2LRU,7O86,5O2C


Conserved Protein Domain Family
OSR1_C
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pfam12202: OSR1_C (This model is not part of the current CDD release)
Oxidative-stress-responsive kinase 1 C-terminal domain
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. There is a single completely conserved residue F that may be functionally important. OSR1 is involved in the signalling cascade which activates Na/K/2Cl cotransporter during osmotic stress. This domain is the C terminal domain of OSR1 which recognises a motif (Arg-Phe-Xaa-Val) on the OSR1-activating protein WNK1.
Links
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Statistics
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PSSM-Id: 520128
Aligned: 23 rows
Threshold Bit Score: 76.5328
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2LRU_A         26 IKLWLRIEDikklkgKYKDNEAIEFSFDLERDVPEDVAQEMVESGYVCEGDHKTMAKAIKDRVS 89   Norway rat
XP_015795029  352 IEFRLIVTDpkkrkdKYKENEAIQFYFEIDKDNADEVALALVATGFLMEEDVRTVALLIRNQIS 415 
2_pfamImport    1 VEFRLRVLDpkkrsnKHKENEAIQFDFDIQADNAEEVALEMAKSSLILEEDAKAVAKMLKSQIT 64  
XP_049327454  412 IGLRLWVEDqkklkgKYKDSGAIEFTFDLEKEAPDTVAQEMVDSGLFLECDVKLVSKSIRDRVA 475 
XP_040032453  458 LKLWLRMDDtkklhgKYKENNAIEFLFELYTDVPEEVCQEMVGLGFVCEADFKLVAKAIRDRVA 521 
ELK01464      123 LKLWLRMEDarr-ggRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVA 185 
XP_040048804  491 LALRIWVDEpkklkgKHKDNEAIEFSYDLENDSAEEVALEMVKSGFFHESDAKVVGKSIRDRVN 554 
KAF8381532    387 INLVLRVRN------QQRELNDIKFDFTRGTDSVEGIAHELVTAELIDCHDLVIVAANLQKLIE 444 
XP_042937382  381 INLVLRVRN------AQKELNDIKFDYTPSVDTVEGIAHELVAAELIDGHDLVVVAANLKKLVD 438 
EEC15508      182 VELRLRVLDpkkrkdKHRENEAIQFEFHVENDNPDEIAKAMALTGIIMEEDARIVSMLIRNQIA 245
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