Conserved Protein Domain Family
HDAC4_Gln

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pfam12203: HDAC4_Gln 
Glutamine rich N terminal domain of histone deacetylase 4
This domain is found in eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam00850. The domain forms an alpha helix which complexes to form a tetramer. The glutamine rich domains have many intra- and inter-helical interactions which are thought to be involved in reversible assembly and disassembly of proteins. The domain is part of histone deacetylase 4 (HDAC4) which removes acetyl groups from histones. This restores their positive charge to allow stronger DNA binding thus restricting transcriptional activity.
Statistics
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PSSM-Id: 403429
View PSSM: pfam12203
Aligned: 10 rows
Threshold Bit Score: 35.6005
Threshold Setting Gi: 1147284885
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005472509   66 SDPGLWERQLQQELLLIQKQQQIQKQLLISEFQKQHEKLTRQHQAQLQEHLKL----QQELQA---------MKQQQElA 132  Nile tilapia
CAG05956        2 VDTTMREQQLQQELVLLKQQQELQKQMLFAEFQKKHEVLTRQHEVQLQEHLKQ----QQELLA---------AKRQQE-L 67   spotted green...
XP_020024032   67 VDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ----QQEMLA---------AKRQQE-L 132  American beaver
1_pfamImport    1 VDPLFREQQLQHELLILKQQQQMQKQLLFAEFQKQHEHLTRQHEVQLQEHIKQiaspHQIFHVvymcplssfMKRQQE-L 79  
XP_008565362   59 VDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKL----QQELLA---------IKQQQElL 125  Sunda flying ...
AAQ97977       37 SEVTVWERQLQQELLLIQKQQQIQKQLLITEFQKQHENLVRQHQAQIQEHLKL----QQELHV---------MKQQQEqL 103  zebrafish
XP_022531068   65 VDSSLQDQQLQQELLSLKHKQQVQRQLLIAEFQRQHEQLSRQHEAQLQEHIKH----QQDLLA---------LQHQQElL 131  Mexican tetra
P56524         63 EPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQ----QEMLAM---------KHQQELlE 129  human
2_pfamImport    1 AEPALREQQLQQELLALKQKQQLQRQILIAEFQRQHEQLSRQHEAQLHEHVKQ----NEKL------------THEQTrC 64  
P56524         62 AEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQ----QQEMLA---------MKHQQElL 128  human
XP_005472509  133 EKERRLEQQqqqqsQQEkEQEKHRREHHI 161  Nile tilapia
CAG05956       68 EQKRKLEQQ-----RHE-EQEKHRLEQQL 90   spotted green pufferfish
XP_020024032  133 EQQRQREQQ-----RQE-ELEKQRLEQQL 155  American beaver
1_pfamImport   80 EQQQKLEQQ-----RQE-ELEKQRLEQQL 102 
XP_008565362  126 EKEQKLEQQ-----RQEqEVERHRREQQL 149  Sunda flying lemur
AAQ97977      104 EKERKLELQ-----SQErELERHRREQQV 127  zebrafish
XP_022531068  132 EHHRKMEKH-----RVEqELEKQQREQKL 155  Mexican tetra
P56524        130 HQRKLERHR-----QEQeLEKQHREqklq 153  human
2_pfamImport   65 IHQRNMRKG-----VEDrECSRGH----- 83  
P56524        129 EHQRKLERH-----RQEqELEKQHREQKL 152  human
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