutamine residue in the downstream family pfam04685.
Statistics
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PSSM-Id: 520136
Aligned: 103 rows
Threshold Bit Score: 150.129
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54D71         433 GVPIGGIGSGSINRGWKGDFVRWNL-------------------------------------NNGLVS--NEIVdvdkFS 473  Dictyosteliu...
10_pfamImport    1 AFLLGGIGTGNVSVGARGELRSWQIfnepgqf---------------------------------------nflpytfFA 41  
CDF06518        27 DFLLGGIGTGNVSLGARGNLTTWQIfnqpgqm---------------------------------------nrmpytfFS 67  
CDC03583        19 KFLLGGIGTGNVSVGTRGNYCDWEIfgqpgkg---------------------------------------ihfpytfFA 59  
CDC04102        21 RFLLGGIGTGNISLNARGELCDFEIfnrqskg---------------------------------------lklpysfFT 61  
WP_022307398    39 AFPVGGIGTGMICFEGTGAISHVSLhhvpdl-----------------------------------------fhepctFA 77   Alistipes sp...
Q8A3P6          48 AFPIGGIGTGMYCLEGTGYISHMSVwhrpev-----------------------------------------fhepgmFA 86   Bacteroides ...
WP_008582250    67 AFPIGGLGAGMFCLEGSGAVSHMSInnhpei-----------------------------------------ffepniFA 105  Niabella soli
WP_016482313    20 AMPVGGIGTGFFALGGRGQLTEWQLmsrpnrg---------------------------------------wrppyahLL 60   Chthonomonas...
WP_008583881    69 GMPVGGINAGGMYLSGDGRLWLWDVfnlnqeginpvdipwktsvqgelrkvrsrdggsyiapPKAKELrpLDQG----FA 144  Niabella soli
Q54D71         474 VYINfdnSntsssssssssnsstpppqfsnnnnnsynnsynnninnngfdnnlkSKQKAVVLYPgkpksnlnLDVWNwgl 553  Dictyosteliu...
10_pfamImport   42 LRAEvegG-----------------------------------------------EAVSKILES---------------- 58  
CDF06518        68 IWMKqdgG-----------------------------------------------EAISRVLES---------------- 84  
CDC03583        60 LWAKsknT-----------------------------------------------QPIVRILES---------------- 76  
CDC04102        62 LWYSlpsG-----------------------------------------------ESDALVLEA---------------- 78  
WP_022307398    78 AVCVkg------------------------------------------------vENGAKVLEAn-------VPEYK--- 99   Alistipes sp...
Q8A3P6          87 ALYVkg------------------------------------------------vCNGAKVLEGp-------VSDWR--- 108  Bacteroides ...
WP_008582250   106 AIAIkg------------------------------------------------aQPMAKVLEGp-------VPEWK--- 127  Niabella soli
WP_016482313    61 LRTQrnvGt--------------------------------------------kEEIKLRVLEA---------------- 80   Chthonomonas...
WP_008583881   145 LKLEye------------------------------------------------gKEQTRQLRE---------------- 160  Niabella soli
Q54D71         554 KGD---------------------NSCYFGLFPRAWTVYEeP-HPDIRLTCKQVSPVIPHNYQESSYPCGVYVWKIEnNN 611  Dictyosteliu...
10_pfamImport   59 KLNppfthpegtlrcelgglprfeKSTMSAEYPFVRVKLEdK-QVPVQVEMEAFTPFIPLNADDSGIPGAYLNYRVK-NP 136 
CDF06518        85 KLNppfnrsqgffrnevaglprfdSSVMTTKYPFVNIEFQdE-EIPVQISLEAYTPFIPLNAKDSGIPGAYLNYKVK-NT 162 
CDC03583        77 RIQppytcshgfisadlaglprfeRSSFSAAYPFVNVALEdS-KLPLSVELEAFTPFIPLNAKDSGIPGAVIRYKVK-NN 154 
CDC04102        79 KPQglcdapmgvapslvpglprfdSSCFSSAYPFANIQLKkD-GLPFEVTLQAYTPFIPLDDVNSGIPGIRFVYRLK-NL 156 
WP_022307398   100 -KYgrlnggmgvg-gttwglprfdEGRFSARFPFARLDLHdD-DLPLDVSIVAWNPFIPNDEDNSGLPVGGFEYTFR-NT 175  Alistipes sp...
