Conserved Protein Domain Family
HDAC4_Gln
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pfam12203: HDAC4_Gln 
Glutamine rich N terminal domain of histone deacetylase 4
This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.
Links
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Statistics
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PSSM-Id: 403429
Aligned: 10 rows
Threshold Bit Score: 35.6005
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005472509   66 SDPGLWERQLQQELLLIQKQQQIQKQLLISEFQKQHEKLTRQHQAQLQEHLKL----QQELQA---------MKQQQElA 132 
CAG05956        2 VDTTMREQQLQQELVLLKQQQELQKQMLFAEFQKKHEVLTRQHEVQLQEHLKQ----QQELLA---------AKRQQE-L 67  
XP_020024032   67 VDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ----QQEMLA---------AKRQQE-L 132 
1_pfamImport    1 VDPLFREQQLQHELLILKQQQQMQKQLLFAEFQKQHEHLTRQHEVQLQEHIKQiaspHQIFHVvymcplssfMKRQQE-L 79  
XP_008565362   59 VDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKL----QQELLA---------IKQQQElL 125 
AAQ97977       37 SEVTVWERQLQQELLLIQKQQQIQKQLLITEFQKQHENLVRQHQAQIQEHLKL----QQELHV---------MKQQQEqL 103 
XP_022531068   65 VDSSLQDQQLQQELLSLKHKQQVQRQLLIAEFQRQHEQLSRQHEAQLQEHIKH----QQDLLA---------LQHQQElL 131 
XP_021565298   63 EPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQ----QEMLAM---------KHQQELlE 129 
2_pfamImport    1 AEPALREQQLQQELLALKQKQQLQRQILIAEFQRQHEQLSRQHEAQLHEHVKQ----NEKL------------THEQTrC 64  
XP_021565298   62 AEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQ----QQEMLA---------MKHQQElL 128 

XP_005472509  133 EKERRLEQQqqqqsQQEkEQEKHRREHHI 161 
CAG05956       68 EQKRKLEQQ-----RHE-EQEKHRLEQQL 90  
XP_020024032  133 EQQRQREQQ-----RQE-ELEKQRLEQQL 155 
1_pfamImport   80 EQQQKLEQQ-----RQE-ELEKQRLEQQL 102 
XP_008565362  126 EKEQKLEQQ-----RQEqEVERHRREQQL 149 
AAQ97977      104 EKERKLELQ-----SQErELERHRREQQV 127 
XP_022531068  132 EHHRKMEKH-----RVEqELEKQQREQKL 155 
XP_021565298  130 HQRKLERHR-----QEQeLEKQHREqklq 153 
2_pfamImport   65 IHQRNMRKG-----VEDrECSRGH----- 83  
XP_021565298  129 EHQRKLERH-----RQEqELEKQHREQKL 152
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