Conserved Protein Domain Family
IR1-M

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pfam12185: IR1-M 
Nup358/RanBP2 E3 ligase domain
This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00638, pfam00641, pfam00160. There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.
Statistics
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PSSM-Id: 403422
View PSSM: pfam12185
Aligned: 14 rows
Threshold Bit Score: 76.3161
Threshold Setting Gi: 163915640
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAI57560      466 DVLIVYEVTPTPEQKALAEMLLLPLTFFCyknnpGYVSDESd-IDD-EDFETA--VKNLNGILYPED 528  tropical clawed frog
XP_008105263 2519 ECVLVWEKKPTPEEKAKAEILKLPPTFLC-----GISSDTDedNENlEDFQTE--LRKVQEAKEAQV 2578 green anole
XP_012401642 2466 ECMIVWEKKPTSEEKAKAETLQLPPTFFC-----GVCSDTDedSSHpEDFNSE--VQKVQEAKKSHD 2525 Tasmanian devil
XP_015217019 2419 EVLIVFEQQPTREQEEMARSLMLPCTFFCyknkpGYMSDDQd--DD-EDYDTA--VKKLNGKLYPDQ 2480 spotted gar
XP_005452041 2433 EVEIVYVREPTAEQAALARKLQLPITFFCyknepGYISDDQ--TDD-EDYESA--VKALNGKLYPDP 2494 Nile tilapia
XP_016154802 1825 ECAATWEKKPAPEEKDETKALQAPSTSLC-----GVSTDTE--GDSlEDVKSEakIQEMKenevass 1884 collared flycatcher
XP_014949855 2530 ECVIVWEKKPTVEEKAKADTLKLPPTFFC-----GVCSDTDedNGNaEDFQSE--LQKVQEAQKSQD 2589 sheep
XP_028913789 1031 ECVIVWEKKPTPEEKARAETLQLPPTFFC-----GVGSDTDddDDPlEDFQTE--FRKAQEAEKPQD 1090 platypus
XP_014351246 2711 ECVIVWEKKPTPEEAAKAENLKLPPTFFC-----GVSSDTEddKYNqEDFETE--VRKVKESQDNQG 2770 coelacanth
XP_016154802 1739 EVEIIYELTPTPEQRALADFLKLPSTFFCyknkpGYVSDEDd---D-EDYETA--VKKLHGRLYPSD 1799 collared flycatcher
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