6BJC


Conserved Protein Domain Family
TPX2_importin
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pfam12214: TPX2_importin (This model is not part of the current CDD release)
Cell cycle regulated microtubule associated protein
This domain is found in eukaryotes. This domain is typically between 127 to 182 amino acids in length. This domain is found associated with pfam06886. This domain is found in the protein TPX2 (a.k.a p100) which is involved in cell cycling. It is only expressed between the start of the S phase and completion of cytokinesis. The microtubule-associated protein TPX2 has been reported to be crucial for mitotic spindle formation. This domain is close to the C terminal of TPX2. The protein importin alpha regulates the activity of TPX2 by binding to the nuclear localisation signal in this domain.
Links
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Statistics
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PSSM-Id: 520135
Aligned: 26 rows
Threshold Bit Score: 118.984
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6BJC_T       367 PQTPVLQTKHRARAVTCKSTAELEAEELEKLQqyKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERES 446 human
ERN19493     318 PREPELETAQRARRIMIKKNSDAGEGMLLMAP--KFKARPLNRKIFEAPSVPLPQKSIPRVPEFREFHLKTTERAIQHAA 395
Q4V3B0       249 PQEPDFATSHRANRIRHKNDAKLEQD-STSVY--RFKARPLNRKIFEAPSLPIRKNSTPKLPEFQEFRLKTSERAMQHSS 325 thale cress
NP_001078430 249 PQEPDFATSQRAHRIRHKNDAKLEQE-QPAVY--RFKARPFNRKIFDAPSLPIRKKSTPKLPEFQEFHLKTSERAMQHSS 325
5_pfamImport   6 PHGADFVTSQRALRIRQKNDAKLEQD-STAVY--KFKARPLNRKIFDAPSLPIRKKSTPKLTEFQEFHLKTSERAMQHSS 82 
KRH77444     251 PREPDLETAHRAQRIRPKIAAEAEVV-TVAAP--IFRARPLNRKILNAPSLPLPKRSTPRLPEFQEFHLKTQERAMQHTS 327
XP_002509646 248 PREPDLETAHRAHRMRPKNNTEVEHV-TVAAQ--RFKARPLNRKILEAPSLPLPKKSTPKLPEFQEFHLKTLERAMQHAF 324
XP_002303544 259 PREPDLETAHRAQRTRPKDSIEQQHM-TAPAR--RFKARPLNRKILEAPSLPLPKKSTPKLPEFQEFHLKTLERAMQHTS 335
CBI34799     258 PREPNLETAYRTQRMRSKHHTEVDQV-ALNVH--RFKARPLNRKILEAPSLPLPKKSTPRLPEFQEFHLKTSERARQHTT 334
XP_003550895 265 PREPDLRTARRAHRIRPKNVGEAEHV-TVAAP--KFKARPLNRKILEAPSMLPPKRSTPRLPEFQEFHLKTFERAMQHTS 341 soybean

6BJC_T       447 KKKTe----------------------------------------------De----hFEFHSRPCPTKILE--DVVGVP 474 human
ERN19493     396 AAPSlpshvdsnnvankhkhassnqvgtidlkmschqaphlekhkvvdepkQeqreriATFKARPLNPKILSskGDIGMF 475
Q4V3B0       326 AVSTssyqgnnnhkeadkpnrtf----------pdgvnreprrqraidipkDdv--rkDLFKARPLNKKILSsgREIGMF 393 thale cress
NP_001078430 326 AVTTrshaykesdksiitdml-------------dgdnresrrpsgmdiskHdvsegsHVFKARPLNKKILSsrGDMGIF 392
5_pfamImport  83 QVTKrsnqwnhaykgpdksnitd---------vfdgvsmesrrpsgmdiskHdvsegkHVFKARPLNKKFPD-------- 145
KRH77444     328 ATSTsslhcndsdkdldkhravs---------aqenrirdlrrpsamgapkHdgldfaHSFKARPLNKKILSskGDIGVF 398
XP_002509646 325 VVSSsslqhndseqgldksttvs---------vaeigkresrrpstvdtkkQdgcsapHVFKARPLNKKIFTskGDIGVF 395
XP_002303544 336 SVPSslfqcndldkgldkpstis---------vaenvktesrrpttmdapkQdgccatHIFKARPLNKKIFSskGEMGVF 406
CBI34799     335 GSSSslhcndpdkglqkpstnsv----------pengnkdlrrpnttdapkQdacetvRTFKARPLNKKIFSskGDIGVF 404
XP_003550895 342 AMSSsfhyddsdkgwdkhtsvsa----------lenrikdlrrpaaaaaptNdglgftHIFKAQPLNKKILPskGNGGVF 411 soybean

6BJC_T       475 EKKVLPITVPKSPAF 489 human
ERN19493     476 KNCKREATKPTEFSF 490
Q4V3B0       394 TKSKRETTAPLGFSF 408 thale cress
NP_001078430 393 KNSKRETTVPLEFSF 407
5_pfamImport 146 KDETDSEMATQEFNF 160
KRH77444     399 RNRKQETTVPMEFNF 413
XP_002509646 396 RNSKRETTVPTEFNF 410
XP_002303544 407 RNSKRETTVPMEFNF 421
CBI34799     405 RNSKRETTVPLEFNF 419
XP_003550895 412 HNSKQETTVPMEFDL 426 soybean
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