Q8A3P6         109 -KFgmpnygtggsmgsilglprfdTVEFEARFPFAKVSLTdK-DIPVKVTILGWSPFIPGDPDNSSLPVGGLEYSLE-NT 185  Bacteroides ...
WP_008582250   128 -IFgqrgtgngas-gtnyglprfdNASFLARFPFGTIELKdN-EMPMDVAINGWSPFIPGDEDNSGIPVGALEYTFA-NR 203  Niabella soli
WP_016482313    81 -ASdtdlgadfgapgtlmgvarfpRARFEAAYPFGRVILEdKsDVPVRATIEAFNPLIPNDTPNSSLPFGLLTITLT-NM 158  Chthonomonas...
WP_008583881   161 --Edw------------------dEVRFEATYPVATITYSsK-DIPVQAVLQAYSPFIPLDTDRSGLPVSVFTITIK-NA 218  Niabella soli
Q54D71         612 QYSSADVSLMLTWQ--NSIGT----------------QSDQDGGHFNKYFTFGDndqqspssssssssgnnkknIKG--I 671  Dictyosteliu...
10_pfamImport  137 TNQPVTVSIAGSLA--NAVGFekyd---------iwnHMKLNGNPVNEYQERNG--------------------LKG--L 183 
CDF06518       163 TKENIEISIAGSMN--NAVGFegyn---------nfsFMKHAGDRENEYRSDDV--------------------IRG--I 209 
CDC03583       155 SGEALEATVASSVA--NAVGFngyd---------lfdNLLVKKPVKNQYLDQDQ--------------------MKG--L 201 
CDC04102       157 LDQPVKAAVSATMP--NACGFdsfst-------dglnKLYLKGRPENRVVKKNG--------------------LQG--- 204 
WP_022307398   176 SKK--PVVAVFSFNtrNFMYKtdaavssvtpfergfiLNQEAPANER--------------------------------- 220  Alistipes sp...
Q8A3P6         186 SKE--VQETIFSYHarNFLSWgkgldaik-tmphgfiLSQSGTETEP--------------------------------- 229  Bacteroides ...
WP_008582250   204 SSK--TVEAVFSYNakNFVARgekagir--klengfiLSQGQGKDKP--------------------------------- 246  Niabella soli
WP_016482313   159 TPLPVRATLTLLMT--NIIGTd--------------gMVSDLKDNVTETAEVVG--------------------WHG--M 200  Chthonomonas...
WP_008583881   219 GKHPVKATLAGWLE--NKAALh--------------tAAVNRLGRKNTTFKEEQ--------------------ITGvyS 262  Niabella soli
Q54D71         672 TMIHKKEQKctlpngntkvFNDPMEYSIA-----------VM-------DEP-----D---VEISFcerfettsrldaan 725  Dictyosteliu...
10_pfamImport  184 FFRGENVPEk---------HIANGTMCLA-----------TSedd--vtAKPlwfqgEw-tDGAQD-------------- 226 
CDF06518       210 MYTGKNFSDk---------HITWGNMALS-----------TTekeeyitKKPlwyqgQw-tDGGED-------------- 254 
CDC03583       202 LYTSPELAEd---------DFTNGSIAVM-----------TGeds--vtVKEewlsgAw-wDGIHD-------------- 244 
CDC04102       205 ICYSTDLEKe---------QLGFGTMALL-----------TDeqe-gfsAKPrwlneGw-wDGAEE-------------- 248 
WP_022307398   221 --------------------HLEGHLAIW-----------TDda---rtTVDhcwfrGgwfDPLTM-------------- 252  Alistipes sp...
Q8A3P6         230 --------------------HLQGDFAIF-----------TDqd---slKINycwfrGgwfDSLTM-------------- 261  Bacteroides ...
