2I2X


Conserved Protein Domain Family
MtaB

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pfam12176: MtaB (This model is not part of the current CDD release)
Methanol-cobalamin methyltransferase B subunit
This family of proteins is found in bacteria and archaea. Proteins in this family are approximately 460 amino acids in length. MtaB folds as a TIM barrel and contains a novel zinc-binding motif. Zinc(II) lies at the bottom of a funnel formed at the C-terminal beta-barrel end and ligates to two cysteinyl sulfurs (Cys-220 and Cys-269) and one carboxylate oxygen (Glu-164). The function of this protein is to catalyze the cleavage of the C O bond in methanol by an SN2 mechanism. It complexes with MtaA and MtaC to perform this function.
Statistics
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PSSM-Id: 520112
Aligned: 21 rows
Threshold Bit Score: 670.948
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2I2X_A         3 AKRYTSMAYANADEMTFGVSKYPVKAGLDLEIGAGYTIPEINYA--PRPEAGASKEKLIKEY-ERITTDVMERMVQVGFP 79  Methanosarcina ...
2_pfamImport   1 --KYTGMAYKSADDMVMGTALHPVSEGFGLKIGAGQVVPEINYA--PRPGTEKDPAKLRKEYvDYITTDILNRAVTAGFP 76 
WP_020448491   3 LKRYTRMEYTSPDDMVFGEAKYPVSYGLGQVIGAGVVVPEIKFA--PRVGSEKTPESLRREFvDYITRDVLDRAITLGFP 80  Candidatus Meth...
Q2NHN2         3 RKYFTKMENASADEMVFGQTKHPVKMGLDQVMGGGEVVPNIKVA--PAEGSEESIDGLEATS-KNIAFAACDRAAAIGLP 79  Methanosphaera ...
Q2NHN0         3 AKRFTKMENKSADDLVFGKAANPVEYGFGVKLGVGEVVPNIKVA--PAEGSETSVEGMVATC-KNIAFSACDRAAAVGLP 79  Methanosphaera ...
WP_014254111   1 -mKFNQLAYDNVNDFVYGVSKKPVVCKNGLVIGGGTIYPELNFTlpTMIITKDSMPDVIKEY-KAIIEDALKRAKELYVP 78  Acetivibrio cla...
3_pfamImport   1 --KFNKLAYNSVDDFVYGSCKKPVTTKSGLVIGGGDVYPELNFTlpSMIVNEDSIKDAYQIY-KDMTNGILNRARELYAP 77 
1_pfamImport   1 --KFDKMAYASADEMIFGTAKNPVKYGRDFTVGGGYVFPELVPH--PRPGTETTKKTLVKEY-EKMVTDVLGRCVAIGIP 75 
WP_014809881   1 mnLSSEMAYKSADEMIFGTAKKPVTTKRGIVLGGGHVVPEVVPH--PRPGSEKTMKTLLREY-ERANGDALERCVIVGHP 77  Desulfomonile t...
Q0W3A7         3 LKLSNSMAYQSPDLMMFGSALKPVRVRCGMAIGGGAVIPEIVPH--PRLGSEQNLKTLLREF-ERANGDALEQCILLGFP 79  uncultured meth...
2I2X_A        80 AIILETEHVQQMSNNPS-WGAEVAHAQKTIMEKYHDEYGIKCALRHTIGDIRENREFLQLRGDKY----SVFLEAFEQCA 154 Methanosarcina ...
2_pfamImport  77 AVHLETEWVSQM--NQEkLCAPVVAGQKEVCEKFHEEYGIACGVRQTIPDQREHDMGLRPGMDSVhaypEKFFECCDYAC 154
WP_020448491  81 AVQLENEHISHMTNDVEhYAKPIVSGQKELMQKYHDQYDIALSIRHTIADPRMAELGLREEMDQKhsypQKIIDSCHVAA 160 Candidatus Meth...
Q2NHN2        80 AIQIEMEHVQQQSISKE-ASARCTAVTFEELEKLHDKFGTKVSMMSTVADMREEENG--LRGSEFd---VAMDESFEACA 153 Methanosphaera ...
Q2NHN0        80 TVQIEQEHVAQQTKSRE-ISAKTTAVQIEQLEELHDKYGTKTSLMSTIADIREEDMG-GLRGSDFd---VMMDESFEACA 154 Methanosphaera ...
WP_014254111  79 GLVVEIELLPPTTYNPE-WGVEITKAVREIMYDYEAKHGLKSVMRITPVDIREDKKSPHMWHGSHw---DAIMETFEGCA 154 Acetivibrio cla...
