7PFO


Conserved Protein Domain Family
Dpoe2NT
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pfam12213: Dpoe2NT (This model is not part of the current CDD release)
DNA polymerases epsilon N terminal
This domain is found in eukaryotes, and is approximately 70 amino acids in length. The family is found in association with pfam04042. There is a single completely conserved residue F that may be functionally important. This domain is the N terminal domain of DNA polymerase epsilon subunit B. It forms a primarily alpha helical structure in which four helices are arranged in two hairpins with connecting loops containing beta strands which form a short parallel sheet. DNA polymerase epsilon is required in DNA replication for synthesis of the leading strand. This domain has close structural relation to AAA+ protein C terminal domains.
Links
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Statistics
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PSSM-Id: 520134
Aligned: 7 rows
Threshold Bit Score: 102.543
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7PFO_A         2 APERLRSRALSAFKLRGLLLRGEAIKYLTEALQSISELELEDKLEKIINAVEKQPLSSNMIERSVVEAAVQEC 74  human
1_pfamImport   1 AGRRIKSRVSAAFKMRGLVLRPEASKYLVEVLESVGPSELEDVIEKVLDAVEKQPLSSNMIELSVVESAVQDC 73 
A7YWS7         2 APERLRSRALSAFKLRGLMLRGEAVKYLTEALQSINEIELEDALEKIIDAVEKQPLSSNMIERSVVEAAVQEC 74  domestic cattle
XP_001632217   1 MADPLRKKVLSTFRLNGLSLQSDATKYLRDVLVPLSEPEIEDWLEKIVETVQKQPLSSTLVDREVVETAVQEC 73 
Q19196         6 EENALRREIVKTFQIHAFELKKEAVKLCVKLFLDHDKETRKKWTNKMIELLKKQTLQSSLISEELIRDTFRQC 78  Caenorhabditis elegans
XP_033238249   4 ELIPLRKRITNNFKLCGFLIRSENSTYLAEQLLPFDADERDKWLTVITENLQGQKLATPHVERAALEKAINEL 76 
Q5ZKQ6         2 EPERLRRRLGSAFRVRGLLLRAEAVKYLTETLESLNEEEFEDVIDKIIDAVEKQPLSTNMIELSTVEAAVQEC 74  chicken
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