6WCZ


Conserved Protein Domain Family
STAT2_C

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pfam12188: STAT2_C (This model is not part of the current CDD release)
Signal transducer and activator of transcription 2 C terminal
This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam02865, pfam00017, pfam01017, pfam02864. There is a conserved DLP sequence motif. STATs are involved in transcriptional regulation and are the only regulators known to be modulated by tyrosine phosphorylation. STAT2 forms a trimeric complex with STAT1 and IRF-9 (Interferon Regulatory Factor 9), on activation of the cell by interferon, which is called ISGF3 (Interferon-stimulated gene factor 3). The C terminal domain of STAT2 contains a nuclear export signal (NES) which allows export of STAT2 into the cytoplasm along with any complexed molecules.
Statistics
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PSSM-Id: 520120
Aligned: 7 rows
Threshold Bit Score: 75.6265
Created: 16-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WCZ_A       783 SQPVPEPDLPCDLRHLNTEPMEIFRNC-VKIEEIMPNGDPLLAGQNTVDEVYVSRPS 838  human
NP_001253856 783 SQPVPEPDLPCDLRHLNTEPMEIFRNC-VKIEEIMPNGDPLLAGQNTVDEAYVSRPS 838 
EHB06535     736 SQPVPDSDLPHDLQHLSTKDMEIFRNT-VNIEDIMPNGDPLLAGQNVMDEPYMSCPS 791 
Q9WVL2       854 LQQPSESDLPEDLQQISVEDLKKLSNP--STEYITTNENPMLAGESSGDETSIPYHS 908  house mouse
NP_001192618 789 LQPMPEPDLPYDLRHLNTEDMEIFRNS-MRIEEIMPNGDPVLPCQNTMDEADIFNPS 844 
1_pfamImport   1 -EPVPEPDLPHDLRHLNIEEMEIFRNSsMKLEEILPNGDPPLPAPSTMDDVYVSCPS 56  
EGW12499     737 SQLSPESDLPQDLQQLNMVDMEIFRNNiINIDDIMPHGDPLLADQNIGDEAYMSCQS 793 
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