3_pfamImport  78 GVVIEYETLPEFTENPK-WGIEVSKIIVDTMKEYEAKYGLKSAYRATPNDLREMNRPPIMRSGKYw---EAMIESFAGCS 153
1_pfamImport  76 GIQIELEHVYQMTKNPD-WGGEIAAATKHLQEEYHRKYGLKSAIRATIADYRKPDEEDIRNCVAL----ENQLKTFETSA 150
WP_014809881  78 QLQIENEHIFQMTHNPK-WGGEIAAQTARQMDEYLQKYGLKAAYRATPADLRKPDMVNMRDSDYT----REVLETFEECA 152 Desulfomonile t...
Q0W3A7        80 GIIIENEHVSQMTQNPD-WGKEIARQTAGQIDDYYDKYGLSAGYRATIADLRKPEVAHLRRSDRA----SLILEAFEACA 154 uncultured meth...
2I2X_A       155 ENGADLLSVESMGGKEVFDYAVLRNDIPGLLYSIGCLGSIDMELIWTDISKIAKKTGTISAGDTDCAQANTAMFIGGGLL 234 Methanosarcina ...
2_pfamImport 155 ENGADNLSVESVGGKEFADYAVTHGDIVAFLFGVGYLGSIDMDYIWNQMVDIAKRNRTVPGGDTDCSGANVSMFMAGGMM 234
WP_020448491 161 ENGADLLSIESIGGKELADYSLLRQDIRGWLFGIGYLGSIDMEWLWPQIVHIAKKNRIRAGGDTCCAGANTAMFLAGGYM 240 Candidatus Meth...
Q2NHN2       154 QNGASMLCIETVGGKVVSDYGISRGDARAILYGIGVLGSIDMEYMWTKIVDIAKRNNVVPGGDTDCAQANTAMFLAGGLT 233 Methanosphaera ...
Q2NHN0       155 ENGTSILCVETIGGKVVSDYGISRGDIRAILYGIGLLGSIDMEYMWTKISDIASHHDCVPGGDTDCAQANTAMFLGGGLT 234 Methanosphaera ...
WP_014254111 155 KAGADLLSIESIGGKDMHDEAMMFCEIDKSLFSLGVLGSMDMSRLWKEIKAIADRTGTIAAGDSACGFANTVMVLADRGF 234 Acetivibrio cla...
3_pfamImport 154 QAGADFISVESTGGKELNDEALVNADIKQVIFALGVCGCRDMKFLWKNISDICKANGSLPAGDSACGFGNTAMVLAERGM 233
1_pfamImport 151 AGGADNLSIESVGGKEISDYTIVRQDIRGTLFGIGVLGSRDMEFMWKKIVEIADKYGVTPGGDTDCAQANVAMFMAGGYQ 230
WP_014809881 153 KY-ADIVSIESMGGKEVFDHAIIRNDIAGLLFGQAVLGGRDMEWMWTQIVAIAKKHNCIPGGDTNCSEANTAMFMAGGYL 231 Desulfomonile t...
Q0W3A7       155 EH-ADIISIESVGGKEISDHAIIRNDVTGMLFAQAVLGGRDMEWLWPQIVGIAKKRGCIAGGDTDCAQANVAMYLAGGFA 233 uncultured meth...
2I2X_A       235 NKNLAHTIAVIARAISAPRSLVAYEAGAVGPGKDCGYENIIVKAITGMPMTMEGKTSTCAHSDVMGNLVMQCCDCWSNES 314 Methanosarcina ...
2_pfamImport 235 DNDVQKTFSAITRAISAARTLVAWEAGAQGPDKDCGYEGIICKAIAGKPTTQEGKNCQCAHCDLMGNLSAQVCDCWSNES 314
WP_020448491 241 DKEIPRTFSAVTRAIAATRTLVAWEAGATGPDKDCGYEGPIVKAISGKPTSQEGKNSHCAHMDLMGNLIAQVCDLWSNES 320 Candidatus Meth...
Q2NHN2       234 SKNVSHTIAAVARAIAGARSLVAVECGAQGPTKDCGYENPIVKAIASVPICAEGKNATCAHSDLMGNLTAAVCDVWSNES 313 Methanosphaera ...
Q2NHN0       235 SKNVSHTLAAVARAISGARSLVAVECGAVGPLKDCGYENPIVKAIGGVPICAEGKNATCAHSDLMGNLACAVVDCWSNES 314 Methanosphaera ...
WP_014254111 235 ---VPKIFSAVVRVISSVRSLVAIEEGAFGPHKDCGYEGVYIKAITGTPISMEGKSSACAHLSPVGNIAACVADLWSNES 311 Acetivibrio cla...
3_pfamImport 234 ---IPKVFAAVVRVATVARALAAFEEGAVGPSKDCAYEGVYLKAITGSPISCEGKSAACAHLSPIGNIAAAVTDLWSNES 310
1_pfamImport 231 DRSVPHTFAALTRAISAARSLVAYEQGAKGPSKDCGYEDVIIKAITGVPIAMEGKASACAHSDLVGNLIAACCDLWSNEA 310
WP_014809881 232 SKDVPHTLAALSRAICASRTLVAYECGATGPTKDCAYEDPIIKSVTGVPISCEGKTSACAHADLCGNVIAAVTDVWSNEA 311 Desulfomonile t...
