Conserved Protein Domain Family
IKKbetaNEMObind
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pfam12179: IKKbetaNEMObind (This model is not part of the current CDD release)
I-kappa-kinase-beta NEMO binding domain
This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with pfam00069. These proteins are involved in inflammatory reactions. They cause release of NF-kappa-B into the nucleus of inflammatory cells and upregulation of transcription of proinflammatory cytokines. They perform this function by phosphorylating I-kappa-B proteins which are targeted for degradation to release NF-kappa-B. This kinase (I-kappa-kinase-beta) is found in association with IKK-alpha and NEMO (NF-kappa-B essential modulator). This domain is the binding site of IKK-beta for NEMO.
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Statistics
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PSSM-Id: 520115
Aligned: 20 rows
Threshold Bit Score: 45.4066
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_056669579 706 EELVTETQSLCTQLQSMMEDAMKKQDQSFMTLDWSWL 742
XP_011601695 687 HQLLEENENYLSQLTSLLQETTRDPEYSIMEQDWSWT 723
8_pfamImport   1 HQLLEENENYLSQLTSMLQETTKETEHTVVEQDWSWT 37 
XP_003441159 686 HQLLDENQRYLSQLTSLLQDATQEMEHSIMDQDWSWT 722
XP_005811961 687 QQLLDENQRYLNHLTSLMQDATQELKQSVMDQDWSWV 723
5_pfamImport   1 AQMIKENLNYLGRVSTIIREANEERGSSMMNLDWSWL 37 
Q60680       707 AQMIEENLNCLGHLSTIIREANEDQSSSLMSLDWSWL 743 house mouse
9_pfamImport   1 AHLIEENLSYLHSFSTVIQEATHGQSSSLKSLDWSWL 37 
O15111       707 AQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWL 743 human
XP_056653705 674 TQIVEENLNYLGCLSTVIREATEEQGKNLMSLDWSWL 710 gray short-tailed opossum
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