3WUV


Conserved Protein Domain Family
EABR

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pfam12180: EABR (This model is not part of the current CDD release)
TSG101 and ALIX binding domain of CEP55
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. This domain is the active domain of CEP55. CEP55 is a protein involved in cytokinesis, specifically in abscission of the plasma membrane at the midbody. To perform this function, CEP55 complexes with ESCRT-I (by a Proline rich sequence in its TSG101 domain) and ALIX. This is the domain on CEP55 which binds to both TSG101 and ALIX. It also acts as a hinge between the N and C termini. This domain is called EABR.
Statistics
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PSSM-Id: 520116
Aligned: 10 rows
Threshold Bit Score: 42.4795
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3WUV_A        17 EIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFE 50  human
XP_006630145 255 KQQVAYVENLNAKWQKYDSSREEFVKGLCQKLKQ 288
Q99JG7       215 KQKVTHVEDLNAKWQRYDASRDEYVKGLHAQLKR 248 house mouse
XP_002916146 171 EIQLKDALEKNQQWLVYDQQREAYVKGLLAKIFE 204
XP_023196336 165 D-QLKDALEKNQQWLVYDQQREVFVQSVVARTME 197
XP_013131018 146 QIHLRDALEKNKQWLEYDQQREAYVRAILARMLW 179
Q502I3       164 QEQLRDALEKNQHWLVYDQQREAYVQGVLARIKD 197 zebrafish
1_pfamImport   1 KQKVLHVEDLNAKWQRYDTSRDEYVREIHAQLRE 34 
XP_692717    230 KKRVAYVESLNSKWQKYDSSREEYVRGLCQKLKE 263
XP_003972361 229 KQRVAYVQNLNSQWQKYDSSRQDYIRSLCHRPKE 262 torafugu
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