Q0W3A7       234 SKDVPHSLAALCRAMAAGRSLVAYECGATGPGKDCGYENPIIKAITGLPMSAEGKTSACAHLSLCGNVTAAVCDLWANEA 313 uncultured meth...
2I2X_A       315 VEYHGEFGGTTVQCWSETLAYDCALMNTALETKNDK--VLRDLMMLSDRYRDPQAYMLAYDNAYRVGQSIVKDGDNIYLR 392 Methanosarcina ...
2_pfamImport 315 VEYHPEFGGTSVQCWLGSLGYEVALMNTAIQTHQEK--TLRDLYCITDMTRSPESYILAYNNAYEIGKVIAENGDSYYLR 392
WP_020448491 321 VEYHPEFGGSSVQCWLGNIGYEAALMNTAKQLKQDR--LLRDLYMATDRYRSPEAFILAYDNAYKIGQAIVEYGSDIYMR 398 Candidatus Meth...
Q2NHN2       314 VYNREEMGGPTPGVWLQSLGYECALMNTATQIGTNK--QLRDTYVLADKYRDPQGVILAYDNAYKIGEAITAEGEDIYLR 391 Methanosphaera ...
Q2NHN0       315 VYNREEMGGPTPGVWLQSLGYECALMNTATKINKEK--DLRDIYTLADKYRDPQALILAYDNAYRIGEAIVAEGEDIYLR 392 Methanosphaera ...
WP_014254111 312 VQNIKLLGGMAPTVSLEQLAYDCRLMNTAAASGKESalLLRDWLCDSDSKFDPQAYVLRPDVVIEISKEIIKKDTP-FER 390 Acetivibrio cla...
3_pfamImport 311 VQQVKLLAEMAPVVSIEQLVYDTRLMNTATKKGFRK--EFRDLLAESDAPLDPQAYVLKPQVVYDIASELVKAENS-FQM 387
1_pfamImport 311 VEYHDMFGGTTVAVFTEILGYDVALMNTAIEMGQAK--ILRDMMVESDKYRDTHGFILCPQNAYEIGKAIVENNTSYYAR 388
WP_014809881 312 VEYHDMFGGTTTAVFAEILGYDVAAMNAAIDLGYQK--EFQACLVNSDKYRGPHAFMLSPDNAWQIGKALVDNNASLYSR 389 Desulfomonile t...
Q0W3A7       314 VEYHEMFGGTTPAVFTEMLGYDAAMMNSSIALGFHK--ELQACMINSDRYRSPHGYILCPDIAWEIGKAIVENNDSMYSR 391 uncultured meth...
2I2X_A       393 AKNAAIECCNIIEEGAa-GKLELSRFETKALADAKAALEALPDDMDKFMDDCLTKYKSeVKVFKPEN 458 Methanosarcina barkeri
2_pfamImport 393 SKAAAEKAIEIIESGYnsKTLQLTKKQYDVLEDCKKKIVALPTEEDAFVEQCVKEFTGvVPNFNMKN 459
WP_020448491 399 AKAAAMTAAKLIEDESkfGRLKLSKHEQDMLRKIITDLSALPDEEGKFVDQCLSVYKD-VPKFNPKN 464 Candidatus Methanomassiliico...
Q2NHN2       392 SRAAAIRAMELINEAVdeKRILLTRFERDTLDSTMKTYEQLPDDKDKFIKTCIKRYGRkVKEHDPSQ 458 Methanosphaera stadtmanae DS...
Q2NHN0       393 SRAAALEGISIINEAVdeKRMFLTRFERDSLDSAQKTIEQLPEDKDKFAKACIKRYGRkVKEHDPSQ 459 Methanosphaera stadtmanae DS...
WP_014254111 391 SKVAALKAIDVLEKAVadNKVQVSERELQYLPSMKRQIEAIPEDVEEFISEMIERDE--SGKLDPQK 455 Acetivibrio clariflavus
3_pfamImport 388 TKMGAQLALDKITEAVnsGEVYVEEREKKWLDIIGNQIDDIADDELEFYDDMQDELD--MDKFIPSE 452
1_pfamImport 389 ARAAAIKAGELMLKd---SKLQMSAFEKESLESAMRTLESLPEKEEDFISECADIYKKlIPGFSLAN 452
WP_014809881 390 AKAAAMKCGELMLGd---PMLKLTAYEKEMLQGYMKDMQALPDKEGDFIDMCLKKYSK-VKGFVPAA 452 Desulfomonile tiedjei
Q0W3A7       392 AKAAALKCGQLMLSd---ARLRFTAYERDSLLGYMKELEALPDREGDFIDMCLKKYER-VKAFKPAS 454 uncultured methanogenic arch...
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