WP_008582250   247 --------------------FTQTDFAIY-----------TTane--qpVVDycwfrGgwfDPVTM-------------- 279  Niabella soli
WP_016482313   201 KFYKARELR----------TAQNGTMAFL-----------TDaqe--ihVARrwpfqGspwNGEALg------------- 244  Chthonomonas...
WP_008583881   263 TLEKTAFGNqqa-----dkSFDYGTLCLAaldrdavaiadIEai------------------------------------ 301  Niabella soli
Q54D71         726 LWYTFNKKGEL-------ENNKDSRPSAPKKP-I----GAAVA-AKVKVAAGSSKTIVFCISWDAPITRFQMGSA----- 787  Dictyosteliu...
10_pfamImport  227 FWDDFISDGSLdvdsgkvQEGCAIAKIYDFSYlHfsdsIGSIC-IKKVLKPGEERVFPFLLTWNFPNRVRDWGDTdkhvk 305 
CDF06518       255 FWQDFSTDGRLnnesiydQVGSNWAEKSDFSFlHftdkIGSLC-ITQTLKPGEEKVFPFILSWYFPNRPKMWIELdkdkq 333 
CDC03583       245 FWDDFSEDGRLefhsefqGKESKFNDLSDLr-------IGSLG-VRKTIPAYGEAVFEFILTWYFPNRPKYWGGHvcpen 316 
CDC04102       249 YWQDLMEDGCLg------EAVSGGKPVSRINPsGeesaIGSIA-VQKVLQPGESKDFVFYLTWHFPNR-YGWWPDghdar 320 
WP_022307398   253 AWNNV-TRGEL---------------ISNEPG-Pga-pGGSLY-VPVELAPGESKTVRLYMAWFVPRSNHRIGLDpknvr 313  Alistipes sp...
Q8A3P6         262 VWNAI-EAGLM---------------PQCPAI-EkgapGASMF-VPVTLMPGEKKTIRIYTAWYVPNSTLRLGEEpedwn 323  Bacteroides ...
WP_008582250   280 IWNTI-ADGKV---------------SNTPPV-AadapGASLF-VPFKLAPGAKKIIRVMMAWYVPESDLSIQDKgpdgk 341  Niabella soli
WP_016482313   245 IIDSLLQTGWL---------PDADPNAPCPPS-PndtwHSSLTmIVPPLAPNKSQTVHLLIAWHFPLRNLQEEGWwspea 314  Chthonomonas...
WP_008583881   302 ------dNARL---------FTSTTKVDQAVKaAqqtlTGSVI-TTVTAAANESATVSYIISWHTPNLMIGDGKVlp--- 362  Niabella soli
Q54D71         788 --------------------------YY-KRYTKFYgnqggNSQRIAYDAINNWKHW 817  Dictyostelium discoideum AX4
10_pfamImport  306 av------------------qeyhyeIVgNYYSTLFq----DAWTVADYM--NQKKE 338 
CDF06518       334 di------------------vdgnydVTkNYYATLFe----DAWNVASYLAGNADRL 368 
CDC03583       317 ---------------------rnkkeIEhNYYAGFQk----NAWDYGVYLYKNLESL 348 
CDC04102       321 k-------------------pipcadIYqNYYSTLWd----DALAVAGYFHANQTRL 354 
WP_022307398   314 dfgscy----------neadyagqpdRYePWYSRRFr----NVNEVAAYWEENYDQL 356  Alistipes sp. CAG:268
Q8A3P6         324 dnnvds---------arlavekadkgNYkPWYSSRFt----GVNEVIDYFLSHYKIL 367  Bacteroides thetaiotaomicron
WP_008582250   342 enchsaaccitpadsgleeypkftgnKYkPWYAAKFk----NLEAVVDYWTREYDSL 394  Niabella soli
WP_016482313   315 ----------------------gqdpIQtNWYATQFq----DALDVARRVIPHLPDL 345  Chthonomonas calidirosea
WP_008583881   363 ------------------------ekDRgQYYDNQFk----NAKEVASYVAANFKEL 391  Niabella soli
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